Signalisation antivirale

Tick-borne encephalitis virus (TBEV) is a growing health concern in Europe and Asia. It causes severe disease that can lead to permanent neurological complications or death. Recently, the incidence of TBEV infections in endemic […]

Knowledge concerning the interaction of SARS-CoV-2 with human and bat cells is sparse. We will use state-of-the-art RNA-sequencing analysis, original bioinformatics tools, loss-of-function approaches and mechanistic studies to identify and characterize coding and non-coding […]

Our project proposes to address, in vitro and in cells infected with Flaviviruses and Coronaviruses, the mechanisms by which enzymes forming the replication transcription complexes i) replicate and transcribe faithfully the RNA genome, ii) […]

The interferon (IFN) response protects cells from invading viral pathogens by transcriptionally inducing the expression of interferon-stimulated genes (ISGs). Only a handful of these ISGs have been well characterized, mainly by artificial gain-of-function screening […]

Collaborative project with UMR Virologie (INRA, ANSES, ENVA), Maisons-Alfort, France. Flaviviruses, which are principally transmitted by mosquitoes and ticks, cause devastating human diseases such as Dengue fever in the tropics and subtropics and are […]

Several enveloped RNA viruses of the Arenaviridae, Bunyaviridae, Filoviridae and Flaviviridae families are associated with a syndrome known as viral hemorrhagic fever (VHF). VHF is characterized by fever, vascular leakage, coagulation defects and multi-organ […]

Vaccination is one of the greatest successes of modern medicine. The first generation of viral vaccines relied on empiric attenuation by repeated passage in animals and/or cultured cells. A successful attenuation process eliminates virulence […]