Ligne de temps

Zacarias Garcia

Ingénieur(e) de Recherche

01 avr. 2024

publication

Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes.

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25 mars 2024

news

New publication – Anti-PD-1 therapy triggers Tfh cell–dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes

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05 juin 2023

news

New publication – Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity

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29 mai 2023

publication

Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity.

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17 févr. 2023

publication

Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics.

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29 août 2022

news

New publication – Inflammation triggers ILC3 patrolling of the intestinal barrier

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23 août 2022

publication

Inflammation triggers ILC3 patrolling of the intestinal barrier.

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19 juil. 2022

publication

Spatiotemporal dynamics of calcium signals during neutrophil cluster formation.

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14 juin 2021

publication

Quorum sensing governs collective dendritic cell activation in vivo.

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15 avr. 2021

publication

Functional heterogeneity of cytotoxic T cells and tumor resistance to cytotoxic hits limit anti-tumor activity in vivo.

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26 mars 2021

publication

A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity.

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19 févr. 2021

news

Improving immunotherapies for blood cancers: real-time exploration in the tumor

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01 févr. 2021

publication

Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis.

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09 mars 2020

publication

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment

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01 mars 2020

publication

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment.

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23 nov. 2018

publication

The immune system profoundly restricts intratumor genetic heterogeneity

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01 août 2018

publication

A human immune system mouse model with robust lymph node development.

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27 mars 2018

publication

Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division

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04 oct. 2016

publication

Intravital imaging reveals improved Kupffer cell-mediated phagocytosis as a mode of action of glycoengineered anti-CD20 antibodies.

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12 janv. 2016

publication

The PD-1 Axis Enforces an Anatomical Segregation of CTL Activity that Creates Tumor Niches after Allogeneic Hematopoietic Stem Cell Transplantation

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21 déc. 2015

publication

In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity

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14 sept. 2015

publication

Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest

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15 juin 2015

project

Immune responses against tumors

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11 mai 2015

team

Dynamiques des Réponses Immunes

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01 nov. 2013

publication

The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imaging

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01 févr. 2013

publication

Synergy of the antibiotic colistin with echinocandin antifungals in Candida species

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15 nov. 2012

publication

Dissecting T cell contraction in vivo using a genetically encoded reporter of apoptosis

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12 oct. 2012

publication

Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles

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13 août 2012

publication

Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis

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10 juil. 2012

publication

The CD4⁺ T-cell help signal is transmitted from APC to CD8⁺ T-cells via CD27-CD70 interactions

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25 juil. 2011

publication

Immune adjuvant efficacy of CpG oligonucleotide in cancer treatment is founded specifically upon TLR9 function in plasmacytoid dendritic cells

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14 janv. 2011

publication

Selective expansion of merocytic dendritic cells and CD8DCs confers anti-tumour effect of Fms-like tyrosine kinase 3-ligand treatment in vivo

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24 sept. 2010

publication

Visualizing the functional diversification of CD8+ T cell responses in lymph nodes

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18 août 2010

publication

Prolonged antigen storage endows merocytic dendritic cells with enhanced capacity to prime anti-tumor responses in tumor-bearing mice

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01 juin 2009

publication

Dendritic cells use endocytic pathway for cross-priming class Ib MHC-restricted CD8alphaalpha+TCRalphabeta+ T cells with regulatory properties

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01 avr. 2008

publication

Dendritic cell programming by cytomegalovirus stunts naive T cell responses via the PD-L1/PD-1 pathway

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15 juil. 2007

publication

Chronic lymphocytic choriomeningitis virus infection actively down-regulates CD4+ T cell responses directed against a broad range of epitopes

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02 mars 2007

publication

Competition for antigen determines the stability of T cell-dendritic cell interactions during clonal expansion

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01 août 2006

publication

Cutting edge: cognate CD4 help promotes recruitment of antigen-specific CD8 T cells around dendritic cells

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11 avr. 2006

publication

Relationship between DNA methylation and histone acetylation levels, cell redox and cell differentiation states in sugarbeet lines

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07 nov. 2005

publication

CD4 T cells integrate signals delivered during successive DC encounters in vivo

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14 févr. 2005

publication

Lineage relationships, homeostasis, and recall capacities of central- and effector-memory CD8 T cells in vivo

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01 mars 2003

publication

Role of T cell help and endoplasmic reticulum targeting in protective CTL response against influenza virus

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13 févr. 2001

publication

Human T cell leukemia virus Type I (HTLV-I) infection induces greater expansions of CD8 T lymphocytes in persons with HTLV-I-associated myelopathy/tropical spastic paraparesis than in asymptomatic carriers

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01 oct. 1999

publication

H-2 class I knockout, HLA-A2.1-transgenic mice: a versatile animal model for preclinical evaluation of antitumor immunotherapeutic strategies

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01 juil. 1999

publication

Molecular characterization of cDNAs encoding squirrel monkey (Saïmiri sciureus) CD8 alpha and beta chains

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15 mai 1998

publication

Cytotoxic T cell response against the chimeric p210 BCR-ABL protein in patients with chronic myelogenous leukemia

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01 juil. 1995

publication

Restriction of self-antigen presentation to cytolytic T lymphocytes by mouse peptide pumps

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01 mai 1993

publication

Abrogation of H-2-restricted CTL responses and efficient recognition of HLA-A3 molecules in DBA/2 HLA/A24 responder mice

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Un petit guide pour l'utilisation de la recherche avancée :

Anti-PD-1 therapy triggers Tfh cell-dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes.

