Timeline

Zacarias Garcia

Research Engineer

01 Apr 2024

publication

Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes.

25 Mar 2024

news

New publication – Anti-PD-1 therapy triggers Tfh cell–dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes

05 Jun 2023

news

New publication – Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity

29 May 2023

publication

Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity.

17 Feb 2023

publication

Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics.

29 Aug 2022

news

New publication – Inflammation triggers ILC3 patrolling of the intestinal barrier

23 Aug 2022

publication

Inflammation triggers ILC3 patrolling of the intestinal barrier.

19 Jul 2022

publication

Spatiotemporal dynamics of calcium signals during neutrophil cluster formation.

14 Jun 2021

publication

Quorum sensing governs collective dendritic cell activation in vivo.

15 Apr 2021

publication

Functional heterogeneity of cytotoxic T cells and tumor resistance to cytotoxic hits limit anti-tumor activity in vivo.

26 Mar 2021

publication

A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity.

19 Feb 2021

news

Improving immunotherapies for blood cancers: real-time exploration in the tumor

01 Feb 2021

publication

Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis.

09 Mar 2020

publication

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment

01 Mar 2020

publication

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment.

23 Nov 2018

publication

The immune system profoundly restricts intratumor genetic heterogeneity

01 Aug 2018

publication

A human immune system mouse model with robust lymph node development.

27 Mar 2018

publication

Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division

04 Oct 2016

publication

Intravital imaging reveals improved Kupffer cell-mediated phagocytosis as a mode of action of glycoengineered anti-CD20 antibodies.

12 Jan 2016

publication

The PD-1 Axis Enforces an Anatomical Segregation of CTL Activity that Creates Tumor Niches after Allogeneic Hematopoietic Stem Cell Transplantation

21 Dec 2015

publication

In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity

14 Sep 2015

publication

Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest

15 Jun 2015

project

Immune responses against tumors

11 May 2015

team

Dynamics of Immune Responses

01 Nov 2013

publication

The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imaging

01 Feb 2013

publication

Synergy of the antibiotic colistin with echinocandin antifungals in Candida species

15 Nov 2012

publication

Dissecting T cell contraction in vivo using a genetically encoded reporter of apoptosis

12 Oct 2012

publication

Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles

13 Aug 2012

publication

Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis

10 Jul 2012

publication

The CD4⁺ T-cell help signal is transmitted from APC to CD8⁺ T-cells via CD27-CD70 interactions

25 Jul 2011

publication

Immune adjuvant efficacy of CpG oligonucleotide in cancer treatment is founded specifically upon TLR9 function in plasmacytoid dendritic cells

14 Jan 2011

publication

Selective expansion of merocytic dendritic cells and CD8DCs confers anti-tumour effect of Fms-like tyrosine kinase 3-ligand treatment in vivo

24 Sep 2010

publication

Visualizing the functional diversification of CD8+ T cell responses in lymph nodes

18 Aug 2010

publication

Prolonged antigen storage endows merocytic dendritic cells with enhanced capacity to prime anti-tumor responses in tumor-bearing mice

01 Jun 2009

publication

Dendritic cells use endocytic pathway for cross-priming class Ib MHC-restricted CD8alphaalpha+TCRalphabeta+ T cells with regulatory properties

01 Apr 2008

publication

Dendritic cell programming by cytomegalovirus stunts naive T cell responses via the PD-L1/PD-1 pathway

15 Jul 2007

publication

Chronic lymphocytic choriomeningitis virus infection actively down-regulates CD4+ T cell responses directed against a broad range of epitopes

02 Mar 2007

publication

Competition for antigen determines the stability of T cell-dendritic cell interactions during clonal expansion

01 Aug 2006

publication

Cutting edge: cognate CD4 help promotes recruitment of antigen-specific CD8 T cells around dendritic cells

11 Apr 2006

publication

Relationship between DNA methylation and histone acetylation levels, cell redox and cell differentiation states in sugarbeet lines

07 Nov 2005

publication

CD4 T cells integrate signals delivered during successive DC encounters in vivo

14 Feb 2005

publication

Lineage relationships, homeostasis, and recall capacities of central- and effector-memory CD8 T cells in vivo

01 Mar 2003

publication

Role of T cell help and endoplasmic reticulum targeting in protective CTL response against influenza virus

13 Feb 2001

publication

Human T cell leukemia virus Type I (HTLV-I) infection induces greater expansions of CD8 T lymphocytes in persons with HTLV-I-associated myelopathy/tropical spastic paraparesis than in asymptomatic carriers

