Timeline
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Ariel Mechaly
Research Engineer
05 Apr 2024
publication
Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.
Read more18 Mar 2024
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Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms
Read more05 Feb 2024
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Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2.
Read more06 Jan 2024
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Ton motor conformational switch and peptidoglycan role in bacterial nutrient uptake.
Read more10 Aug 2023
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High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase.
Read more20 Jun 2023
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Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs.
Read more02 Feb 2023
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Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.
Read more01 Feb 2023
news
Bacterial pathogenicity: improving understanding of an essential process – molecule secretion
Read more11 Jan 2023
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The c-di-AMP-binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae.
Read more01 Jan 2023
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Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity.
Read more09 Aug 2022
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Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.
Read more12 Feb 2022
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Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.
Read more01 Jan 2022
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Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins.
Read more22 Nov 2021
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Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy.
Read more01 May 2021
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A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.
Read more13 Jan 2021
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Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.
Read more06 Nov 2020
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Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.
Read more06 Jul 2020
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Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.
Read more11 Mar 2020
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An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete.
Read more05 Dec 2019
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High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur
Read more31 Jul 2019
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Directly Sequenced Genomes of Contemporary Strains of Syphilis Reveal Recombination-Driven Diversity in Genes Encoding Predicted Surface-Exposed Antigens
Read more17 Oct 2018
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Evidence of Alternative Splicing as a Regulatory Mechanism for Kissr2 in Pejerrey Fish
Read more04 Aug 2018
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Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance
Read more15 Jul 2018
23 Feb 2018
publication
Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic
Read more20 Aug 2017
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Snapshots of the Signaling Complex DesK:DesR in Different Functional States Using Rational Mutagenesis and X-ray Crystallography.
Read more25 May 2017
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Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase
Read more21 Feb 2017
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Crystallization of FcpA from Leptospira, a novel flagellar protein that is essential for pathogenesis
Read more12 Dec 2016
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Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action
Read more18 Feb 2016
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What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira
Read more10 Dec 2015
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Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis
Read more11 May 2015
17 Feb 2015
18 Nov 2014
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Allosteric activation of bacterial response regulators: the role of the cognate histidine kinase beyond phosphorylation
Read more13 May 2014
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Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins)
Read more28 Jan 2014
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Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation
Read more21 Jun 2012
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Pores of the toxin FraC assemble into 2D hexagonal clusters in both crystal structures and model membranes
Read more03 May 2012
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Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.
Read more09 Feb 2011
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Structural insights into the oligomerization and architecture of eukaryotic membrane pore-forming toxins
Read more21 Mar 2009
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Crystallization and preliminary crystallographic analysis of fragaceatoxin C, a pore-forming toxin from the sea anemone Actinia fragacea
Read more11 Mar 2008
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A plate holder for non-destructive testing of mesophase crystallization assays
Read more08 Jul 2006
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