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© Research
Publication : Immunology today

Through and beyond the wall: late steps in leukocyte transendothelial migration

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Immunology today - 01 Dec 1997

Bianchi E, Bender JR, Blasi F, Pardi R

Link to Pubmed [PMID] – 9425737

Immunol. Today 1997 Dec;18(12):586-91

A combination of approaches has provided firm experimental support for a step-wise model of leukocyte adhesion to vascular endothelium under hemodynamic shear stress. However, leukocyte adhesion to vascular endothelium acquires functional significance only if coupled to transmigration and progression into extravascular tissues. As discussed here by Elisabetta Bianchi and colleagues, these latter processes involve the sequential activation of adhesion-dependent functional programs, carried out by structurally diverse multimolecular complexes.

http://www.ncbi.nlm.nih.gov/pubmed/9425737