Ligne de temps
Ariel Mechaly
Ingénieur(e) de Recherche
05 avr. 2024
publication
Insights from structure-activity relationships and the binding mode of peptidic α-ketoamide inhibitors of the malaria drug target subtilisin-like SUB1.
Lire plus18 mars 2024
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Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms
Lire plus05 févr. 2024
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Structural and enzymatic evidence for the methylation of the ACK1 tyrosine kinase by the histone lysine methyltransferase SETD2.
Lire plus06 janv. 2024
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Ton motor conformational switch and peptidoglycan role in bacterial nutrient uptake.
Lire plus10 août 2023
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High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase.
Lire plus20 juin 2023
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Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs.
Lire plus02 févr. 2023
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Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.
Lire plus01 févr. 2023
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Bacterial pathogenicity: improving understanding of an essential process – molecule secretion
Lire plus11 janv. 2023
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The c-di-AMP-binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae.
Lire plus01 janv. 2023
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Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity.
Lire plus09 août 2022
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Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.
Lire plus12 févr. 2022
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Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.
Lire plus01 janv. 2022
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Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins.
Lire plus22 nov. 2021
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Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy.
Lire plus01 mai 2021
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A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.
Lire plus13 janv. 2021
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Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein.
Lire plus06 nov. 2020
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Deciphering the Unexpected Binding Capacity of the Third PDZ Domain of Whirlin to Various Cochlear Hair Cell Partners.
Lire plus06 juil. 2020
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Evolution of abiotic cubane chemistries in a nucleic acid aptamer allows selective recognition of a malaria biomarker.
Lire plus11 mars 2020
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An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete.
Lire plus05 déc. 2019
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High-Throughput Crystallization Pipeline at the Crystallography Core Facility of the Institut Pasteur
Lire plus31 juil. 2019
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Directly Sequenced Genomes of Contemporary Strains of Syphilis Reveal Recombination-Driven Diversity in Genes Encoding Predicted Surface-Exposed Antigens
Lire plus17 oct. 2018
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Evidence of Alternative Splicing as a Regulatory Mechanism for Kissr2 in Pejerrey Fish
Lire plus04 août 2018
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Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance
Lire plus15 juil. 2018
23 févr. 2018
publication
Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic
Lire plus20 août 2017
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Snapshots of the Signaling Complex DesK:DesR in Different Functional States Using Rational Mutagenesis and X-ray Crystallography.
Lire plus25 mai 2017
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Structural Coupling between Autokinase and Phosphotransferase Reactions in a Bacterial Histidine Kinase
Lire plus21 févr. 2017
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Crystallization of FcpA from Leptospira, a novel flagellar protein that is essential for pathogenesis
Lire plus12 déc. 2016
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Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action
Lire plus18 févr. 2016
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What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira
Lire plus10 déc. 2015
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Structural Basis of Pullulanase Membrane Binding and Secretion Revealed by X-Ray Crystallography, Molecular Dynamics and Biochemical Analysis
Lire plus11 mai 2015
17 févr. 2015
18 nov. 2014
publication
Allosteric activation of bacterial response regulators: the role of the cognate histidine kinase beyond phosphorylation
Lire plus13 mai 2014
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Potent and specific inhibition of glycosidases by small artificial binding proteins (affitins)
Lire plus28 janv. 2014
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Segmental helical motions and dynamical asymmetry modulate histidine kinase autophosphorylation
Lire plus21 juin 2012
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Pores of the toxin FraC assemble into 2D hexagonal clusters in both crystal structures and model membranes
Lire plus03 mai 2012
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Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.
Lire plus09 févr. 2011
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Structural insights into the oligomerization and architecture of eukaryotic membrane pore-forming toxins
Lire plus21 mars 2009
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Crystallization and preliminary crystallographic analysis of fragaceatoxin C, a pore-forming toxin from the sea anemone Actinia fragacea
Lire plus11 mars 2008
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A plate holder for non-destructive testing of mesophase crystallization assays
Lire plus08 juil. 2006
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