Timeline

Elisabetta Bianchi

Group Leader

26 Aug 2024

event

Regulation of IL-23R Expression in Human CD4+ T Cells and the Impact of IL-23 Blockade on Immune Responses in Vivo

14 Feb 2022

publication

Characterization of Blood Mucosal Associated Invariant T (MAIT) cells in Axial Spondyloarthritis and of resident MAITs from control axial enthesis.

16 Dec 2021

project

SpA23 – Rôle de l’IL-23 dans les maladies chroniques inflammatoires : exploration des mécanismes cellulaires et moléculaires de la signalisation de l’IL-23 dans la spondylarthrite axiale et périphérique

16 Jul 2021

project

Pso23 – Exploration des mécanismes cellulaires et moléculaires de la réponse chez les patients recevant une biothérapie ciblant l’axe IL-23/IL-17 dans le psoriasis cutané

01 Apr 2021

publication

Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo.

01 Apr 2021

publication

Novel approaches to develop biomarkers predicting treatment responses to TNF-blockers.

01 Jan 2021

publication

Editorial: Role of the IL-23/IL-17 Pathway in Chronic Immune-Mediated Inflammatory Diseases: Mechanisms and Targeted Therapies.

25 Aug 2020

publication

Cellular and molecular profiling of T-cell subsets at the onset of human acute GVHD.

16 Oct 2019

publication

NFAT primes the human RORC locus for RORγt expression in CD4 T cells

25 Jun 2019

publication

The IL-23/IL-17 pathway in human chronic inflammatory diseases – new insight from genetics and targeted therapies

19 Apr 2019

publication

The IL-23/IL-17 pathway in human chronic inflammatory diseases-new insight from genetics and targeted therapies

19 Mar 2019

publication

Anti-TNF Therapy in Spondyloarthritis and Related Diseases, Impact on the Immune System and Prediction of Treatment Responses

14 Nov 2015

publication

Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients.

28 Jul 2015

patent

Seronegative spondyloarthropathy diagnosis and treatment (WO/2015/010744)

07 Jul 2015

project

Epigenetic mechanisms controlling the stability and plasticity of CD4+ T cell subsets

11 May 2015

team

Immunoregulation

02 Jun 2014

publication

RanBP9 overexpression accelerates loss of dendritic spines in a mouse model of Alzheimer’s disease

13 Jan 2014

publication

Dynamic regulation of the COP9 signalosome in response to DNA damage

01 Jan 2014

publication

RanBP9 overexpression down-regulates phospho-cofilin, causes early synaptic deficits and impaired learning, and accelerates accumulation of amyloid plaques in the mouse brain

07 Aug 2013

publication

COPS5 (Jab1) protein increases β site processing of amyloid precursor protein and amyloid β peptide generation by stabilizing RanBP9 protein levels

01 Jul 2013

publication

Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease

26 Jun 2013

publication

RanBP9 Plays a Critical Role in Neonatal Brain Development in Mice

13 Jun 2013

publication

RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer’s brain synaptosomes

01 Jun 2013

publication

Combinatorial control of Th17 and Th1 cell functions by genetic variations in genes associated with the interleukin-23 signaling pathway in spondyloarthritis

31 Jan 2012

publication

Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain

08 Apr 2010

publication

The human COP9 signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP)-mediated degradation

01 Jan 2010

publication

RanBPM regulates the progression of neuronal precursors through M-phase at the surface of the neocortical ventricular zone

15 Dec 2009

publication

Integration of distinct intracellular signaling pathways at distal regulatory elements directs T-bet expression in human CD4+ T cells

27 Sep 2009

publication

Regulation of mu opioid receptor internalization by the scaffold protein RanBPM

03 Sep 2009

publication

A fragment of the scaffolding protein RanBP9 is increased in Alzheimer’s disease brains and strongly potentiates amyloid-beta peptide generation

01 Jun 2009

publication

Genetic and epigenetic networks controlling T helper 1 cell differentiation

09 Mar 2009

publication

Heterotrimeric G proteins demonstrate differential sensitivity to beta-arrestin dependent desensitization

27 Feb 2009

publication

Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation

10 Apr 2008

publication

Enhancement of transactivation activity of Rta of Epstein-Barr virus by RanBPM

15 Feb 2007

publication

Chromatin remodeling by the SWI/SNF-like BAF complex and STAT4 activation synergistically induce IL-12Rbeta2 expression during human Th1 cell differentiation

01 Feb 2007

publication

COP9 signalosome subunit 5 (CSN5/Jab1) regulates the development of the Drosophila immune system: effects on Cactus, Dorsal and hematopoiesis

30 Aug 2006

publication

The COP9 signalosome regulates Skp2 levels and proliferation of human cells

04 Jan 2006

publication

An intracellular role for the C1q-globular domain

01 Jul 2004

publication

Expression pattern of the JAB1/CSN5 gene during murine embryogenesis: colocalization with NEDD8

13 Jan 2004

publication

RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1

24 Jul 2003

publication

Gene profiling of lymphoma, myeloma, and AML

21 Jul 2003

publication

Dissecting oncogenes and tyrosine kinases in AML cells

18 Jul 2003

publication

Antileukemic activity of natural killer cells in allogeneic BMT

03 Mar 2003

publication

Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity

01 May 2000

publication

Transcript imaging of the development of human T helper cells using oligonucleotide arrays

01 Apr 2000

publication

Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity

15 Sep 1999

publication

A tyrosine-based sorting signal in the beta2 integrin cytoplasmic domain mediates its recycling to the plasma membrane and is required for ligand-supported migration

01 May 1999

publication

Regulation of lymphocyte traffic by adhesion molecules

01 Dec 1997

publication

Through and beyond the wall: late steps in leukocyte transendothelial migration

01 Feb 1997

publication

A novel approach to the identification of genes involved in neo-angiogenesis: implications for graft re-vascularization

