EpiKillMal- Use of DNA methyltransferase inhibitors to kill drug-resistant malaria parasites –
Malaria remains a major global health problem due to the increasing spread of drug resistance and more than 400,000 deaths per year. New drugs that target multidrug resistant parasites are of highest priority. The […]
Targeting Malaria Epigenetics
Malaria is a tropical disease due to a parasite named Plasmodium. It is a global health problem, still causing more than 450.000 deaths each year (mostly African children) and over 200 million infections (http://www.who.int/malaria/en/). […]
Alkoxypyrazoles, inhibitors of dihydroorotate dehydrogenase (DHODH)
A thousand fold improvement of an antiviral activity The starting point of this project was the modest activity displayed by compounds 1 and 2, on the phenotypic Measles-based antiviral assay designed by Pierre-Olivier Vidalain […]
P. berghei, a rodent malaria model to investigate host-parasite interactions central for malaria pathogenesis
During the past year, using a murine model for experimental cerebral malaria (ECM), we pursued our investigation regarding the contribution of the allergic inflammatory response in the pathogenesis of malaria disease. Following the demonstration […]
Identification of parasite co-factors that are critical for adhesion of P. falciparum–infected RBC
Although PfEMP1/var is studied in many laboratories in the world, a number of key questions remain unknown. By analysing a mutant parasite (D10) with a chromosome 9 deletion and loss of adhesion, we linked […]
Targeting epigenetic factors for new intervention strategies
Our basic research on virulence gene control revealed that epigenetic factors such as histone methylation control antigenic variation but also the developmental progression of malaria parasites during the complex life cycle in the […]
Nuclear biology and the identification of novel chromatin factors linked to the control of virulence gene expression and genome variability
Fig. 2: Transmission electron micrograph of an iRBC (schizont). Nucleus shown in blue. Only few factors that interact with the DNA of P. falciparum have been identified and the recruitment of specific factors […]
Molecular mechanism of antigenic variation of P. falciparum
The protozoan pathogen P. falciparum undergoes antigenic variation to establish persistent blood stage infection. Several clonally variant gene families undergo antigenic variation in P. falciparum and are expressed during blood stage infection at […]
From basic research to new intervention strategies against malaria parasites
The Leitmotif of the BIHP research group can be summarized as follows: “From basic research to new intervention strategies against malaria parasites”. The teams investigate various topics related to blood stage infection such as […]
2023Cohesin contributes to transcriptional repression of stage-specific genes in the human malaria parasite., EMBO Rep 2023 Aug; (): e57090.
2023Plasmodium falciparum Eukaryotic Translation Initiation Factor 3 is Stabilized by Quinazoline-Quinoline Bisubstrate Inhibitors., ACS Infect Dis 2023 May; (): .
2023Hemisynthetic alkaloids derived from trilobine are antimalarials with sustained activity in multidrug-resistant Plasmodium falciparum., iScience 2023 Feb; 26(2): 105940.
2023Discovery of RUF6 ncRNA-interacting proteins involved in P. falciparum immune evasion., Life Sci Alliance 2023 Jan; 6(1): .
2023Plasmodium-encoded murine IL-6 impairs liver stage infection and elicits long-lasting sterilizing immunity., Front Immunol 2023 ; 14(): 1143012.
2022Humanized mice for investigating sustained Plasmodium vivax blood-stage infections and transmission., Nat Commun 2022 Jul; 13(1): 4123.
2021Malaria Parasite Stress Tolerance Is Regulated by DNMT2-Mediated tRNA Cytosine Methylation, mBio. 2021 Nov-Dec; 12(6): e02558-21.
2021Flowcytometric and ImageStream Rna-Fish Gene Expression, Quantification and Phenotypic Characterization of Blood Sporozoites and Sporozoites From Human Malaria Species., J Infect Dis 2022 05; 225(9): 1621-1625.
2021Procainamide-SAHA Fused Inhibitors of hHDAC6 Tackle Multidrug-Resistant Malaria Parasites., J Med Chem 2021 07; 64(14): 10403-10417.
2021Functional Characterization of the m6A-Dependent Translational Modulator PfYTH.2 in the Human Malaria Parasite., mBio 2021 04; 12(2): .
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