Timeline

Miria Ricchetti

Group Leader

08 Sep 2023

publication

Epigenomic signature of accelerated ageing in progeroid Cockayne syndrome.

03 Jul 2023

publication

DNA-PKcs regulates myogenesis in an Akt-dependent manner independent of induced DNA damage.

17 May 2023

event

25th International Conference of the Redox Medicine Society

30 Aug 2022

news

New publication – Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia/IUGR consequences

30 Jul 2022

publication

Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia/IUGR consequences.

01 Jul 2022

publication

Reactive Species in Progeroid Syndromes and Aging-Related Processes.

31 May 2022

event

Paris Redox 2022

13 May 2022

publication

Polymerase ζ Is Involved in Mitochondrial DNA Maintenance Processes in Concert with APE1 Activity.

05 Mar 2022

publication

Heterogeneous clinical features in Cockayne syndrome patients and siblings carrying the same CSA mutations.

11 Jan 2022

event

DSCB seminar – Dr. Martin Feelisch, Faculty of Medicine, University of Southampton, UK – “Reactive Species in Stress Signalling – From Single Cells to the Whole Organism”

29 Nov 2021

publication

Identification and Characterization of a Novel Recurrent ERCC6 Variant in Patients with a Severe Form of Cockayne Syndrome B.

01 Jan 2021

publication

mTRIP, an Imaging Tool to Investigate Mitochondrial DNA Dynamics in Physiology and Disease at the Single-Cell Resolution.

06 Dec 2019

publication

CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence.

25 Mar 2019

event

Developmental and Stem Cell Biology Department seminar by: Professor Juan-Carlos Izpisua Belmonte, Salk Institute for Biological Studies, La Jolla California

05 Feb 2019

publication

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.

07 Sep 2018

event

Extra seminar by Francesco Saverio Tedesco, University College London: “Reprogramming stem cell-based strategies for skeletal muscle repair and (re)generation”

05 Sep 2018

event

PhD Thesis defense: “Implication of DNA damage and repair in viability and differentiation of muscle stem cells”

27 Jul 2018

publication

Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis

12 Jun 2018

publication

Correction: Endonuclease G promotes mitochondrial genome cleavage and replication.

06 Apr 2018

publication

Endonuclease G promotes mitochondrial genome cleavage and replication.

01 Mar 2018

publication

Replication stress in mitochondria.

15 Feb 2018

publication

Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53.

01 Jan 2018

publication

Loss of heterogeneity, quiescence, and differentiation in muscle stem cells.

21 Nov 2017

publication

Helicobacter pylori targets mitochondrial import and components of mitochondrial DNA replication machinery through an alternative VacA-dependent and a VacA-independent mechanisms.

01 Oct 2017

publication

A novel paradigm links mitochondrial dysfunction with muscle stem cell impairment in sepsis.

16 Feb 2017

program_project

Ageing & Longevity

01 Sep 2016

publication

How stem cells manage to escape senescence and ageing – while they can: A recent study reveals that autophagy is responsible for senescence-dependent loss of regenerative potential of muscle stem cells during ageing.

24 May 2016

project

DNA repair in muscle stem cells and during cell differentiation

24 May 2016

event

17th International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants

24 May 2016

project

Mechanism of ageing and progeroid diseases

01 Jan 2016

publication

A Single-Cell Resolution Imaging Protocol of Mitochondrial DNA Dynamics in Physiopathology, mTRIP, Which Also Evaluates Sublethal Cytotoxicity.

15 Dec 2015

publication

Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy

13 Oct 2015

project

Muscle Stem Cells & Sepsis

16 Jul 2015

team

Molecular Mechanisms of Pathological and Physiological Ageing

02 Jun 2015

publication

Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome.

01 Jan 2015

publication

mTRIP: an imaging tool to investigate mitochondrial DNA dynamics in physiology and disease at the single-cell resolution.

01 Nov 2014

publication

More efficient repair of DNA double-strand breaks in skeletal muscle stem cells compared to their committed progeny.

