Genomic taxonomy of bacterial strains: universal nomenclatures for epidemiology and population biology
High-throughput sequencing has revolutionized our abilities to track and characterize novel bacterial strains as they emerge and disseminate globally. Genome-based epidemiological typing systems provide ultimate resolution for strain discrimination. Genome sequences may also be […]
Expanding the toolbox for genetic manipulation of Leptospira spp.
In comparison to other bacterial species, genetics and molecular basis of the pathogenesis of leptospires are in their infancy. An improved understanding of leptospiral pathogenesis requires reliable genetic tools for functional genetic analysis of […]
Phenotypic characterization of transposon mutants in the pathogen L. interrogans
Site-directed homologous recombination has not been successful in pathogenic Leptospira and there exist only a few examples of mutants obtained by targeted mutagenesis. We have generated a library of random mutants in the pathogen […]
Cell morphology and motility in Leptospira spp.
Leptospira spp. are thin, highly motile, slow-growing spirochetes that can be distinguished from other bacteria on the basis of their unique helical shape and the presence of periplasmic flagella. We showed that peptidoglycan sacculi […]
Exoproteins and Leucin-Rich Repeat (LRR) proteins in Leptospira spp.
The roles of leptospiral exoproteins in the mechanisms of disease manifestation in the host have not been determined. We assessed the composition and quantity of exoproteins of pathogenic L. interrogans and their contribution to […]
Development and evaluation of rapid diagnostic tests on leptospirosis
Early laboratory diagnosis of leptospirosis is important to provide appropriate treatment of patients and to take rapid measures in case of an outbreak. Unfortunately, few tests possess both high sensitivity and specificity; this is […]
Molecular and serological investigations on leptospirosis
The genus Leptospira includes 35 Leptospira species, including L. mayottensis (see below), and more than 300 serovars have been described. Little is known about the circulating etiological agents of leptospirosis in most of the […]
BIGSdb-Pasteur is the genomic-based strain taxonomy and nomenclature platform of Institut Pasteur, powered by the BIGSdb software developed at Oxford University. This web platform hosts collections of curated, open or private databases of bacterial […]
2023Horizontal transfer of the rfb cluster in Leptospira is a genetic determinant of serovar identity., Life Sci Alliance 2023 Feb; 6(2): .
2022Diving into the complexity of the spirochetal endoflagellum., Trends Microbiol 2022 Oct; (): .
2022Zoonoses and gold mining: A cross-sectional study to assess yellow fever immunization, Q fever, leptospirosis and leishmaniasis among the population working on illegal mining camps in French Guiana., PLoS Negl Trop Dis 2022 Aug; 16(8): e0010326.
2022Corrigendum: Escape of TLR5 recognition by Leptospira spp.: A rationale for atypical endoflagella., Front Immunol 2022 ; 13(): 932151.
2021Investigating the role of the carbon storage regulator A (CsrA) Leptospira spp., PLoS One . 2021 Dec 13;16(12):e0260981.
2021The FUR-like regulators PerRA and PerRB integrate a complex regulatory network that promotes mammalian host-adaptation and virulence of Leptospira interrogans., PLoS Pathog 2021 Dec; 17(12): e1009078.
2021Genetic diversity of Leptospira isolates in Lao PDR and genome analysis of an outbreak strain., PLoS Negl Trop Dis 2021 12; 15(12): e0010076.
2021The oxidative stress response of pathogenic Leptospira is controlled by two peroxide stress regulators which putatively cooperate in controlling virulence., PLoS Pathog 2021 Dec; 17(12): e1009087.
2021Leptospira ainlahdjerensis sp. nov., Leptospira ainazelensis sp. nov., Leptospira abararensis sp. nov. and Leptospira chreensis sp. nov., four new species isolated from water sources in Algeria., Int J Syst Evol Microbiol 2021 Dec; 71(12): .
2021Role of the major determinant of polar flagellation FlhG in the endoflagella-containing spirochete Leptospira., Mol Microbiol 2021 Oct; (): .
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