Timeline
Jean-Pierre Changeux
Honorary President of the Departement
23 Sep 2025
publication
The alpha7 nicotinic acetylcholine receptor mediates network dysfunction in a mouse model of local amyloid pathology.
Read more03 Jul 2025
05 Sep 2024
news
New publication – The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level
Read more12 Feb 2024
publication
The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level.
Read more28 Feb 2023
27 Feb 2023
27 Feb 2023
13 Feb 2023
publication
Illumination of a progressive allosteric mechanism mediating the glycine receptor activation.
Read more14 Oct 2022
publication
Lateral fenestrations in the extracellular domain of the glycine receptor contribute to the main chloride permeation pathway.
Read more16 Feb 2022
14 Dec 2021
26 Nov 2021
23 Nov 2021
publication
Inhibitory control of synaptic signals preceding locomotion in mouse frontal cortex.
Read more24 Sep 2021
09 Aug 2021
publication
Attenuation of clinical and immunological outcomes during SARS-CoV-2 infection by ivermectin.
Read more29 Jul 2021
26 Jul 2021
01 Jun 2021
31 Mar 2021
19 Jan 2021
publication
The natural axis of transmitter receptor distribution in the human cerebral cortex.
Read more01 Aug 2020
08 Jul 2020
05 Jun 2020
publication
A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications.
Read more01 Jun 2020
03 Apr 2020
publication
Discovery of the First Neurotransmitter Receptor: The Acetylcholine Nicotinic Receptor.
Read more04 Mar 2020
04 Feb 2020
publication
A strategy for designing allosteric modulators of transcription factor dimerization.
Read more01 Jan 2020
publication
The Molecular Organization of Self-awareness: Paralimbic Dopamine-GABA Interaction.
Read more07 Feb 2019
19 Nov 2018
19 Jun 2018
19 Apr 2018
project
The use of computational methods to design drugs – Human Brain Project Specific Grant Agreement 1
Read more01 Feb 2018
25 Oct 2017
publication
Un-gating and allosteric modulation of a pentameric ligand-gated ion channel captured by molecular dynamics
Read more01 Sep 2017
publication
Allosteric modulation as a unifying mechanism for receptor function and regulation
Read more25 Jul 2017
01 Feb 2017
20 Dec 2016
publication
Nicotinic receptors in mouse prefrontal cortex modulate ultraslow fluctuations related to conscious processing.
Read more23 Dec 2013
publication
Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation
Read more06 Jun 2012
publication
Structure and pharmacology of pentameric receptor channels: from bacteria to brain
Read more20 Jan 2011
publication
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
Read more22 Mar 2010
publication
One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue
Read more01 Apr 2005
publication
Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism
Read more01 Jan 1989