Timeline

Miria Ricchetti

Group Leader

06 Dec 2019

publication

CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence

25 Mar 2019

event

Developmental and Stem Cell Biology Department seminar by: Professor Juan-Carlos Izpisua Belmonte, Salk Institute for Biological Studies, La Jolla California

09 Nov 2018

publication

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

07 Sep 2018

event

Extra seminar by Francesco Saverio Tedesco, University College London: “Reprogramming stem cell-based strategies for skeletal muscle repair and (re)generation”

05 Sep 2018

event

PhD Thesis defense: “Implication of DNA damage and repair in viability and differentiation of muscle stem cells”

27 Jul 2018

publication

Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis

12 Apr 2018

publication

Loss of heterogeneity, quiescence, and differentiation in muscle stem cells

06 Apr 2018

publication

Endonuclease G promotes mitochondrial genome cleavage and replication

15 Feb 2018

publication

Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53

01 Feb 2018

publication

Replication stress in mitochondria

21 Nov 2017

publication

Helicobacter pylori targets mitochondrial import and components of mitochondrial DNA replication machinery through an alternative VacA-dependent and a VacA-independent mechanisms

27 Apr 2017

publication

A novel paradigm links mitochondrial dysfunction with muscle stem cell impairment in sepsis

08 Jul 2016

publication

How stem cells manage to escape senescence and ageing – while they can: A recent study reveals that autophagy is responsible for senescence-dependent loss of regenerative potential of muscle stem cells during ageing

24 May 2016

project

DNA repair in muscle stem cells and during cell differentiation

24 May 2016

event

17th International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants

24 May 2016

project

Mechanism of ageing and progeroid diseases

01 Jan 2016

publication

A Single-Cell Resolution Imaging Protocol of Mitochondrial DNA Dynamics in Physiopathology, mTRIP, Which Also Evaluates Sublethal Cytotoxicity

15 Dec 2015

publication

Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy

13 Oct 2015

project

Muscle Stem Cells & Sepsis

16 Jul 2015

team

Group: Miria Ricchetti

18 May 2015

publication

Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome

11 May 2015

team

Stem Cells And Development

01 Jan 2015

publication

mTRIP: an imaging tool to investigate mitochondrial DNA dynamics in physiology and disease at the single-cell resolution

01 Nov 2014

publication

Replication of mitochondrial DNA: the art of staying paired to avoid dangerous changes (comment on DOI 10.1002/bies.201400052)

26 Aug 2014

publication

More efficient repair of DNA double-strand breaks in skeletal muscle stem cells compared to their committed progeny

20 Jun 2014

publication

Nitroso-redox balance and mitochondrial homeostasis are regulated by STOX1, a pre-eclampsia-associated gene

04 Jun 2014

publication

Are mitochondria the Achilles’ heel of the Kingdom Fungi?

23 Jan 2013

publication

Prevalent coordination of mitochondrial DNA transcription and initiation of replication with the cell cycle

13 Dec 2012

publication

Large heterogeneity of mitochondrial DNA transcription and initiation of replication exposed by single-cell imaging

12 Jun 2012

publication

Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity

08 Nov 2011

publication

DNA polymerase μ is a global player in the repair of non-homologous end-joining substrates

08 Mar 2011

publication

Nuclear mitochondrial DNA activates replication in Saccharomyces cerevisiae

14 Oct 2010

publication

Lack of DNA polymerase μ affects the kinetics of DNA double-strand break repair and impacts on cellular senescence

19 Jan 2010

publication

An end-joining repair mechanism in Escherichia coli

26 Oct 2007

publication

Low joining efficiency and non-conservative repair of two distant double-strand breaks in mouse embryonic stem cells

07 Sep 2004

publication

Continued colonization of the human genome by mitochondrial DNA

01 May 2003

publication

Distance from the chromosome end determines the efficiency of double strand break repair in subtelomeres of haploid yeast

01 Nov 1999

publication

Mitochondrial DNA repairs double-strand breaks in yeast chromosomes

15 Aug 1997

publication

Telomerase activity of reverse transcriptase

26 Nov 1996

publication

A reiterative mode of DNA synthesis adopted by HIV-1 reverse transcriptase after a misincorporation

18 Jul 1995

publication

Homologous recombination promoted by reverse transcriptase during copying of two distinct RNA templates

01 Jun 1993

publication

Comparison of interactions of 5′-derivatives of deoxyoctathymidylate with human DNA polymerize alpha and HIV reverse transcriptase

