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© Research
Publication : Trends in cognitive sciences

Climbing Brain Levels of Organisation from Genes to Consciousness

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Trends in cognitive sciences - 01 Feb 2017

Changeux JP

Link to Pubmed [PMID] – 28161289

Trends Cogn. Sci. (Regul. Ed.) 2017 03;21(3):168-181

Given the tremendous complexity of brain organisation, here I propose a strategy that dynamically links stages of brain organisation from genes to consciousness, at four privileged structural levels: genes; transcription factors (TFs)-gene networks; synaptic epigenesis; and long-range connectivity. These structures are viewed as nested and reciprocally inter-regulated, with a hierarchical organisation that proceeds on different timescales during the course of evolution and development. Interlevel bridging mechanisms include intrinsic variation-selection mechanisms, which offer a community of bottom-up and top-down models linking genes to consciousness in a stepwise manner.

https://www.ncbi.nlm.nih.gov/pubmed/28161289