Pour plus d’informations sur la plateforme, voir la page web en anglais :
https://research.pasteur.fr/en/team/fabrice-agou-team/
(19/01/2018)
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Connexions
Équipements
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Array
Echo Liquid Handler System • Labcyte • Echo 550
The Echo 550 instrument enables non-contact liquid handling using sound energy, high speed, contamination-free transfer of cDNA, siRNA vectors, proteins and crystallography reagents – in nanoliter increments. Echo Plate Reformat software offers a variety […]
Octet Instrument • ForteBio • Octet HTX System
The Octet HTX instrument monitors up to 96 biosensors simultaneously, enabling label-free detection for protein quantitation and kinetic characterization at unmatched speed. The system’s ability to read 8, 16, 32, 48 or 96 wells […]
Microscope • Olympus • IX83
The fully motorized IX83 is the most advanced member of the IX3 series of inverted imaging systems and offers a new level of application flexibility. Choose from the one-deck system with a low, ergonomic […]
Microscope • Optical Biosystems • StellarVision
Target-based, cell-based and phenotypic/microscopy screening assay have numerous advantages and disadvantages and an important challenge in the near future will be to effectively incorporate new screening technologies into phenotypic screening approaches since the traditional […]
Plate Reader • Wyatt Technology • DynaPro Plate Reader II
For small molecules, the DynaPro Plate Reader II can easily detect compound aggregates and aggregation inducers which often result from High-Throughput Screening (HTS) campaign. These primary Hits are often considered as false-positives with poor […]
Membres
Fabrice Agou
Responsable de Plateforme
Responsable
Groupes
Group
Groupe: Biochimie et chémobiologie
Hélène Munier-Lehmann
Anciens Membres
2000
2000
Name
Position
2015
2020
Laurianne Davignon
Post-doc
2015
2020
Elisabeth Fontan
2015
2020
Keïs Nabhane Said Halidi
2015
2020
Sara Consalvi
Post-doc
2015
2020
Marine Charpentier
Post-doc
2015
2020
Emmanuel Laplantine
Group Leader
2016
2021
Christine Detcheparre
Administrative Staff (retired)
(EN) 2020
(EN) 2022
(EN) Anne Huard de Verneuil
(EN) Engineer
Projet Transversal
Financements
Principales publications
Anca F. Savulescu, Robyn Brackin, Emmanuel Bouilhol, Benjamin Dartigues, Jonathan H. Warrell, Mafalda R. Pimentel, Nicolas Beaume, Isabela C. Fortunato, Stephane Dallongeville, Mikaël Boullé, Hayssam Soueidan, Fabrice Agou, Jan Schmoranzer, Jean-Christophe Olivo-Marin, Claudio A. Franco, Edgar R. Gomes, Macha Nikolski, Musa M. Mhlanga. “Interrogating RNA and protein spatial subcellular distribution in smFISH data with DypFISH“.
doi: 10.1016/j.crmeth.2021.100068. In press. PubMed PMID: to be communicated.
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2022Potent human broadly SARS-CoV-2-neutralizing IgA and IgG antibodies effective against Omicron BA.1 and BA.2, J Exp Med . 2022 Jul 4;219(7):e20220638. doi: 10.1084/jem.20220638. Epub 2022 Jun 15. .
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2022A novel screening strategy to identify histone methyltransferase inhibitors reveals a crosstalk between DOT1L and CARM1†, DOI: 10.1039/D1CB00095K (Paper) RSC Chem. Biol., 2022, 3, 456-467.
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2021Interrogating RNA and protein spatial subcellular distribution in smFISH data with DypFISH, Volume 1, Issue 5, 27 September 2021, 100068.
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2021Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential., Nat Commun 2021 09; 12(1): 5553.
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2021SARS-CoV-2 variant prediction and antiviral drug design are enabled by RBD in vitro evolution., Nat Microbiol 2021 09; 6(9): 1188-1198.
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2021SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction., Nucleic Acids Res 2021 Jul; (): .
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2021Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues., Nat Commun 2021 05; 12(1): 3100.
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2021Inhibition of the replication of SARS-CoV-2 in human cells by the FDA-approved drug chlorpromazine., Int J Antimicrob Agents 2021 Mar; 57(3): 106274.
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+Voir la liste complète de publications
Contact
Phone: +33 (0)1 40 61 38 10 Email: pfccb@pasteur.fr Address 25-28 Rue du Docteur Roux 75015, Paris France