Timeline

Marco Bellinzoni
Permanent Researcher
10 Aug 2023
publication

High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase.

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25 Sep 2022
publication

Structural Basis for the Binding of Allosteric Activators Leucine and ADP to Mammalian Glutamate Dehydrogenase.

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22 Jun 2022
event

PhD Thesis :“ Integrative structural biology of a mixed PDH/ODH supercomplex from Corynebacterium glutamicum ”

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30 Nov 2021
publication

Actinobacteria challenge the paradigm: A unique protein architecture for a well-known, central metabolic complex.

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26 Oct 2021
publication

A Tetratricopeptide Repeat Scaffold Couples Signal Detection to OdhI Phosphorylation in Metabolic Control by the Protein Kinase PknG.

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30 Jul 2021
publication

Proteome remodeling in the Mycobacterium tuberculosis PknG knockout: Molecular evidence for the role of this kinase in cell envelope biogenesis and hypoxia response.

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09 Jul 2020
publication

Shedding X-ray Light on the Role of Magnesium in the Activity of Mycobacterium tuberculosis Salicylate Synthase (MbtI) for Drug Design.

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20 Jun 2020
publication

Structure-Based Drug Design for Tuberculosis: Challenges Still Ahead

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01 Jan 2020
publication

Selective Inhibition of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases by the Phosphonate Analogs of Their 2-Oxo Acid Substrates.

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01 Dec 2019
publication

New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents.

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01 Nov 2019
publication

Conformational transitions in the active site of mycobacterial 2-oxoglutarate dehydrogenase upon binding phosphonate analogues of 2-oxoglutarate: From a Michaelis-like complex to ThDP adducts.

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26 Jun 2019
publication

Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases.

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16 May 2019
project

METACTINO

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07 May 2019
publication

Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.

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01 May 2019
publication

Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases.

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10 Feb 2019
publication

New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach.

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16 Nov 2017
event

Prof. Michael BOTT – “Corynebacterium glutamicum – microbial cell factory and model organism for actinobacteria”

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17 May 2017
publication

PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.

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29 Jan 2017
publication

The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation.

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01 Sep 2016
publication

Ser/Thr Phosphorylation Regulates the Fatty Acyl-AMP Ligase Activity of FadD32, an Essential Enzyme in Mycolic Acid Biosynthesis.

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20 Jan 2016
project

MM4TB

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20 Jan 2016
project

SUPERCPLX

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02 Dec 2015
event

EMBO Conference Tuberculosis 2016

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16 Jul 2015
team

Structural biology of metabolic enzymes and complexes

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03 Jul 2015
project

PknA/PknB in mycobacterial cell division

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03 Jul 2015
project

Control of glutamate metabolism in mycobacteria

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18 Jun 2015
publication

Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.

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11 May 2015
team

Structural Microbiology

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25 Mar 2015
publication

The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation.

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17 Nov 2014
publication

Secondary structure reshuffling modulates glycosyltransferase function at the membrane.

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24 Sep 2014
publication

Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c.

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01 Feb 2014
publication

A dual conformation of the post-decarboxylation intermediate is associated with distinct enzyme states in mycobacterial KGD (α-ketoglutarate decarboxylase).

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08 Sep 2013
publication

GarA is an essential regulator of metabolism in Mycobacterium tuberculosis.

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11 Jan 2013
publication

Tolerance of the archaeal Sac7d scaffold protein to alternative library designs: characterization of anti-immunoglobulin G Affitins.

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10 Jan 2013
publication

Contactin 4, -5 and -6 differentially regulate neuritogenesis while they display identical PTPRG binding sites.

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03 May 2012
publication

Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.

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26 Aug 2011
publication

Functional plasticity and allosteric regulation of α-ketoglutarate decarboxylase in central mycobacterial metabolism.

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01 Jun 2011
publication

3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation.

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01 Sep 2010
publication

Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance.

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13 Apr 2010
publication

A novel role of malonyl-ACP in lipid homeostasis.

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15 Feb 2010
publication

Crystal structure of Mycobacterium tuberculosis LppA, a lipoprotein confined to pathogenic mycobacteria.

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09 Oct 2009
publication

Structural plasticity and distinct drug-binding modes of LfrR, a mycobacterial efflux pump regulator.

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18 Sep 2009
publication

Structure of Mycobacterium tuberculosis Rv2714, a representative of a duplicated gene family in Actinobacteria.

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15 Apr 2009
publication

Bacterial metabolism under FHA control.

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17 Oct 2008
publication

Regulation of glutamate metabolism by protein kinases in mycobacteria.

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02 Oct 2007
publication

Structural and binding studies of the three-metal center in two mycobacterial PPM Ser/Thr protein phosphatases.

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14 Aug 2007
publication

Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential.

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01 Jul 2007
publication

Insights into the catalytic mechanism of PPM Ser/Thr phosphatases from the atomic resolution structures of a mycobacterial enzyme.

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02 May 2006
publication

The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.

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27 Apr 2006
publication

The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria.

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01 Aug 2005
publication

Conserved autophosphorylation pattern in activation loops and juxtamembrane regions of Mycobacterium tuberculosis Ser/Thr protein kinases.

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01 Mar 2005
publication

Glutamine amidotransferase activity of NAD+ synthetase from Mycobacterium tuberculosis depends on an amino-terminal nitrilase domain.

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01 Aug 2004
publication

Rv2686c-Rv2687c-Rv2688c, an ABC fluoroquinolone efflux pump in Mycobacterium tuberculosis.

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01 Aug 2003
publication

Techniques and applications: The heterologous expression of Mycobacterium tuberculosis genes is an uphill road.

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01 Jan 2003
publication

The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology

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01 Nov 2002
publication

The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis.

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01 Oct 2002
publication

Reconstitution of T-cell receptor repertoire diversity following non-myeloablative allogeneic stem cell transplantation in an acute myeloid leukemia patient.

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01 Sep 2002
publication

High prevalence of a variant of SENV in intravenous drug user HIV-infected patients.

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01 Aug 2002
publication

Heterologous expression, purification, and enzymatic activity of Mycobacterium tuberculosis NAD(+) synthetase.

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01 Mar 2002
publication

Transmission of SEN virus from mothers to their babies.

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