01 Nov 2014

publication

Replication of mitochondrial DNA: the art of staying paired to avoid dangerous changes (comment on DOI 10.1002/bies.201400052).

01 Aug 2014

publication

Are mitochondria the Achilles’ heel of the Kingdom Fungi?

20 Jun 2014

publication

Nitroso-redox balance and mitochondrial homeostasis are regulated by STOX1, a pre-eclampsia-associated gene

01 Mar 2013

publication

Prevalent coordination of mitochondrial DNA transcription and initiation of replication with the cell cycle.

15 Feb 2013

publication

Large heterogeneity of mitochondrial DNA transcription and initiation of replication exposed by single-cell imaging.

12 Jun 2012

publication

Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity.

02 Jan 2012

publication

DNA polymerase μ is a global player in the repair of non-homologous end-joining substrates.

08 Mar 2011

publication

Nuclear mitochondrial DNA activates replication in Saccharomyces cerevisiae.

10 Nov 2010

publication

Lack of DNA polymerase μ affects the kinetics of DNA double-strand break repair and impacts on cellular senescence.

02 Feb 2010

publication

An end-joining repair mechanism in Escherichia coli.

01 Feb 2008

publication

Low joining efficiency and non-conservative repair of two distant double-strand breaks in mouse embryonic stem cells.

01 Sep 2004

publication

Continued colonization of the human genome by mitochondrial DNA.

01 Jan 2004

publication

Large-scale exploration of growth inhibition caused by overexpression of genomic fragments in Saccharomyces cerevisiae.

09 May 2003

publication

Distance from the chromosome end determines the efficiency of double strand break repair in subtelomeres of haploid yeast.

01 Nov 1999

publication

Mitochondrial DNA repairs double-strand breaks in yeast chromosomes

15 Aug 1997

publication

Telomerase activity of reverse transcriptase

26 Nov 1996

publication

A reiterative mode of DNA synthesis adopted by HIV-1 reverse transcriptase after a misincorporation

18 Jul 1995

publication

Homologous recombination promoted by reverse transcriptase during copying of two distinct RNA templates

01 Jun 1993

publication

Comparison of interactions of 5′-derivatives of deoxyoctathymidylate with human DNA polymerize alpha and HIV reverse transcriptase

01 Feb 1993

publication

E. coli DNA polymerase I as a reverse transcriptase

01 May 1990

publication

Reverse transcriptases and genomic variability: the accuracy of DNA replication is enzyme specific and sequence dependent

20 Dec 1988

publication

DNA-dependent RNA polymerase of Escherichia coli induces bending or an increased flexibility of DNA by specific complex formation

01 Jul 1988

publication

One-dimensional diffusion of Escherichia coli DNA-dependent RNA polymerase: a mechanism to facilitate promoter location

01 Jan 1984

publication

A little guide for advanced search:

Epigenomic signature of accelerated ageing in progeroid Cockayne syndrome.

DNA-PKcs regulates myogenesis in an Akt-dependent manner independent of induced DNA damage.

25th International Conference of the Redox Medicine Society

New publication – Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia/IUGR consequences

Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia/IUGR consequences.

Reactive Species in Progeroid Syndromes and Aging-Related Processes.

Paris Redox 2022

Polymerase ζ Is Involved in Mitochondrial DNA Maintenance Processes in Concert with APE1 Activity.

Heterogeneous clinical features in Cockayne syndrome patients and siblings carrying the same CSA mutations.

DSCB seminar – Dr. Martin Feelisch, Faculty of Medicine, University of Southampton, UK – “Reactive Species in Stress Signalling – From Single Cells to the Whole Organism”

Identification and Characterization of a Novel Recurrent ERCC6 Variant in Patients with a Severe Form of Cockayne Syndrome B.

mTRIP, an Imaging Tool to Investigate Mitochondrial DNA Dynamics in Physiology and Disease at the Single-Cell Resolution.

CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence.

