-
2023Host-pathogen interactions from a metabolic perspective: methods of investigation., Microbes Infect 2023 Nov; (): 105267.
-
2023From Bacterial Toxin to Therapeutic Agent: The Unexpected Fate of Mycolactone., Toxins (Basel) 2023 May; 15(6): .
-
2023Nutrient-dependent regulation of β-cell proinsulin content., J Biol Chem 2023 May; (): 104836.
-
2023Defensive-lipid droplets: Cellular organelles designed for antimicrobial immunity., Immunol Rev 2023 Mar; (): .
-
2023Click-chemistry-based protocol to quantitatively assess fatty acid uptake by Mycobacterium tuberculosis in axenic culture and inside mouse macrophages., STAR Protoc 2023 Jan; 4(1): 102062.
-
2023Sec61 blockade therapy overrides resistance to proteasome inhibitors and immunomodulatory drugs in multiple myeloma., Front Oncol 2023 ; 13(): 1110916.
-
2022The Sec61 translocon is a therapeutic vulnerability in multiple myeloma., EMBO Mol Med 2022 03; 14(3): e14740.
-
2022Mycolactone Purification from M. ulcerans Cultures and HPLC-Based Approaches for Mycolactone Quantification in Biological Samples., Methods Mol Biol 2022 ; 2387(): 117-130.
-
2022Biochemical and Biological Assays of Mycolactone-Mediated Inhibition of Sec61., Methods Mol Biol 2022 ; 2387(): 163-181.
-
2021De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis., Elife 2021 Dec; 10(): .
-
2021Insights into the ancestry evolution of the Mycobacterium tuberculosis complex from analysis of Mycobacterium riyadhense., NAR Genom Bioinform 2021 Sep; 3(3): lqab070.
-
2021Immunity against Mycobacterium ulcerans: The subversive role of mycolactone., Immunol Rev 2021 Feb; (): .
-
2021Not too fat to fight: The emerging role of macrophage fatty acid metabolism in immunity to Mycobacterium tuberculosis., Immunol Rev 2021 Feb; (): .
-
2021Molecular Mechanisms Underpinning the Circulation and Cellular Uptake of Mycobacterium ulcerans Toxin Mycolactone., Front Pharmacol 2021 ; 12(): 733496.
-
2021Host Immune-Metabolic Adaptations Upon Mycobacterial Infections and Associated Co-Morbidities., Front Immunol 2021 ; 12(): 747387.
-
2020Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system., Nat Commun 2020 12; 11(1): 6363.
-
2020Spatiotemporal analysis of mycolactone distribution in vivo reveals partial diffusion in the central nervous system., PLoS Negl Trop Dis 2020 Dec; 14(12): e0008878.
-
2020Autoantibodies against type I IFNs in patients with life-threatening COVID-19., Science 2020 Oct; 370(6515): .
-
2020Repair of G1 induced DNA double-strand breaks in S-G2/M by alternative NHEJ., Nat Commun 2020 Oct; 11(1): 5239.
-
2020Mycolactone induces cell death by SETD1B-dependent degradation of glutathione., 2020 Oct; 14(10): e0008709.
-
2020Dysregulation of tryptophan catabolism at the host-skin microbiota interface in Hidradenitis Suppurativa., 2020 Sep 24;140598..
-
2019CR3 Engaged by PGL-I Triggers Syk-Calcineurin-NFATc to Rewire the Innate Immune Response in Leprosy, Front Immunol 2019;10:2913.
-
2019A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals., Microbiome 2019 Sep; 7(1): 130.
-
2019Recombinant Antibodies against Mycolactone, Toxins (Basel) 2019 Jun;11(6).
-
2019Ipomoeassin F Binds Sec61α to Inhibit Protein Translocation, J. Am. Chem. Soc. 2019 May;.
-
2018Sec61 blockade by mycolactone: A central mechanism in Buruli ulcer disease, Biol. Cell 2018 Jul;.
-
2018Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines., Genome Med 2018 Jul; 10(1): 59.
-
2018Proteomics reveals scope of mycolactone-mediated Sec61 blockade and distinctive stress signature, Mol. Cell Proteomics 2018 Jun;.
-
2017Mycolactone displays anti-inflammatory effects on the nervous system, PLoS Negl Trop Dis 2017 Nov;11(11):e0006058.
-
2017Modular total syntheses of mycolactone A/B and its [(2)H]-isotopologue, Org. Biomol. Chem. 2017 Sep;15(36):7518-7522.
-
2017Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export, Proc. Natl. Acad. Sci. U.S.A. 2017 Jul;114(29):E5910-E5919.
-
2017Zika virus induces massive cytoplasmic vacuolization and paraptosis-like death in infected cells., EMBO J. 2017 06; 36(12): 1653-1668.
