Genomic taxonomy of bacterial strains: universal nomenclatures for epidemiology and population biology
High-throughput sequencing has revolutionized our abilities to track and characterize novel bacterial strains as they emerge and disseminate globally. Genome-based epidemiological typing systems provide ultimate resolution for strain discrimination. Genome sequences may also be […]
Expanding the toolbox for genetic manipulation of Leptospira spp.
In comparison to other bacterial species, genetics and molecular basis of the pathogenesis of leptospires are in their infancy. An improved understanding of leptospiral pathogenesis requires reliable genetic tools for functional genetic analysis of […]
Phenotypic characterization of transposon mutants in the pathogen L. interrogans
Site-directed homologous recombination has not been successful in pathogenic Leptospira and there exist only a few examples of mutants obtained by targeted mutagenesis. We have generated a library of random mutants in the pathogen […]
Cell morphology and motility in Leptospira spp.
Leptospira spp. are thin, highly motile, slow-growing spirochetes that can be distinguished from other bacteria on the basis of their unique helical shape and the presence of periplasmic flagella. We showed that peptidoglycan sacculi […]
Exoproteins and Leucin-Rich Repeat (LRR) proteins in Leptospira spp.
The roles of leptospiral exoproteins in the mechanisms of disease manifestation in the host have not been determined. We assessed the composition and quantity of exoproteins of pathogenic L. interrogans and their contribution to […]
Development and evaluation of rapid diagnostic tests on leptospirosis
Early laboratory diagnosis of leptospirosis is important to provide appropriate treatment of patients and to take rapid measures in case of an outbreak. Unfortunately, few tests possess both high sensitivity and specificity; this is […]
Molecular and serological investigations on leptospirosis
The genus Leptospira includes 35 Leptospira species, including L. mayottensis (see below), and more than 300 serovars have been described. Little is known about the circulating etiological agents of leptospirosis in most of the […]
2021International Committee on Systematics of Prokaryotes Subcommittee on the taxonomy of Leptospiraceae Minutes of the closed meeting, 10 July 2019, Vancouver, British Columbia, Canada., Int J Syst Evol Microbiol 2021 Aug; 71(8): .
2021Ending the Neglect of Treatable Bacterial Zoonoses Responsible for Non-Malaria Fevers., Yale J Biol Med 2021 Jun; 94(2): 351-360.
2021Correction: 12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka., PLoS Negl Trop Dis 2021 May; 15(5): e0009471.
2021Leptospira dzianensis and Leptospira putramalaysiae are later heterotypic synonyms of Leptospira yasudae and Leptospira stimsonii., Int J Syst Evol Microbiol 2021 Feb; (): .
2021Pathogenic Leptospira and water quality in African cities: A case study of Cotonou, Benin., Sci Total Environ 2021 Feb; 774(): 145541.
2021Effect of disinfection agents and quantification of potentially viable Leptospira in fresh water samples using a highly sensitive integrity-qPCR assay., PLoS One 2021 ; 16(5): e0251901.
20204-Methylcytosine DNA modification is critical for global epigenetic regulation and virulence in the human pathogen Leptospira interrogans., Nucleic Acids Res 2020 Dec; 48(21): 12102-12115.
2020Toolbox of Molecular Techniques for Studying Leptospira Spp., Curr Top Microbiol Immunol ; 415(): 141-162.
2020The transcriptional response of pathogenic Leptospira to peroxide reveals new defenses against infection-related oxidative stress., PLoS Pathog 2020 Oct; 16(10): e1008904.
2020Circulating genotypes of Leptospira in French Polynesia : An 9-year molecular epidemiology surveillance follow-up study., PLoS Negl Trop Dis 2020 09; 14(9): e0008662.
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