Developmental and Stem Cell Biology Department seminar by: Professor Juan-Carlos Izpisua Belmonte, Salk Institute for Biological Studies, La Jolla California

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells.

Extra seminar by Francesco Saverio Tedesco, University College London: “Reprogramming stem cell-based strategies for skeletal muscle repair and (re)generation”

PhD Thesis defense: “Implication of DNA damage and repair in viability and differentiation of muscle stem cells”

Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis

Correction: Endonuclease G promotes mitochondrial genome cleavage and replication.

Endonuclease G promotes mitochondrial genome cleavage and replication.

Replication stress in mitochondria.

Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53.

Loss of heterogeneity, quiescence, and differentiation in muscle stem cells.

Helicobacter pylori targets mitochondrial import and components of mitochondrial DNA replication machinery through an alternative VacA-dependent and a VacA-independent mechanisms.

A novel paradigm links mitochondrial dysfunction with muscle stem cell impairment in sepsis.

Ageing & Longevity

How stem cells manage to escape senescence and ageing – while they can: A recent study reveals that autophagy is responsible for senescence-dependent loss of regenerative potential of muscle stem cells during ageing.

DNA repair in muscle stem cells and during cell differentiation

17th International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants

Mechanism of ageing and progeroid diseases

A Single-Cell Resolution Imaging Protocol of Mitochondrial DNA Dynamics in Physiopathology, mTRIP, Which Also Evaluates Sublethal Cytotoxicity.

Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy

Muscle Stem Cells & Sepsis

Molecular Mechanisms of Pathological and Physiological Ageing

Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome.

mTRIP: an imaging tool to investigate mitochondrial DNA dynamics in physiology and disease at the single-cell resolution.

More efficient repair of DNA double-strand breaks in skeletal muscle stem cells compared to their committed progeny.

Replication of mitochondrial DNA: the art of staying paired to avoid dangerous changes (comment on DOI 10.1002/bies.201400052).

Are mitochondria the Achilles’ heel of the Kingdom Fungi?

Nitroso-redox balance and mitochondrial homeostasis are regulated by STOX1, a pre-eclampsia-associated gene

Prevalent coordination of mitochondrial DNA transcription and initiation of replication with the cell cycle.

Large heterogeneity of mitochondrial DNA transcription and initiation of replication exposed by single-cell imaging.

Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity.

DNA polymerase μ is a global player in the repair of non-homologous end-joining substrates.

Nuclear mitochondrial DNA activates replication in Saccharomyces cerevisiae.

Lack of DNA polymerase μ affects the kinetics of DNA double-strand break repair and impacts on cellular senescence.

An end-joining repair mechanism in Escherichia coli.

Low joining efficiency and non-conservative repair of two distant double-strand breaks in mouse embryonic stem cells.

Continued colonization of the human genome by mitochondrial DNA.

Large-scale exploration of growth inhibition caused by overexpression of genomic fragments in Saccharomyces cerevisiae.

Distance from the chromosome end determines the efficiency of double strand break repair in subtelomeres of haploid yeast.

Mitochondrial DNA repairs double-strand breaks in yeast chromosomes

Telomerase activity of reverse transcriptase

A reiterative mode of DNA synthesis adopted by HIV-1 reverse transcriptase after a misincorporation

Homologous recombination promoted by reverse transcriptase during copying of two distinct RNA templates

Comparison of interactions of 5′-derivatives of deoxyoctathymidylate with human DNA polymerize alpha and HIV reverse transcriptase

E. coli DNA polymerase I as a reverse transcriptase

Reverse transcriptases and genomic variability: the accuracy of DNA replication is enzyme specific and sequence dependent

DNA-dependent RNA polymerase of Escherichia coli induces bending or an increased flexibility of DNA by specific complex formation

One-dimensional diffusion of Escherichia coli DNA-dependent RNA polymerase: a mechanism to facilitate promoter location

Piliated Bacteroides fragilis strains adhere to epithelial cells and are more sensitive to phagocytosis by human neutrophils than nonpiliated strains