-
2017Pathogenic and immunosuppressive properties of mycobacterial phenolic glycolipids, Biochimie 2017 Mar;.
-
2016Mycolactone subverts immunity by selectively blocking the Sec61 translocon., J Exp Med 2016 12; 213(13): 2885-2896.
-
2016Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses., Cell Rep 2016 Sep; 16(10): 2777-2791.
-
2015Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease., Sci Rep 2015 Dec; 5(): 17693.
-
2015Shaping mycolactone for therapeutic use against inflammatory disorders., Sci Transl Med 2015 May; 7(289): 289ra85.
-
2014Synthetic variants of mycolactone bind and activate Wiskott-Aldrich syndrome proteins, J. Med. Chem. 2014 Sep;57(17):7382-95.
-
2014Adhesion of the ulcerative pathogen Mycobacterium ulcerans to DACC-coated dressings, J Wound Care 2014 Aug;23(8):417-8, 422-4.
-
2014Combined inflammatory and metabolic defects reflected by reduced serum protein levels in patients with Buruli ulcer disease., PLoS Negl Trop Dis 2014 Apr; 8(4): e2786.
-
2014Pathogenesis of skin ulcers: lessons from the Mycobacterium ulcerans and Leishmania spp. pathogens, Cell. Mol. Life Sci. 2014 Jul;71(13):2443-50.
-
2013Proteomic analysis of the SH2 domain-containing leukocyte protein of 76 kDa (SLP76) interactome in resting and activated primary mast cells [corrected], Mol. Cell Proteomics 2013 Oct;12(10):2874-89.
-
2013Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation, J. Clin. Invest. 2013 Apr;123(4):1501-12.
-
2012Preexisting BCG-specific T cells improve intravesical immunotherapy for bladder cancer, Sci Transl Med 2012 Jun;4(137):137ra72.
-
2012ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria, Cell. Microbiol. 2012 Aug;14(8):1287-98.
-
2011A diverted total synthesis of mycolactone analogues: an insight into Buruli ulcer toxins, Chemistry 2011 Dec;17(51):14413-9.
-
2011Mycolactone diffuses into the peripheral blood of Buruli ulcer patients–implications for diagnosis and disease monitoring, PLoS Negl Trop Dis 2011 Jul;5(7):e1237.
-
2011Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression., Proc. Natl. Acad. Sci. U.S.A. 2011 Aug; 108(31): 12833-8.
-
2010Mycobacterium leprae phenolglycolipid-1 expressed by engineered M. bovis BCG modulates early interaction with human phagocytes, PLoS Pathog. 2010;6(10):e1001159.
-
2009Immunosuppressive signature of cutaneous Mycobacterium ulcerans infection in the peripheral blood of patients with buruli ulcer disease, J. Infect. Dis. 2009 Dec;200(11):1675-84.
-
2009Lipids of pathogenic Mycobacteria: contributions to virulence and host immune suppression, Transbound Emerg Dis 2009 Aug;56(6-7):255-68.
-
2009Buruli ulcer disease: prospects for a vaccine, Med. Microbiol. Immunol. 2009 May;198(2):69-77.
-
2009Buruli ulcer: reductive evolution enhances pathogenicity of Mycobacterium ulcerans, Nat. Rev. Microbiol. 2009 Jan;7(1):50-60.
-
2008Mycolactone diffuses from Mycobacterium ulcerans-infected tissues and targets mononuclear cells in peripheral blood and lymphoid organs, PLoS Negl Trop Dis 2008;2(10):e325.
-
2008Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteria, Nat Prod Rep 2008 Jun;25(3):447-54.
-
2007A novel mycolactone toxin obtained by biosynthetic engineering, Chembiochem 2007 Nov;8(17):2043-7.
-
2007Selective suppression of dendritic cell functions by Mycobacterium ulcerans toxin mycolactone, J. Exp. Med. 2007 Jun;204(6):1395-403.
-
2006Inactivation of Rv2525c, a substrate of the twin arginine translocation (Tat) system of Mycobacterium tuberculosis, increases beta-lactam susceptibility and virulence, J. Bacteriol. 2006 Sep;188(18):6669-79.
-
2006Towards an immunodiagnostic test for leprosy, Microbes Infect. 2006 Jul;8(8):2270-6.
-
2006Immunogenicity of Mycobacterium ulcerans Hsp65 and protective efficacy of a Mycobacterium leprae Hsp65-based DNA vaccine against Buruli ulcer, Microbes Infect. 2006 Jul;8(8):2075-81.
-
2006Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence, Infect. Immun. 2006 Jan;74(1):88-98.
-
2006Antigen discovery: a postgenomic approach to leprosy diagnosis, Infect. Immun. 2006 Jan;74(1):175-82.
