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Connexions
Équipements
Embryo Microinjection Station • Nikon TE2000 •
Microscope +Transferman NK2 Micromanipulators and Femtojet, Cell Tram Air, Cell Tram Oil MIcroinjectors. The system (manual at the microscope level) allow, like the ASTP station above-mentioned, the storage and recall of positions and the […]
Embryo Reimplantation Station • Nikon Stereomicroscopes SMZ800 (episcopic base/diascopic base) •
The diascopic stereomicroscope allows embryo counting and the preparation of the reimplantation pipette. The stereomicroscope coupled to a coaxial Episcopic Illuminator (Fibber Optic Light Source) offers bright illumination over the entire surface of the […]
Eukaryotic Cell Electroporator • Bio-Rad Gene Pulser X Cell Total System •
The electroporator (with the appropriated parameters) gives the necessary pulse for the entering of the gene targeting vector or recombinase-expressing plasmid into the Embryonic Stem (ES) Cells.
XY Clone Laser System • Hamilton Thorne Bioscience •
The laser module, attached just like a typical objective, permits non-contact ablation of targeted membranes. It is mainly used in transgenesis for ablation of the zona pellucida for microinjection of eight-cell and morula stage […]
Piezo Impact Micromanipulator • PRIME TECH, Dipsi Industrie •
The piezo-assisted microinjection increases success rates for transgenesis by IntraCytoplasmic Sperm Injection (ICSI), where sperm are coated with exogenous DNA and injected into oocytes. The piezo impact drive, attached to the injecting micropipette holder, […]
Embryo Microinjection Station • Leica ASTP •
Station including Transferman NK2 Micromanipulators and Femtojet, Cell Tram Air, Cell Tram Oil MIcroinjectors. The system combines the operation of both microscope and micromanipulators into one user-oriented control unit (first motorized integrated transgenic platform). […]
Membres
Francina Langa Vives
Responsable de Structure
Responsable
Anciens Membres
2000
2000
Name
Position
2015
2020
Carine Moigneu
Technician
2015
2020
Gaëlle Chauveau-Le Friec
Technician
2015
2020
Laetitia Joullie
Technician
Projets
Publications
Télécharger-
2024Nr5a2 is dispensable for zygotic genome activation but essential for morula development, Science, 2024, 386 (6717), pp.eadg7325. ⟨10.1126/science.adg7325⟩.
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2023A human immune system (HIS) mouse model that dissociates roles for mouse and human FcR+ cells during antibody-mediated immune responses., Eur J Immunol 2023 Aug; (): e2350454.
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2023Mice Humanized for MHC and hACE2 with High Permissiveness to SARS-CoV-2 Omicron Replication., Microbes Infect 2023 Apr; (): 105142.
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2022SPICE-Met: profiling and imaging energy metabolism at the single-cell level using a fluorescent reporter mouse., EMBO J 2022 Aug; (): e111528.
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2022An intranasal lentiviral booster reinforces the waning mRNA vaccine-induced SARS-CoV-2 immunity that it targets to lung mucosa., Mol Ther 2022 Apr; (): .
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2022A fast Myosin super enhancer dictates muscle fiber phenotype through competitive interactions with Myosin genes., Nat Commun 2022 02; 13(1): 1039.
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2021Brain cross-protection against SARS-CoV-2 variants by a lentiviral vaccine in new transgenic mice., EMBO Mol Med 2021 12; 13(12): e14459.
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2021De novo germline mutation in the dual specificity phosphatase 10 gene accelerates autoimmune diabetes., Proc Natl Acad Sci U S A 2021 11; 118(47): .
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2021The antitumoral effects of chemerin are independent from leukocyte recruitment and mediated by inhibition of neoangiogenesis., Oncotarget 2021 Sep; 12(19): 1903-1919.
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2021The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium., Nat Commun 2021 08; 12(1): 4810.
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+Voir la liste complète de publications
Contact
Phone: 01 44 38 95 66 Email: francina.langa-vives@pasteur.fr Centre d’Ingénierie Génétique Murine Bâtiment François Jacob 1er étage 28, rue du Dr. Roux 75015, Paris France