Ligne de temps
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Ariel Mechaly
Ingénieur(e) de Recherche
05 avr. 2024
publication
Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.
Lire plus18 mars 2024
publication
Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms
Lire plus05 févr. 2024
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Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2.
Lire plus06 janv. 2024
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Ton motor conformational switch and peptidoglycan role in bacterial nutrient uptake.
Lire plus10 août 2023
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High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase.
Lire plus20 juin 2023
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Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs.
Lire plus02 févr. 2023
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Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.
Lire plus01 févr. 2023
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Bacterial pathogenicity: improving understanding of an essential process – molecule secretion
Lire plus11 janv. 2023
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The c-di-AMP-binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae.
Lire plus01 janv. 2023
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Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity.
Lire plus09 août 2022
publication
Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.
Lire plus12 févr. 2022
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Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.
Lire plus01 janv. 2022
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Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins.
Lire plus22 nov. 2021
publication
Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy.
Lire plus01 mai 2021
publication
A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.
Lire plus13 janv. 2021
publication
Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.
Lire plus06 nov. 2020
publication
Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.
Lire plus06 juil. 2020
publication
Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.
Lire plus11 mars 2020
publication
An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete.
Lire plus05 déc. 2019
publication
High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur
Lire plus31 juil. 2019
publication
Directly Sequenced Genomes of Contemporary Strains of Syphilis Reveal Recombination-Driven Diversity in Genes Encoding Predicted Surface-Exposed Antigens
Lire plus17 oct. 2018
publication
Evidence of Alternative Splicing as a Regulatory Mechanism for Kissr2 in Pejerrey Fish
Lire plus04 août 2018
publication
Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance
Lire plus15 juil. 2018
23 févr. 2018
publication
Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic
Lire plus20 août 2017
publication
Snapshots of the Signaling Complex DesK:DesR in Different Functional States Using Rational Mutagenesis and X-ray Crystallography.
Lire plus25 mai 2017
publication
Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase
Lire plus21 févr. 2017
publication
Crystallization of FcpA from Leptospira, a novel flagellar protein that is essential for pathogenesis
Lire plus12 déc. 2016
publication
Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action
Lire plus18 févr. 2016
publication
What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira
Lire plus10 déc. 2015
publication
Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis
Lire plus11 mai 2015
17 févr. 2015
18 nov. 2014
publication
Allosteric activation of bacterial response regulators: the role of the cognate histidine kinase beyond phosphorylation
Lire plus13 mai 2014
publication
Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins)
Lire plus28 janv. 2014
publication
Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation
Lire plus21 juin 2012
publication
Pores of the toxin FraC assemble into 2D hexagonal clusters in both crystal structures and model membranes
Lire plus03 mai 2012
publication
Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.
Lire plus09 févr. 2011
publication
Structural insights into the oligomerization and architecture of eukaryotic membrane pore-forming toxins
Lire plus21 mars 2009
publication
Crystallization and preliminary crystallographic analysis of fragaceatoxin C, a pore-forming toxin from the sea anemone Actinia fragacea
Lire plus11 mars 2008
publication
A plate holder for non-destructive testing of mesophase crystallization assays
Lire plus08 juil. 2006
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