01 Sep 1996

publication

Integrin-dependent induction of functional urokinase receptors in primary T lymphocytes

01 Apr 1996

publication

CD31/PECAM-1-driven chemokine-independent transmigration of human T lymphocytes

01 Mar 1995

publication

Immunohistochemical localization of the plasminogen activator inhibitor-1 in breast cancer

15 Feb 1994

publication

The urokinase receptor is expressed in invasive breast cancer but not in normal breast tissue

01 Jan 1991

publication

Age-related changes in interleukin 2 responsiveness of resting and activated human mononuclear cells

01 Aug 1990

publication

Natural killer lines and clones with apparent antigen specificity

01 Jul 1989

publication

A little guide for advanced search:

Regulation of IL-23R Expression in Human CD4+ T Cells and the Impact of IL-23 Blockade on Immune Responses in Vivo

Characterization of Blood Mucosal Associated Invariant T (MAIT) cells in Axial Spondyloarthritis and of resident MAITs from control axial enthesis.

SpA23 – Rôle de l’IL-23 dans les maladies chroniques inflammatoires : exploration des mécanismes cellulaires et moléculaires de la signalisation de l’IL-23 dans la spondylarthrite axiale et périphérique

Pso23 – Exploration des mécanismes cellulaires et moléculaires de la réponse chez les patients recevant une biothérapie ciblant l’axe IL-23/IL-17 dans le psoriasis cutané

Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo.

Novel approaches to develop biomarkers predicting treatment responses to TNF-blockers.

Editorial: Role of the IL-23/IL-17 Pathway in Chronic Immune-Mediated Inflammatory Diseases: Mechanisms and Targeted Therapies.

Cellular and molecular profiling of T-cell subsets at the onset of human acute GVHD.

NFAT primes the human RORC locus for RORγt expression in CD4 T cells

The IL-23/IL-17 pathway in human chronic inflammatory diseases – new insight from genetics and targeted therapies

The IL-23/IL-17 pathway in human chronic inflammatory diseases-new insight from genetics and targeted therapies

Anti-TNF Therapy in Spondyloarthritis and Related Diseases, Impact on the Immune System and Prediction of Treatment Responses

Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients.

Seronegative spondyloarthropathy diagnosis and treatment (WO/2015/010744)

Epigenetic mechanisms controlling the stability and plasticity of CD4+ T cell subsets

Immunoregulation

RanBP9 overexpression accelerates loss of dendritic spines in a mouse model of Alzheimer’s disease

Dynamic regulation of the COP9 signalosome in response to DNA damage

RanBP9 overexpression down-regulates phospho-cofilin, causes early synaptic deficits and impaired learning, and accelerates accumulation of amyloid plaques in the mouse brain

COPS5 (Jab1) protein increases β site processing of amyloid precursor protein and amyloid β peptide generation by stabilizing RanBP9 protein levels

Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease

RanBP9 Plays a Critical Role in Neonatal Brain Development in Mice

RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer’s brain synaptosomes

Combinatorial control of Th17 and Th1 cell functions by genetic variations in genes associated with the interleukin-23 signaling pathway in spondyloarthritis

Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain

The human COP9 signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP)-mediated degradation

RanBPM regulates the progression of neuronal precursors through M-phase at the surface of the neocortical ventricular zone

Integration of distinct intracellular signaling pathways at distal regulatory elements directs T-bet expression in human CD4+ T cells

Regulation of mu opioid receptor internalization by the scaffold protein RanBPM

A fragment of the scaffolding protein RanBP9 is increased in Alzheimer’s disease brains and strongly potentiates amyloid-beta peptide generation

Genetic and epigenetic networks controlling T helper 1 cell differentiation

Heterotrimeric G proteins demonstrate differential sensitivity to beta-arrestin dependent desensitization

Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation

Enhancement of transactivation activity of Rta of Epstein-Barr virus by RanBPM

Chromatin remodeling by the SWI/SNF-like BAF complex and STAT4 activation synergistically induce IL-12Rbeta2 expression during human Th1 cell differentiation

COP9 signalosome subunit 5 (CSN5/Jab1) regulates the development of the Drosophila immune system: effects on Cactus, Dorsal and hematopoiesis

The COP9 signalosome regulates Skp2 levels and proliferation of human cells

An intracellular role for the C1q-globular domain

Expression pattern of the JAB1/CSN5 gene during murine embryogenesis: colocalization with NEDD8

RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1

Gene profiling of lymphoma, myeloma, and AML

Dissecting oncogenes and tyrosine kinases in AML cells

Antileukemic activity of natural killer cells in allogeneic BMT

Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity

Transcript imaging of the development of human T helper cells using oligonucleotide arrays

Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity

A tyrosine-based sorting signal in the beta2 integrin cytoplasmic domain mediates its recycling to the plasma membrane and is required for ligand-supported migration

Regulation of lymphocyte traffic by adhesion molecules

Through and beyond the wall: late steps in leukocyte transendothelial migration

A novel approach to the identification of genes involved in neo-angiogenesis: implications for graft re-vascularization

Integrin-dependent induction of functional urokinase receptors in primary T lymphocytes

CD31/PECAM-1-driven chemokine-independent transmigration of human T lymphocytes

Immunohistochemical localization of the plasminogen activator inhibitor-1 in breast cancer

The urokinase receptor is expressed in invasive breast cancer but not in normal breast tissue

Age-related changes in interleukin 2 responsiveness of resting and activated human mononuclear cells

Natural killer lines and clones with apparent antigen specificity

Interleukin 2 and mitogen driven proliferation in human peripheral mononuclear cells: a kinetic analysis