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Responsable de Structure
Development of methods in computational structural biology
We are developing new computational methods to calculate the electrostatics of proteins, understand their dynamical properties and simulate transitions between two known conformations of the same macromolecule.
DNA Replication and Synthetic Biology
We work with archaeal DNA polymerases to make them accept xeno-nucleotides and synthesize variants of DNA and RNA in vivo.
DNA Repair and Cancer
We study the mechanism of DNA Repair of (DNA) Double Strand Breaks through the so-called Non-Homologous End Joining (NHEJ) process in mammals using x-ray crystallography and structural studies of pol mu and Tdt
We have developed a new way to calculate electrostatics properties of biological macromolecules in a polarizable solvent: AquaSol. We can then compute the solvent density around proteins as well as their SAXS spectra: AquaSAXS.
2015Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair - The EMBO journal
2015Genuine open form of the pentameric ligand-gated ion channel GLIC - Acta crystallographica. Section D, Biological crystallography
2015Allosteric and hyperekplexic mutant phenotypes investigated on an α1 glycine receptor transmembrane structure - Proceedings of the National Academy of Sciences of the United States of America
2014Crystallographic studies of pharmacological sites in pentameric ligand-gated ion channels - Biochimica et biophysica acta
2013Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation - Proceedings of the National Academy of Sciences of the United States of America
2013Structures of intermediates along the catalytic cycle of terminal deoxynucleotidyltransferase: dynamical aspects of the two-metal ion mechanism - Journal of molecular biology
2013Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels - The EMBO journal
2013Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel - Nature communications
2012Molecular recognition of canonical and deaminated bases by P. abyssi family B DNA polymerase - Journal of molecular biology
2012Structure and pharmacology of pentameric receptor channels: from bacteria to brain - Structure (London, England : 1993)
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Unite de Dynamique Structurales des Macromolecules Biologiques
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