New publication – Anti-PD-1 therapy triggers Tfh cell–dependent IL-4 release to boost CD8 T cell responses in tumor-draining lymph nodes

New publication – Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity

Tumor-intrinsic sensitivity to the pro-apoptotic effects of IFN-γ is a major determinant of CD4+ CAR T-cell antitumor activity.

Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics.

New publication – Inflammation triggers ILC3 patrolling of the intestinal barrier

Inflammation triggers ILC3 patrolling of the intestinal barrier.

Spatiotemporal dynamics of calcium signals during neutrophil cluster formation.

Quorum sensing governs collective dendritic cell activation in vivo.

Functional heterogeneity of cytotoxic T cells and tumor resistance to cytotoxic hits limit anti-tumor activity in vivo.

A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity.

Improving immunotherapies for blood cancers: real-time exploration in the tumor

Imaging the mechanisms of anti-CD20 therapy in vivo uncovers spatiotemporal bottlenecks in antibody-dependent phagocytosis.

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment

Bystander IFN-γ activity promotes widespread and sustained cytokine signaling altering the tumor microenvironment.

The immune system profoundly restricts intratumor genetic heterogeneity

A human immune system mouse model with robust lymph node development.

Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division

Intravital imaging reveals improved Kupffer cell-mediated phagocytosis as a mode of action of glycoengineered anti-CD20 antibodies.

The PD-1 Axis Enforces an Anatomical Segregation of CTL Activity that Creates Tumor Niches after Allogeneic Hematopoietic Stem Cell Transplantation

In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity

Signal strength regulates antigen-mediated T-cell deceleration by distinct mechanisms to promote local exploration or arrest

Immune responses against tumors

Dynamiques des Réponses Immunes

The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imaging

Synergy of the antibiotic colistin with echinocandin antifungals in Candida species

Dissecting T cell contraction in vivo using a genetically encoded reporter of apoptosis

Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles

Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis

The CD4⁺ T-cell help signal is transmitted from APC to CD8⁺ T-cells via CD27-CD70 interactions

Immune adjuvant efficacy of CpG oligonucleotide in cancer treatment is founded specifically upon TLR9 function in plasmacytoid dendritic cells

Selective expansion of merocytic dendritic cells and CD8DCs confers anti-tumour effect of Fms-like tyrosine kinase 3-ligand treatment in vivo

Visualizing the functional diversification of CD8+ T cell responses in lymph nodes

Prolonged antigen storage endows merocytic dendritic cells with enhanced capacity to prime anti-tumor responses in tumor-bearing mice

Dendritic cells use endocytic pathway for cross-priming class Ib MHC-restricted CD8alphaalpha+TCRalphabeta+ T cells with regulatory properties

Dendritic cell programming by cytomegalovirus stunts naive T cell responses via the PD-L1/PD-1 pathway

Chronic lymphocytic choriomeningitis virus infection actively down-regulates CD4+ T cell responses directed against a broad range of epitopes

Competition for antigen determines the stability of T cell-dendritic cell interactions during clonal expansion

Cutting edge: cognate CD4 help promotes recruitment of antigen-specific CD8 T cells around dendritic cells

Relationship between DNA methylation and histone acetylation levels, cell redox and cell differentiation states in sugarbeet lines

CD4 T cells integrate signals delivered during successive DC encounters in vivo

Lineage relationships, homeostasis, and recall capacities of central- and effector-memory CD8 T cells in vivo

Role of T cell help and endoplasmic reticulum targeting in protective CTL response against influenza virus

Human T cell leukemia virus Type I (HTLV-I) infection induces greater expansions of CD8 T lymphocytes in persons with HTLV-I-associated myelopathy/tropical spastic paraparesis than in asymptomatic carriers

H-2 class I knockout, HLA-A2.1-transgenic mice: a versatile animal model for preclinical evaluation of antitumor immunotherapeutic strategies

Molecular characterization of cDNAs encoding squirrel monkey (Saïmiri sciureus) CD8 alpha and beta chains

Cytotoxic T cell response against the chimeric p210 BCR-ABL protein in patients with chronic myelogenous leukemia

Restriction of self-antigen presentation to cytolytic T lymphocytes by mouse peptide pumps

Abrogation of H-2-restricted CTL responses and efficient recognition of HLA-A3 molecules in DBA/2 HLA/A24 responder mice