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© Research
Publication : Clinical and laboratory haematology

An evaluation of the Coulter VCS differential counter.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Clinical and laboratory haematology - 01 Jan 1989

Barnard DF, Barnard SA, Carter AB, Patterson KG, Yardumian A, Machin SJ,

Link to Pubmed [PMID] – 2591156

Clin Lab Haematol 1989 ; 11(3): 255-66

An evaluation of the Coulter VCS (volume, conductivity, light scatter) automated differential counter demonstrated satisfactory correlations with manual 800-cell differential counts for neutrophils, lymphocytes, monocytes and eosinophils. For the detection of abnormal cells, 12.2% of samples gave false-negative results on the VCS, and 13.4% gave false-positive results. However, only 0.8% of the false-negatives would be expected to be picked up by a standard 100-cell manual differential count. Carry-over accorded to manufacturer’s specifications and throughput was 60 samples/h. Reference normal ranges have been established and the instrument’s precision and performance with leucopenic and neonatal blood samples assessed.

https://pubmed.ncbi.nlm.nih.gov/2591156