Inhibitors of bacterial NAD kinases
NAD mimics as potential antibacterial agents The NAD(P) biosynthesis pathways have attracted recent interest as a source of enzyme targets for the development of antimicrobial agents. Our own research focused on the structure-based development […]
Protein synthesis machinery of Trypanosomatid as a therapeutic target
Pathogenic protozoans of the trypanosomatid group still remain a major world health problem. Cycling between insect vectors and mammalian hosts, Trypanosoma cruzi is the causative agent of Chagas disease, while over 20 Leishmania species […]
Inhibitors of the 2’-deoxyribonucleotide N-hydrolase DNPH1, an enzyme involved in cellular growth and angiogenesis
Nucleoside analogues as potential antitumor agents. This project aims to characterize and validate the nucleotide N-hydrolase DNPH1 as a new target in oncology. Inhibition of Rcl alone or in combination with other chemotherapeutic drugs […]
Inhibitors of Pseudomonas aeruginosa IMPDH
IMPDH from Pseudomonas aeruginosa (see Inosine-5′-monophosphate dehydrogenase project) was found to be allosterically regulated by MgATP (Labesse et al., 2013). The discovery of this mode of regulation of the catalytic activity, never described before […]
Inhibitors of TMPK from Mycobacterium tuberculosis
TMPK from Mycobacterium tuberculosis belongs to the NMPK family, which was chosen as potential targets for the development of new antimicrobials (see “Nucleoside monophosphate kinases” project). Based on the 3D-structure of TMPK from M. […]
2020High seroprevalence but short-lived immune response to SARS-CoV-2 infection in Paris., Eur J Immunol 2020 Dec; (): .
2020Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents., Eur J Med Chem 2020 Nov; 206(): 112659.
2020Core-modified coelenterazine luciferin analogues, synthesis and chemiluminescence properties., Chemistry 2020 Nov; (): .
2020Identification of antiviral compounds against equid herpesvirus-1 using real-time cell assay screening: efficacy of decitabine and valganciclovir alone or in combination., Antiviral Res. 2020 Sep; (): 104931.
2020Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents., Eur J Med Chem 2020 Sep; 201(): 112450.
2020Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors., Sci Rep 2020 Jun; 10(1): 10100.
20201-(1-Arylethylpiperidin-4-yl)thymine Analogs as Antimycobacterial TMPK Inhibitors., Molecules 2020 Jun; 25(12): .
2020A real-time cell-binding assay reveals dynamic features of STxB-Gb3 cointernalization and STxB-mediated cargo delivery into cancer cells., FEBS Lett. 2020 May; (): .
2020A highly sensitive bioluminescent method for measuring allergen-specific IgE in microliter samples., Allergy 2020 May; (): .
2020Fermentation Products of Commensal Bacteria Alter Enterocyte Lipid Metabolism, Cell Host Microbe 2020 March 11;27:1-18.
+Voir la liste complète de publications
Phone: 33/1 40 61 38 05 Email: firstname.lastname@example.org Address 25-28 Rue du Docteur Roux 75015, Paris France