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We are developing new computational methods to calculate the electrostatics of proteins, understand their dynamical properties and simulate transitions between two known conformations of the same macromolecule.
We work with archaeal DNA polymerases to make them accept xeno-nucleotides and synthesize variants of DNA and RNA in vivo.
We study the mechanism of DNA Repair of (DNA) Double Strand Breaks through the so-called Non-Homologous End Joining (NHEJ) process in mammals using x-ray crystallography and structural studies of pol mu and Tdt
We have developed a new way to calculate electrostatics properties of biological macromolecules in a polarizable solvent: AquaSol. We can then compute the solvent density around proteins as well as their SAXS spectra: AquaSAXS.
Marie de Tarragon Phone: Ext. 39 45 Email: firstname.lastname@example.org Unite de Dynamique Structurales des Macromolecules Biologiques 25-28 Rue du Docteur Roux 75015, Paris France