01 Feb 1993

publication

E. coli DNA polymerase I as a reverse transcriptase

01 May 1990

publication

Reverse transcriptases and genomic variability: the accuracy of DNA replication is enzyme specific and sequence dependent

20 Dec 1988

publication

DNA-dependent RNA polymerase of Escherichia coli induces bending or an increased flexibility of DNA by specific complex formation

01 Jul 1988

publication

One-dimensional diffusion of Escherichia coli DNA-dependent RNA polymerase: a mechanism to facilitate promoter location

01 Jan 1984

publication

A little guide for advanced search:

CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence

Developmental and Stem Cell Biology Department seminar by: Professor Juan-Carlos Izpisua Belmonte, Salk Institute for Biological Studies, La Jolla California

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

Extra seminar by Francesco Saverio Tedesco, University College London: “Reprogramming stem cell-based strategies for skeletal muscle repair and (re)generation”

PhD Thesis defense: “Implication of DNA damage and repair in viability and differentiation of muscle stem cells”

Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis

Loss of heterogeneity, quiescence, and differentiation in muscle stem cells

Endonuclease G promotes mitochondrial genome cleavage and replication

Mitochondrial MDM2 Regulates Respiratory Complex I Activity Independently of p53

Replication stress in mitochondria

Helicobacter pylori targets mitochondrial import and components of mitochondrial DNA replication machinery through an alternative VacA-dependent and a VacA-independent mechanisms

A novel paradigm links mitochondrial dysfunction with muscle stem cell impairment in sepsis

How stem cells manage to escape senescence and ageing – while they can: A recent study reveals that autophagy is responsible for senescence-dependent loss of regenerative potential of muscle stem cells during ageing

DNA repair in muscle stem cells and during cell differentiation

17th International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants

Mechanism of ageing and progeroid diseases

A Single-Cell Resolution Imaging Protocol of Mitochondrial DNA Dynamics in Physiopathology, mTRIP, Which Also Evaluates Sublethal Cytotoxicity

Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy

Muscle Stem Cells & Sepsis

Group: Miria Ricchetti

Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome

Stem Cells And Development

mTRIP: an imaging tool to investigate mitochondrial DNA dynamics in physiology and disease at the single-cell resolution

Replication of mitochondrial DNA: the art of staying paired to avoid dangerous changes (comment on DOI 10.1002/bies.201400052)

More efficient repair of DNA double-strand breaks in skeletal muscle stem cells compared to their committed progeny

Nitroso-redox balance and mitochondrial homeostasis are regulated by STOX1, a pre-eclampsia-associated gene

Are mitochondria the Achilles’ heel of the Kingdom Fungi?

Prevalent coordination of mitochondrial DNA transcription and initiation of replication with the cell cycle

Large heterogeneity of mitochondrial DNA transcription and initiation of replication exposed by single-cell imaging

Skeletal muscle stem cells adopt a dormant cell state post mortem and retain regenerative capacity

DNA polymerase μ is a global player in the repair of non-homologous end-joining substrates

Nuclear mitochondrial DNA activates replication in Saccharomyces cerevisiae

Lack of DNA polymerase μ affects the kinetics of DNA double-strand break repair and impacts on cellular senescence

An end-joining repair mechanism in Escherichia coli

Low joining efficiency and non-conservative repair of two distant double-strand breaks in mouse embryonic stem cells

Continued colonization of the human genome by mitochondrial DNA

Distance from the chromosome end determines the efficiency of double strand break repair in subtelomeres of haploid yeast

Mitochondrial DNA repairs double-strand breaks in yeast chromosomes

Telomerase activity of reverse transcriptase

A reiterative mode of DNA synthesis adopted by HIV-1 reverse transcriptase after a misincorporation

Homologous recombination promoted by reverse transcriptase during copying of two distinct RNA templates

Comparison of interactions of 5′-derivatives of deoxyoctathymidylate with human DNA polymerize alpha and HIV reverse transcriptase

E. coli DNA polymerase I as a reverse transcriptase

Reverse transcriptases and genomic variability: the accuracy of DNA replication is enzyme specific and sequence dependent

DNA-dependent RNA polymerase of Escherichia coli induces bending or an increased flexibility of DNA by specific complex formation

One-dimensional diffusion of Escherichia coli DNA-dependent RNA polymerase: a mechanism to facilitate promoter location

Piliated Bacteroides fragilis strains adhere to epithelial cells and are more sensitive to phagocytosis by human neutrophils than nonpiliated strains