Timeline

Marco Bellinzoni
Permanent Researcher
30 Jul 2024
publication
Corynebacterium glutamicum pyruvate:quinone oxidoreductase: an enigmatic metabolic enzyme with unusual structural features
Read more10 Aug 2023
publication
High resolution cryo-EM and crystallographic snapshots of the actinobacterial two-in-one 2-oxoglutarate dehydrogenase.
Read more25 Sep 2022
publication
Structural Basis for the Binding of Allosteric Activators Leucine and ADP to Mammalian Glutamate Dehydrogenase.
Read more22 Jun 2022
event
PhD Thesis :“ Integrative structural biology of a mixed PDH/ODH supercomplex from Corynebacterium glutamicum ”
Read more30 Nov 2021
publication
Actinobacteria challenge the paradigm: A unique protein architecture for a well-known, central metabolic complex.
Read more26 Oct 2021
publication
A Tetratricopeptide Repeat Scaffold Couples Signal Detection to OdhI Phosphorylation in Metabolic Control by the Protein Kinase PknG.
Read more30 Jul 2021
publication
Proteome remodeling in the Mycobacterium tuberculosis PknG knockout: Molecular evidence for the role of this kinase in cell envelope biogenesis and hypoxia response.
Read more09 Jul 2020
publication
Shedding X-ray Light on the Role of Magnesium in the Activity of Mycobacterium tuberculosis Salicylate Synthase (MbtI) for Drug Design.
Read more20 Jun 2020
01 Jan 2020
publication
Selective Inhibition of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases by the Phosphonate Analogs of Their 2-Oxo Acid Substrates.
Read more01 Dec 2019
publication
New insight into structure-activity of furan-based salicylate synthase (MbtI) inhibitors as potential antitubercular agents.
Read more01 Nov 2019
publication
Conformational transitions in the active site of mycobacterial 2-oxoglutarate dehydrogenase upon binding phosphonate analogues of 2-oxoglutarate: From a Michaelis-like complex to ThDP adducts.
Read more26 Jun 2019
publication
Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases.
Read more16 May 2019
07 May 2019
publication
Structural insights into the functional versatility of an FHA domain protein in mycobacterial signaling.
Read more01 May 2019
publication
Novel mechanistic insights into physiological signaling pathways mediated by mycobacterial Ser/Thr protein kinases.
Read more10 Feb 2019
publication
New substrates and interactors of the mycobacterial Serine/Threonine protein kinase PknG identified by a tailored interactomic approach.
Read more16 Nov 2017
event
Prof. Michael BOTT – “Corynebacterium glutamicum – microbial cell factory and model organism for actinobacteria”
Read more17 May 2017
publication
PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis.
Read more29 Jan 2017
publication
The crystal structure of PknI from Mycobacterium tuberculosis shows an inactive, pseudokinase-like conformation.
Read more01 Sep 2016
publication
Ser/Thr Phosphorylation Regulates the Fatty Acyl-AMP Ligase Activity of FadD32, an Essential Enzyme in Mycolic Acid Biosynthesis.
Read more20 Jan 2016
20 Jan 2016
02 Dec 2015
16 Jul 2015
03 Jul 2015
03 Jul 2015
18 Jun 2015
publication
Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG.
Read more11 May 2015
25 Mar 2015
publication
The crystal structure of the catalytic domain of the ser/thr kinase PknA from M. tuberculosis shows an Src-like autoinhibited conformation.
Read more17 Nov 2014
publication
Secondary structure reshuffling modulates glycosyltransferase function at the membrane.
Read more24 Sep 2014
publication
Structural studies suggest a peptidoglycan hydrolase function for the Mycobacterium tuberculosis Tat-secreted protein Rv2525c.
Read more01 Feb 2014
publication
A dual conformation of the post-decarboxylation intermediate is associated with distinct enzyme states in mycobacterial KGD (α-ketoglutarate decarboxylase).
Read more08 Sep 2013
11 Jan 2013
publication
Tolerance of the archaeal Sac7d scaffold protein to alternative library designs: characterization of anti-immunoglobulin G Affitins.
Read more10 Jan 2013
publication
Contactin 4, -5 and -6 differentially regulate neuritogenesis while they display identical PTPRG binding sites.
Read more03 May 2012
publication
Conformational changes upon ligand binding in the essential class II fumarase Rv1098c from Mycobacterium tuberculosis.
Read more26 Aug 2011
publication
Functional plasticity and allosteric regulation of α-ketoglutarate decarboxylase in central mycobacterial metabolism.
Read more01 Jun 2011
publication
3-Keto-5-aminohexanoate cleavage enzyme: a common fold for an uncommon Claisen-type condensation.
Read more01 Sep 2010
publication
Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance.
Read more13 Apr 2010
15 Feb 2010
publication
Crystal structure of Mycobacterium tuberculosis LppA, a lipoprotein confined to pathogenic mycobacteria.
Read more09 Oct 2009
publication
Structural plasticity and distinct drug-binding modes of LfrR, a mycobacterial efflux pump regulator.
Read more18 Sep 2009
publication
Structure of Mycobacterium tuberculosis Rv2714, a representative of a duplicated gene family in Actinobacteria.
Read more15 Apr 2009
17 Oct 2008
02 Oct 2007
publication
Structural and binding studies of the three-metal center in two mycobacterial PPM Ser/Thr protein phosphatases.
Read more14 Aug 2007
publication
Mycobacterial Ser/Thr protein kinases and phosphatases: physiological roles and therapeutic potential.
Read more01 Jul 2007
publication
Insights into the catalytic mechanism of PPM Ser/Thr phosphatases from the atomic resolution structures of a mycobacterial enzyme.
Read more02 May 2006
publication
The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.
Read more27 Apr 2006
publication
The structure of PknB in complex with mitoxantrone, an ATP-competitive inhibitor, suggests a mode of protein kinase regulation in mycobacteria.
Read more01 Aug 2005
publication
Conserved autophosphorylation pattern in activation loops and juxtamembrane regions of Mycobacterium tuberculosis Ser/Thr protein kinases.
Read more01 Mar 2005
publication
Glutamine amidotransferase activity of NAD+ synthetase from Mycobacterium tuberculosis depends on an amino-terminal nitrilase domain.
Read more01 Aug 2004
publication
Rv2686c-Rv2687c-Rv2688c, an ABC fluoroquinolone efflux pump in Mycobacterium tuberculosis.
Read more01 Aug 2003
publication
Techniques and applications: The heterologous expression of Mycobacterium tuberculosis genes is an uphill road.
Read more01 Jan 2003
publication
The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology
Read more01 Nov 2002
publication
The multidrug transporters belonging to major facilitator superfamily in Mycobacterium tuberculosis.
Read more01 Oct 2002
publication
Reconstitution of T-cell receptor repertoire diversity following non-myeloablative allogeneic stem cell transplantation in an acute myeloid leukemia patient.
Read more01 Sep 2002
publication
High prevalence of a variant of SENV in intravenous drug user HIV-infected patients.
Read more01 Aug 2002
publication
Heterologous expression, purification, and enzymatic activity of Mycobacterium tuberculosis NAD(+) synthetase.
Read more01 Mar 2002