Timeline

Miria Ricchetti
Group Leader
08 Sep 2023
publication

Epigenomic signature of accelerated ageing in progeroid Cockayne syndrome.

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03 Jul 2023
publication

DNA-PKcs regulates myogenesis in an Akt-dependent manner independent of induced DNA damage.

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17 May 2023
event

25th International Conference of the Redox Medicine Society

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30 Aug 2022
news

New publication – Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia/IUGR consequences

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30 Jul 2022
publication

Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia/IUGR consequences.

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01 Jul 2022
publication

Reactive Species in Progeroid Syndromes and Aging-Related Processes.

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31 May 2022
event

Paris Redox 2022

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13 May 2022
publication

Polymerase ζ Is Involved in Mitochondrial DNA Maintenance Processes in Concert with APE1 Activity.

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05 Mar 2022
publication

Heterogeneous clinical features in Cockayne syndrome patients and siblings carrying the same CSA mutations.

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11 Jan 2022
event

DSCB seminar – Dr. Martin Feelisch, Faculty of Medicine, University of Southampton, UK – “Reactive Species in Stress Signalling – From Single Cells to the Whole Organism”

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29 Nov 2021
publication

Identification and Characterization of a Novel Recurrent ERCC6 Variant in Patients with a Severe Form of Cockayne Syndrome B.

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01 Jan 2021
publication

mTRIP, an Imaging Tool to Investigate Mitochondrial DNA Dynamics in Physiology and Disease at the Single-Cell Resolution.

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06 Dec 2019
publication

CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence.

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25 Mar 2019
event

Developmental and Stem Cell Biology Department seminar by: Professor Juan-Carlos Izpisua Belmonte, Salk Institute for Biological Studies, La Jolla California

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05 Feb 2019
publication

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.

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07 Sep 2018
event

Extra seminar by Francesco Saverio Tedesco, University College London: “Reprogramming stem cell-based strategies for skeletal muscle repair and (re)generation”

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05 Sep 2018
event

PhD Thesis defense: “Implication of DNA damage and repair in viability and differentiation of muscle stem cells”

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27 Jul 2018
publication

Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis

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12 Jun 2018
publication

Correction: Endonuclease G promotes mitochondrial genome cleavage and replication.

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06 Apr 2018
publication

Endonuclease G promotes mitochondrial genome cleavage and replication.

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01 Mar 2018
publication

Replication stress in mitochondria.

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15 Feb 2018
publication

Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53.

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01 Jan 2018
publication

Loss of heterogeneity, quiescence, and differentiation in muscle stem cells.

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21 Nov 2017
publication

Helicobacter pylori targets mitochondrial import and components of mitochondrial DNA replication machinery through an alternative VacA-dependent and a VacA-independent mechanisms.

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01 Oct 2017
publication

A novel paradigm links mitochondrial dysfunction with muscle stem cell impairment in sepsis.

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16 Feb 2017
program_project

Ageing & Longevity

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01 Sep 2016
publication

How stem cells manage to escape senescence and ageing – while they can: A recent study reveals that autophagy is responsible for senescence-dependent loss of regenerative potential of muscle stem cells during ageing.

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24 May 2016
project

DNA repair in muscle stem cells and during cell differentiation

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24 May 2016
event

17th International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants

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24 May 2016
project

Mechanism of ageing and progeroid diseases

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01 Jan 2016
publication

A Single-Cell Resolution Imaging Protocol of Mitochondrial DNA Dynamics in Physiopathology, mTRIP, Which Also Evaluates Sublethal Cytotoxicity.

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15 Dec 2015
publication

Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy

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13 Oct 2015
project

Muscle Stem Cells & Sepsis

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16 Jul 2015
team

Molecular Mechanisms of Pathological and Physiological Ageing

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02 Jun 2015
publication

Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome.

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01 Jan 2015
publication

mTRIP: an imaging tool to investigate mitochondrial DNA dynamics in physiology and disease at the single-cell resolution.

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01 Nov 2014
publication

Replication of mitochondrial DNA: the art of staying paired to avoid dangerous changes (comment on DOI 10.1002/bies.201400052).

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01 Nov 2014
publication

More efficient repair of DNA double-strand breaks in skeletal muscle stem cells compared to their committed progeny.

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01 Aug 2014
publication

Are mitochondria the Achilles’ heel of the Kingdom Fungi?

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20 Jun 2014
publication

Nitroso-redox balance and mitochondrial homeostasis are regulated by STOX1, a pre-eclampsia-associated gene

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01 Mar 2013
publication

Prevalent coordination of mitochondrial DNA transcription and initiation of replication with the cell cycle.

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15 Feb 2013
publication

Large heterogeneity of mitochondrial DNA transcription and initiation of replication exposed by single-cell imaging.

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12 Jun 2012
publication

Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity.

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02 Jan 2012
publication

DNA polymerase μ is a global player in the repair of non-homologous end-joining substrates.

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08 Mar 2011
publication

Nuclear mitochondrial DNA activates replication in Saccharomyces cerevisiae.

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10 Nov 2010
publication

Lack of DNA polymerase μ affects the kinetics of DNA double-strand break repair and impacts on cellular senescence.

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02 Feb 2010
publication

An end-joining repair mechanism in Escherichia coli.

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01 Feb 2008
publication

Low joining efficiency and non-conservative repair of two distant double-strand breaks in mouse embryonic stem cells.

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01 Sep 2004
publication

Continued colonization of the human genome by mitochondrial DNA.

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01 Jan 2004
publication

Large-scale exploration of growth inhibition caused by overexpression of genomic fragments in Saccharomyces cerevisiae.

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09 May 2003
publication

Distance from the chromosome end determines the efficiency of double strand break repair in subtelomeres of haploid yeast.

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01 Nov 1999
publication

Mitochondrial DNA repairs double-strand breaks in yeast chromosomes

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15 Aug 1997
publication

Telomerase activity of reverse transcriptase

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26 Nov 1996
publication

A reiterative mode of DNA synthesis adopted by HIV-1 reverse transcriptase after a misincorporation

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18 Jul 1995
publication

Homologous recombination promoted by reverse transcriptase during copying of two distinct RNA templates

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01 Jun 1993
publication

Comparison of interactions of 5′-derivatives of deoxyoctathymidylate with human DNA polymerize alpha and HIV reverse transcriptase

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01 Feb 1993
publication

E. coli DNA polymerase I as a reverse transcriptase

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01 May 1990
publication

Reverse transcriptases and genomic variability: the accuracy of DNA replication is enzyme specific and sequence dependent

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20 Dec 1988
publication

DNA-dependent RNA polymerase of Escherichia coli induces bending or an increased flexibility of DNA by specific complex formation

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01 Jul 1988
publication

One-dimensional diffusion of Escherichia coli DNA-dependent RNA polymerase: a mechanism to facilitate promoter location

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01 Jan 1984
publication

Piliated Bacteroides fragilis strains adhere to epithelial cells and are more sensitive to phagocytosis by human neutrophils than nonpiliated strains

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