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Présentation
Projets
CV
(EN)
Florence LARROUS, PhD, IP
EDUCATION
2013 PhD thesis, Microbiology, University Paris Diderot (Paris VII)
1990 BTS Biotechnology, ENCPB, Paris 13
RESEARCH and PRofessional EXPERIENCE
2014- present Research engineer in DyLah Unit,
2000-2013 Technician in DyLah Unit (Pasteur Institut)
1990-2000 Technician in Texcell (Pasteur Institut)
SCIENTIFIC ACTIVITIES
19 publications, 1 international patent – Hisch h index : 13
ADMINISTRATIVE RESPONSIBILITIES and EXPERTISE
– Technical competencies:
Virology, cellular and molecular biology
Reverse genetic on negative strand RNA virus
Public health activities on rabies diagnosis
Work according to quality assurance (AFNOR ISO17025 and ISO15189)
– Coaching competencies:
Supervision of license or master students
Participation in coaching of PhD students
Technical manager for technician for rabies diagnosis activities
– Main research project:
Study of molecular targets for the development of new antiviral strategies (replication complex of lyssaviruses).
Role of the M and P proteins in the host-lyssavirus interplay
MOST SIGNIFICANT PUBLICATION IN THE LAST FIVE YEARS
- Ben Khalifa Y*, Luco S*, Besson B, Sonthonnax F, Archambaud M, Grimes JM, Larrous F Bourhy H; The matrix protein of rabies virus binds to RelAp43 to modulate NF-κB-dependent gene expression related to innate immunity. Sci Rep. 2016 Dec 21;6:39420.
- Dacheux L*., Larrous F.*, Lavenir R, Lepelletier A, Faouzi A, Troupin C, Nourlil J, Buchy P, Bourhy H ; Dual Combined Real-Time Reverse Transcriptase Polymerase Chain Reaction Assay for the Diagnosis of Lyssavirus Infection ; PLoS Negl Trop Dis. LoS Negl Trop Dis. 2016 Jul 5;10(7)
- de Thoisy B, Bourhy H, Delaval M, Pontier D, Dacheux L, Darcissac E, Donato D,Guidez A, Larrous F, Lavenir R, Salmier A, Lacoste V, Lavergne A. Bioecological ; Drivers of Rabies Virus Circulation in a Neotropical Bat Community. PLoS Negl Trop Dis. 2016 Jan 25;10(1).
- Contou D, Dacheux L, Bendib I, Jolivet S, Rodriguez C, Tomberli F, Cleret de Langavant L, Lavenir R, Lepelletier A, Larrous F, Troupin C, Bourhy H,Brun-Buisson C. Severe ketoalkalosis as initial presentation of imported human rabies in France. J Clin Microbiol. 2015 June;53(6):1979-82.
- Fouquet B, Nikolic J, Larrous F, Bourhy H, Wirblich C, Lagaudrière-Gesbert C, Blondel D. Focal adhesion kinase is involved in rabies virus infection through its interaction with viral phosphoprotein P. J Virol. 2015 Feb;89(3):1640-51.
- Wiltzer L, Okada K, Yamaoka S, Larrous F, Kusisto HV, Sugiyama M, Blondel D, Bourhy H, Jans DA, Ito N, Moseley GW. Interaction of Rabies Virus P-Protein With STAT Proteins is Critical to Lethal Rabies Disease. J Infect. Dis. (2014) 209 (11): 1744-1753.
Publications
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2022Susceptibilities of CNS Cells towards Rabies Virus Infection Is Linked to Cellular Innate Immune Responses., Viruses 2022 Dec; 15(1): .
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2021Early Transcriptional Changes in Rabies Virus-Infected Neurons and Their Impact on Neuronal Functions., Front Microbiol 2021 ; 12(): 730892.
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2021A live measles-vectored COVID-19 vaccine induces strong immunity and protection from SARS-CoV-2 challenge in mice and hamsters., Nat Commun 2021 11; 12(1): 6277.
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2021Attenuation of clinical and immunological outcomes during SARS-CoV-2 infection by ivermectin., EMBO Mol Med 2021 08; 13(8): e14122.
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2021COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters., Sci Transl Med 2021 06; 13(596): .
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2020Structure of the prefusion-locking broadly neutralizing antibody RVC20 bound to the rabies virus glycoprotein., Nat Commun 2020 01; 11(1): 596.
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2019Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface, Cell Rep 2019 Nov;29(7):1934-1945.e8.
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2019Lyssavirus matrix protein cooperates with phosphoprotein to modulate the Jak-Stat pathway, Sci Rep 2019 Aug;9(1):12171.
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2019Kinome-Wide RNA Interference Screening Identifies Mitogen-Activated Protein Kinases and Phosphatidylinositol Metabolism as Key Factors for Rabies Virus Infection, mSphere 2019 05;4(3).
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2018Pyrimethamine inhibits rabies virus replication in vitro, Antiviral Res. 2019 01;161:1-9.
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