Ligne de temps
Jean-Pierre Changeux
Président(e) d'honneur de Département
23 sept. 2025
publication
The alpha7 nicotinic acetylcholine receptor mediates network dysfunction in a mouse model of local amyloid pathology.
Lire plus03 juil. 2025
05 sept. 2024
news
New publication – The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level
Lire plus12 févr. 2024
publication
The Nicotinic Acetylcholine Receptor and its Pentameric Homologs: Toward an Allosteric Mechanism of Signal Transduction at the Atomic Level.
Lire plus28 févr. 2023
27 févr. 2023
27 févr. 2023
13 févr. 2023
publication
Illumination of a progressive allosteric mechanism mediating the glycine receptor activation.
Lire plus14 oct. 2022
publication
Lateral fenestrations in the extracellular domain of the glycine receptor contribute to the main chloride permeation pathway.
Lire plus16 févr. 2022
14 déc. 2021
26 nov. 2021
23 nov. 2021
publication
Inhibitory control of synaptic signals preceding locomotion in mouse frontal cortex.
Lire plus24 sept. 2021
09 août 2021
publication
Attenuation of clinical and immunological outcomes during SARS-CoV-2 infection by ivermectin.
Lire plus29 juil. 2021
26 juil. 2021
team
Modulation allostérique des récepteurs canaux pentamériques et relation avec le Covid 19
Lire plus01 juin 2021
31 mars 2021
19 janv. 2021
publication
The natural axis of transmitter receptor distribution in the human cerebral cortex.
Lire plus01 août 2020
08 juil. 2020
05 juin 2020
publication
A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications.
Lire plus01 juin 2020
03 avr. 2020
publication
Discovery of the First Neurotransmitter Receptor: The Acetylcholine Nicotinic Receptor.
Lire plus04 mars 2020
04 févr. 2020
publication
A strategy for designing allosteric modulators of transcription factor dimerization.
Lire plus01 janv. 2020
publication
The Molecular Organization of Self-awareness: Paralimbic Dopamine-GABA Interaction.
Lire plus07 févr. 2019
19 nov. 2018
19 juin 2018
19 avr. 2018
project
The use of computational methods to design drugs – Human Brain Project Specific Grant Agreement 1
Lire plus01 févr. 2018
25 oct. 2017
publication
Un-gating and allosteric modulation of a pentameric ligand-gated ion channel captured by molecular dynamics
Lire plus01 sept. 2017
publication
Allosteric modulation as a unifying mechanism for receptor function and regulation
Lire plus25 juil. 2017
01 févr. 2017
20 déc. 2016
publication
Nicotinic receptors in mouse prefrontal cortex modulate ultraslow fluctuations related to conscious processing.
Lire plus23 déc. 2013
publication
Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation
Lire plus06 juin 2012
publication
Structure and pharmacology of pentameric receptor channels: from bacteria to brain
Lire plus20 janv. 2011
publication
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel
Lire plus22 mars 2010
publication
One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue
Lire plus01 avr. 2005
publication
Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism
Lire plus01 janv. 1989