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© Research
Publication : Expert review of clinical immunology

Novel approaches to develop biomarkers predicting treatment responses to TNF-blockers.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Expert review of clinical immunology - 01 Apr 2021

Mezghiche I, Yahia-Cherbal H, Rogge L, Bianchi E,

Link to Pubmed [PMID] – 33622154

Link to DOI – 10.1080/1744666X.2021.1894926

Expert Rev Clin Immunol 2021 Apr; 17(4): 331-354

Introduction: Chronic inflammatory diseases (CIDs) cause significant morbidity and are a considerable burden for the patients in terms of pain, impaired function, and diminished quality of life. Important progress in CID treatment has been obtained with biological therapies, such as tumor-necrosis-factor blockers. However, more than a third of the patients fail to respond to these inhibitors and are exposed to the side effects of treatment, without the benefits. Therefore, there is a strong interest in developing tools to predict response of patients to biologics. Areas covered: The authors searched PubMed for recent studies on biomarkers for disease assessment and prediction of therapeutic responses, focusing on the effect of TNF blockers on immune responses in spondyloarthritis (SpA), and other CID, in particular rheumatoid arthritis and inflammatory bowel disease. Conclusions will be drawn about the possible development of predictive biomarkers for response to treatment. Expert opinion: No validated biomarker is currently available to predict treatment response in CID. New insight could be generated through the development of new bioinformatic modeling approaches to combine multidimensional biomarkers that explain the different genetic, immunological and environmental determinants of therapeutic responses.

https://pubmed.ncbi.nlm.nih.gov/33622154