-
2005Tuberculosis: from genome to vaccine, Expert Rev Vaccines 2005 Aug;4(4):541-51.
-
2005Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin, Cell. Microbiol. 2005 Aug;7(8):1187-96.
-
2005Differential effects of prior exposure to environmental mycobacteria on vaccination with Mycobacterium bovis BCG or a recombinant BCG strain expressing RD1 antigens, Infect. Immun. 2005 Apr;73(4):2190-6.
-
2004Single chain antibody fragments for the selective targeting of antigens to dendritic cells, Mol. Immunol. 2005 May;42(8):979-85.
-
2004Targeting dendritic cells with antigen-containing liposomes: a highly effective procedure for induction of antitumor immunity and for tumor immunotherapy., Cancer Res 2004 Jun; 64(12): 4357-65.
-
2004Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6, Infect. Immun. 2004 Apr;72(4):2170-6.
-
2003Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis, Nat. Med. 2003 May;9(5):533-9.
-
2002TNF regulates chemokine induction essential for cell recruitment, granuloma formation, and clearance of mycobacterial infection, J. Immunol. 2002 May;168(9):4620-7.
-
2002Autocrine IL-10 impairs dendritic cell (DC)-derived immune responses to mycobacterial infection by suppressing DC trafficking to draining lymph nodes and local IL-12 production, Eur. J. Immunol. 2002 Apr;32(4):994-1002.
-
2001Mapping of a dengue virus neutralizing epitope critical for the infectivity of all serotypes: insight into the neutralization mechanism, J. Gen. Virol. 2001 Aug;82(Pt 8):1885-92.
-
2001Priming by DNA immunization augments protective efficacy of Mycobacterium bovis Bacille Calmette-Guerin against tuberculosis, Infect. Immun. 2001 Jun;69(6):4174-6.
-
2001Dendritic cells infected with Mycobacterium bovis bacillus Calmette Guerin activate CD8(+) T cells with specificity for a novel mycobacterial epitope, Int. Immunol. 2001 Apr;13(4):451-8.
-
2001Stimulation of dendritic cells via CD40 enhances immune responses to Mycobacterium tuberculosis infection, Infect. Immun. 2001 Apr;69(4):2456-61.
-
2000Interaction of dendritic cells with mycobacteria: where the action starts, Immunol. Cell Biol. 2000 Aug;78(4):318-24.
-
2000Identification of a peptide blocking vascular endothelial growth factor (VEGF)-mediated angiogenesis, EMBO J. 2000 Apr;19(7):1525-33.
-
2000Combining phage display and molecular modeling to map the epitope of a neutralizing antitoxin antibody, Eur. J. Biochem. 2000 Apr;267(8):2345-53.
-
1999Protection against aerosol Mycobacterium tuberculosis infection using Mycobacterium bovis Bacillus Calmette Guérin-infected dendritic cells, Eur. J. Immunol. 1999 Jun;29(6):1972-9.
-
1999Molecular mimicry between a monoclonal antibody and one subunit of crotoxin, a heterodimeric phospholipase A2 neurotoxin, Biol. Chem. 1999 May;380(5):561-8.
-
1998Phage-displayed mimotopes elicit monoclonal antibodies specific for a malaria vaccine candidate, Biol. Chem. 1998 Jan;379(1):65-70.
-
1997Phage-displayed and soluble mouse scFv fragments neutralize rabies virus, J. Virol. Methods 1997 Sep;67(2):221-33.
-
1997Biologically active human anti-crotoxin scFv isolated from a semi-synthetic phage library, Immunotechnology 1997 Jun;3(2):117-25.
-
1996Reproducing the immune response against the Plasmodium vivax merozoite surface protein 1 with mimotopes selected from a phage-displayed peptide library, Mol. Immunol. 1996 Aug;33(11-12):909-16.
-
1993An attempt to correlate cattle breed origins and diseases associated with or transmitted by the tick Amblyomma variegatum in the French West Indies, Rev Elev Med Vet Pays Trop 1993;46(1-2):283-90.
-
1992Lactate dehydrogenase (LDH) activity of the cultured eukaryotic cells as marker of the number of dead cells in the medium [corrected], J. Biotechnol. 1992 Sep;25(3):231-43.
-
1992Role of metabolic waste products in the control of cell proliferation and antibody production by mouse hybridoma cells, Hybridoma 1992 Jun;11(3):311-22.
-
1991Factors controlling cell proliferation and antibody production in mouse hybridoma cells: I. Influence of the amino acid supply, Biotechnol. Bioeng. 1991 Sep;38(6):561-70.
-
1990Comparison of various methods for monitoring hybridoma cell proliferation, J. Immunol. Methods 1990 Dec;134(2):177-85.