01 Oct 1999

publication

H-2 class I knockout, HLA-A2.1-transgenic mice: a versatile animal model for preclinical evaluation of antitumor immunotherapeutic strategies

01 Jul 1999

publication

Molecular characterization of cDNAs encoding squirrel monkey (Saïmiri sciureus) CD8 alpha and beta chains

15 May 1998

publication

Cytotoxic T cell response against the chimeric p210 BCR-ABL protein in patients with chronic myelogenous leukemia

01 Jul 1995

publication

Restriction of self-antigen presentation to cytolytic T lymphocytes by mouse peptide pumps

01 May 1993

publication

A little guide for advanced search:

Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes.

New publication – Anti-PD-1 therapy triggers Tfh cell–dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes

New publication – Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity

Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity.

Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics.

New publication – Inflammation triggers ILC3 patrolling of the intestinal barrier

Inflammation triggers ILC3 patrolling of the intestinal barrier.

Spatiotemporal dynamics of calcium signals during neutrophil cluster formation.

Quorum sensing governs collective dendritic cell activation in vivo.

Functional heterogeneity of cytotoxic T cells and tumor resistance to cytotoxic hits limit anti-tumor activity in vivo.

A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity.

Improving immunotherapies for blood cancers: real-time exploration in the tumor

Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis.

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment.

The immune system profoundly restricts intratumor genetic heterogeneity

A human immune system mouse model with robust lymph node development.

Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division

Intravital imaging reveals improved Kupffer cell-mediated phagocytosis as a mode of action of glycoengineered anti-CD20 antibodies.

The PD-1 Axis Enforces an Anatomical Segregation of CTL Activity that Creates Tumor Niches after Allogeneic Hematopoietic Stem Cell Transplantation

In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity

Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest

Immune responses against tumors

Dynamics of Immune Responses

The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imaging

Synergy of the antibiotic colistin with echinocandin antifungals in Candida species

Dissecting T cell contraction in vivo using a genetically encoded reporter of apoptosis

Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles

Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis

The CD4⁺ T-cell help signal is transmitted from APC to CD8⁺ T-cells via CD27-CD70 interactions

Immune adjuvant efficacy of CpG oligonucleotide in cancer treatment is founded specifically upon TLR9 function in plasmacytoid dendritic cells

Selective expansion of merocytic dendritic cells and CD8DCs confers anti-tumour effect of Fms-like tyrosine kinase 3-ligand treatment in vivo

Visualizing the functional diversification of CD8+ T cell responses in lymph nodes

Prolonged antigen storage endows merocytic dendritic cells with enhanced capacity to prime anti-tumor responses in tumor-bearing mice

Dendritic cells use endocytic pathway for cross-priming class Ib MHC-restricted CD8alphaalpha+TCRalphabeta+ T cells with regulatory properties

Dendritic cell programming by cytomegalovirus stunts naive T cell responses via the PD-L1/PD-1 pathway

Chronic lymphocytic choriomeningitis virus infection actively down-regulates CD4+ T cell responses directed against a broad range of epitopes

Competition for antigen determines the stability of T cell-dendritic cell interactions during clonal expansion

Cutting edge: cognate CD4 help promotes recruitment of antigen-specific CD8 T cells around dendritic cells

Relationship between DNA methylation and histone acetylation levels, cell redox and cell differentiation states in sugarbeet lines

CD4 T cells integrate signals delivered during successive DC encounters in vivo

Lineage relationships, homeostasis, and recall capacities of central- and effector-memory CD8 T cells in vivo

Role of T cell help and endoplasmic reticulum targeting in protective CTL response against influenza virus

Human T cell leukemia virus Type I (HTLV-I) infection induces greater expansions of CD8 T lymphocytes in persons with HTLV-I-associated myelopathy/tropical spastic paraparesis than in asymptomatic carriers

H-2 class I knockout, HLA-A2.1-transgenic mice: a versatile animal model for preclinical evaluation of antitumor immunotherapeutic strategies

Molecular characterization of cDNAs encoding squirrel monkey (Saïmiri sciureus) CD8 alpha and beta chains

Cytotoxic T cell response against the chimeric p210 BCR-ABL protein in patients with chronic myelogenous leukemia

Restriction of self-antigen presentation to cytolytic T lymphocytes by mouse peptide pumps

Abrogation of H-2-restricted CTL responses and efficient recognition of HLA-A3 molecules in DBA/2 HLA/A24 responder mice