Ligne de temps
Marco Bellinzoni
Chercheur(euse) Permanent(e)
30 juil. 2024
publication
Corynebacterium glutamicum pyruvate:quinone oxidoreductase: an enigmatic metabolic enzyme with unusual structural features
Lire plus10 août 2023
publication
High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase.
Lire plus25 sept. 2022
publication
Structural Basis for the Binding of Allosteric Activators Leucine and ADP to Mammalian Glutamate Dehydrogenase.
Lire plus22 juin 2022
event
PhD Thesis :“ Integrative structural biology of a mixed PDH/ODH supercomplex from Corynebacterium glutamicum ”
Lire plus30 nov. 2021
publication
Actinobacteria challenge the paradigm: A unique protein architecture for a well-known, central metabolic complex.
Lire plus26 oct. 2021
publication
A Tetratricopeptide Repeat Scaffold Couples Signal Detection to OdhI Phosphorylation in Metabolic Control by the Protein Kinase PknG.
Lire plus30 juil. 2021
publication
Proteome remodeling in the Mycobacterium tuberculosis PknG knockout: Molecular evidence for the role of this kinase in cell envelope biogenesis and hypoxia response.
Lire plus09 juil. 2020
publication
Shedding X-ray Light on the Role of Magnesium in the Activity of Mycobacterium tuberculosis Salicylate Synthase (MbtI) for Drug Design.
Lire plus20 juin 2020
01 janv. 2020
publication
Selective Inhibition of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases by the Phosphonate Analogs of Their 2-Oxo Acid Substrates.
Lire plus01 déc. 2019
publication
New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents.
Lire plus01 nov. 2019
publication
Conformational transitions in the active site of mycobacterial 2-oxoglutarate dehydrogenase upon binding phosphonate analogues of 2-oxoglutarate: From a Michaelis-like complex to ThDP adducts.
Lire plus26 juin 2019
publication
Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases.
Lire plus16 mai 2019
07 mai 2019
publication
Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.
Lire plus01 mai 2019
publication
Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases.
Lire plus10 févr. 2019
publication
New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach.
Lire plus16 nov. 2017
event
Prof. Michael BOTT – “Corynebacterium glutamicum – microbial cell factory and model organism for actinobacteria”
Lire plus17 mai 2017
publication
PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.
Lire plus29 janv. 2017
publication
The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation.
Lire plus01 sept. 2016
publication
Ser/Thr Phosphorylation Regulates the Fatty Acyl-AMP Ligase Activity of FadD32, an Essential Enzyme in Mycolic Acid Biosynthesis.
Lire plus20 janv. 2016
20 janv. 2016
02 déc. 2015
16 juil. 2015
03 juil. 2015
03 juil. 2015
18 juin 2015
publication
Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.
Lire plus11 mai 2015
25 mars 2015
publication
The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation.
Lire plus17 nov. 2014
publication
Secondary structure reshuffling modulates glycosyltransferase function at the membrane.
Lire plus24 sept. 2014
publication
Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c.
Lire plus01 févr. 2014
publication
A dual conformation of the post-decarboxylation intermediate is associated with distinct enzyme states in mycobacterial KGD (α-ketoglutarate decarboxylase).
Lire plus08 sept. 2013
11 janv. 2013
publication
Tolerance of the archaeal Sac7d scaffold protein to alternative library designs: characterization of anti-immunoglobulin G Affitins.
Lire plus10 janv. 2013
publication
Contactin 4, -5 and -6 differentially regulate neuritogenesis while they display identical PTPRG binding sites.
Lire plus03 mai 2012
publication
Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.
Lire plus26 août 2011
publication
Functional plasticity and allosteric regulation of α-ketoglutarate decarboxylase in central mycobacterial metabolism.
Lire plus01 juin 2011
publication
3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation.
Lire plus01 sept. 2010
publication
Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance.
Lire plus13 avr. 2010
15 févr. 2010
publication
Crystal structure of Mycobacterium tuberculosis LppA, a lipoprotein confined to pathogenic mycobacteria.
Lire plus09 oct. 2009
publication
Structural plasticity and distinct drug-binding modes of LfrR, a mycobacterial efflux pump regulator.
Lire plus18 sept. 2009
publication
Structure of Mycobacterium tuberculosis Rv2714, a representative of a duplicated gene family in Actinobacteria.
Lire plus15 avr. 2009
17 oct. 2008
02 oct. 2007
publication
Structural and binding studies of the three-metal center in two mycobacterial PPM Ser/Thr protein phosphatases.
Lire plus14 août 2007
publication
Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential.
Lire plus01 juil. 2007
publication
Insights into the catalytic mechanism of PPM Ser/Thr phosphatases from the atomic resolution structures of a mycobacterial enzyme.
Lire plus02 mai 2006
publication
The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.
Lire plus27 avr. 2006
publication
The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria.
Lire plus01 août 2005
publication
Conserved autophosphorylation pattern in activation loops and juxtamembrane regions of Mycobacterium tuberculosis Ser/Thr protein kinases.
Lire plus01 mars 2005
publication
Glutamine amidotransferase activity of NAD+ synthetase from Mycobacterium tuberculosis depends on an amino-terminal nitrilase domain.
Lire plus01 août 2004
publication
Rv2686c-Rv2687c-Rv2688c, an ABC fluoroquinolone efflux pump in Mycobacterium tuberculosis.
Lire plus01 août 2003
publication
Techniques and applications: The heterologous expression of Mycobacterium tuberculosis genes is an uphill road.
Lire plus01 janv. 2003
publication
The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology
Lire plus01 nov. 2002
publication
The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis.
Lire plus01 oct. 2002
publication
Reconstitution of T-cell receptor repertoire diversity following non-myeloablative allogeneic stem cell transplantation in an acute myeloid leukemia patient.
Lire plus01 sept. 2002
publication
High prevalence of a variant of SENV in intravenous drug user HIV-infected patients.
Lire plus01 août 2002
publication
Heterologous expression, purification, and enzymatic activity of Mycobacterium tuberculosis NAD(+) synthetase.
Lire plus01 mars 2002