Florence Larrous

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Florence LARROUS, PhD, IP

EDUCATION

     2013                    PhD thesis, Microbiology, University Paris Diderot (Paris VII)

     1990                    BTS Biotechnology, ENCPB, Paris 13

RESEARCH and PRofessional EXPERIENCE

     2014- present       Research engineer in DyLah Unit,

     2000-2013           Technician in DyLah Unit (Pasteur Institut)

     1990-2000           Technician in Texcell (Pasteur Institut)

SCIENTIFIC ACTIVITIES

     19 publications, 1 international patent  – Hisch h index : 13

ADMINISTRATIVE RESPONSIBILITIES and EXPERTISE

– Technical competencies:

     Virology, cellular and molecular biology

     Reverse genetic on negative strand RNA virus

     Public health activities on rabies diagnosis

     Work according to quality assurance (AFNOR ISO17025 and ISO15189)

– Coaching competencies:

     Supervision of license or master students

     Participation in coaching of PhD students

     Technical manager for technician for rabies diagnosis activities

– Main research project:

     Study of molecular targets for the development of new antiviral strategies (replication complex of lyssaviruses).

     Role of the M and P proteins in the host-lyssavirus interplay

MOST SIGNIFICANT PUBLICATION IN THE LAST FIVE YEARS

• Ben Khalifa Y*, Luco S*, Besson B, Sonthonnax F, Archambaud M, Grimes JM, Larrous F Bourhy H; The matrix protein of rabies virus binds to RelAp43 to modulate NF-κB-dependent gene expression related to innate immunity. Sci Rep. 2016 Dec 21;6:39420.
• Dacheux L*., Larrous F.*, Lavenir R, Lepelletier A, Faouzi A, Troupin C, Nourlil J, Buchy P, Bourhy H ; Dual Combined Real-Time Reverse Transcriptase Polymerase Chain Reaction Assay for the Diagnosis of Lyssavirus Infection ; PLoS Negl Trop Dis. LoS Negl Trop Dis. 2016 Jul 5;10(7)
• de Thoisy B, Bourhy H, Delaval M, Pontier D, Dacheux L, Darcissac E, Donato D,Guidez A, Larrous F, Lavenir R, Salmier A, Lacoste V, Lavergne A. Bioecological ; Drivers of Rabies Virus Circulation in a Neotropical Bat Community. PLoS Negl Trop Dis. 2016 Jan 25;10(1).
• Contou D, Dacheux L, Bendib I, Jolivet S, Rodriguez C, Tomberli F, Cleret de Langavant L, Lavenir R, Lepelletier A, Larrous F, Troupin C, Bourhy H,Brun-Buisson C. Severe ketoalkalosis as initial presentation of imported human rabies in France. J Clin Microbiol. 2015 June;53(6):1979-82.
• Fouquet B, Nikolic J, Larrous F, Bourhy H, Wirblich C, Lagaudrière-Gesbert C, Blondel D. Focal adhesion kinase is involved in rabies virus infection through its interaction with viral phosphoprotein P. J Virol. 2015 Feb;89(3):1640-51.
• Wiltzer L, Okada K, Yamaoka S, Larrous F, Kusisto HV, Sugiyama M, Blondel D, Bourhy H, Jans DA, Ito N, Moseley GW. Interaction of Rabies Virus P-Protein With STAT Proteins is Critical to Lethal Rabies Disease. J Infect. Dis. (2014) 209 (11): 1744-1753.