Plateforme de Criblage Chémogénomique et Biologique (PF-CCB)

Présentation

Pour plus d’informations sur la plateforme, voir la page web en anglais :
https://research.pasteur.fr/en/team/fabrice-agou-team/
(19/01/2018)

Membres

Fabrice Agou

Responsable de Plateforme

Responsable

Alix Boucharlat

Ingénieur(e) de Recherche

Agnès Zettor

Technicien(ne)

Christine Detchepare

Personnel Administratif

Mikaël Boullé

Etudiant(e) en thèse

Anciens Membres

Laurianne Davignon

Elisabeth Fontan

Keïs Nabhane Said Halidi

Sara Consalvi

Marine Charpentier

Emmanuel Laplantine

Projet Transversal

Lutter contre la résistance aux antibiotiques

Les antibiotiques éliminent de manière efficace les bactéries pathogènes avec le plus souvent peu d’effets indésirables. Ces médicaments “miracles” ont eu depuis plus de 70 ans un impact majeur pour améliorer la santé humaine […]

Institut Carnot Pasteur MS

Le label Carnot vise à reconnaître la 
capacité de structures de recherche à collaborer avec des partenaires socio-
économiques, notamment des entreprises, tout en renforçant leur visibilité. Un institut Canot (IC) labélisé bénéficie de moyens […]

Équipements

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Array

Echo Liquid Handler System • Labcyte • Echo 550

The Echo 550 instrument enables non-contact liquid handling using sound energy, high speed, contamination-free transfer of cDNA, siRNA vectors, proteins and crystallography reagents – in nanoliter increments. Echo Plate Reformat software offers a variety […]

Octet Instrument • ForteBio • Octet HTX System

The Octet HTX instrument monitors up to 96 biosensors simultaneously, enabling label-free detection for protein quantitation and kinetic characterization at unmatched speed. The system’s ability to read 8, 16, 32, 48 or 96 wells […]

Microscope • Olympus • IX83

The fully motorized IX83 is the most advanced member of the IX3 series of inverted imaging systems and offers a new level of application flexibility. Choose from the one-deck system with a low, ergonomic […]

Microscope • Optical Biosystems • StellarVision

Target-based, cell-based and phenotypic/microscopy screening assay have numerous advantages and disadvantages and an important challenge in the near future will be to effectively incorporate new screening technologies into phenotypic screening approaches since the traditional […]

Plate Reader • Wyatt Technology • DynaPro Plate Reader II

For small molecules, the DynaPro Plate Reader II can easily detect compound aggregates and aggregation inducers which often result from High-Throughput Screening (HTS) campaign. These primary Hits are often considered as false-positives with poor […]

Financements

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Publications

Télécharger

• 2018
  Charpentier M, Khedher AHY, Menoret S, Brion A, Lamribet K, Dardillac E, Boix C, Perrouault L, Tesson L, Geny S, De Cian A, Itier JM, Anegon I, Lopez B, Giovannangeli C and Concordet JP, CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair., Nat Commun. 2018 Mar 19;9(1):1133.
• 2018
  Vincenzo Di Donato, Flavia De Santis, Shahad Albadri, Thomas Oliver Auer, Karine Duroure, Marine Charpentier, Jean-Paul Concordet, Christoph Gebhardt, and Filippo Del Bene, An Attractive Reelin Gradient Establishes Synaptic Lamination in the Vertebrate Visual System, Neuron. 2018 Feb 5. pii: S0896-6273(18)30055-2..
• 2018
  Valentine Mosbach, Lucie Poggi, David Viterbo, Marine Charpentier and Guy-Franck Richard, TALEN-Induced Double-Strand Break Repair of CTG Trinucleotide Repeats., Cell Rep. 2018 Feb 20;22(8):2146-2159.
• 2017
  Eckenfelder A, Ségéral E, Pinzón N, Ulveling D, Amadori C, Charpentier M, Nidelet S, Concordet JP, Zagury JF, Paillart JC, Berlioz-Torrent C, Seitz H, Emiliani S, Gallois-Montbrun S, Argonaute proteins regulate HIV-1 multiply spliced RNA and viral production in a Dicer independent manner, Nucleic Acids Res. 2017 Apr;45(7):4158-4173.
• 2017
  Bal E, Laplantine E, Hamel Y, Dubosclard V, Boisson B, Pescatore A, Picard C, Hadj-Rabia S, Royer G, Steffann J, Bonnefont JP, Ursini VM, Vabres P, Munnich A, Casanova JL, Bodemer C, Weil R, Agou F, Smahi A, Lack of interaction between NEMO and SHARPIN impairs linear ubiquitination and NF-κB activation and leads to incontinentia pigmenti., J Allergy Clin Immunol. 2017 Dec;140(6):1671-1682.e2.
• 2017
  Mahamed D, Boulle M, Ganga Y, Mc Arthur C, Skroch S, Oom L, Catinas O, Pillay K, Naicker M, Rampersad S, Mathonsi C, Hunter J, Wong EB, Suleman M, Sreejit G, Pym AS, Lustig G, Sigal A, Intracellular growth of Mycobacterium tuberculosis after macrophage cell death leads to serial killing of host cells., Elife. 2017 May 5;6. pii: e28205.
• 2017
  Phillips AF, Millet AR, Tigano M, Dubois SM, Crimmins H, Babin L, Charpentier M, Piganeau M, Brunet E, Sfeir A, Single-Molecule Analysis of mtDNA Replication Uncovers the Basis of the Common Deletion, Mol. Cell 2017 Feb;65(3):527-538.e6.
• 2016
  Boullé M, Müller TG, Dähling S, Ganga Y, Jackson L, Mahamed D, Oom L, Lustig G, Neher RA, Sigal A, HIV Cell-to-Cell Spread Results in Earlier Onset of Viral Gene Expression by Multiple Infections per Cell, PLoS Pathog. 2016 Nov 3;12(11):e1005964.
• 2016
  Scholefield J, Henriques R, Savulescu AF, Fontan E, Boucharlat A, Laplantine E, Smahi A, Israël A, Agou F* and Mhlanga MM*., Super-resolution microscopy reveals a preformed NEMO lattice structure that is collapsed in incontinentia pigmenti, Nat Commun. 2016 Sep 2;7:12629.
• 2016
  Gammage PA, Gaude E, Van Haute L, Rebelo-Guiomar P, Jackson CB, Rorbach J, Pekalski ML, Robinson AJ, Charpentier M, Concordet JP, Frezza C, Minczuk M, Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs, Nucleic Acids Res. 2016 Sep;44(16):7804-16.
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  Voir la liste complète de publications

Contact

Phone: +33 (0)1 40 61 38 10
Email: pfccb@pasteur.fr

Address
25-28 Rue du Docteur Roux
75015, Paris
France

Publié le: 05 Jun 2015 • Modifié le: 23 Aug 2019