Présentation
We have an increasing experience in modification on rat genome using lentiviral vectors and Zinc Finger Nucleases (ZFNs). Rat models are more convenient for surgery, due to their medium size, and constitute a robust physiological model for pharmacological studies. Rats give also better models for neurology (specially behaviour studies), hypertension, diabetes and also some cancers (sarcoma, breast cancer) where they mimic more accurately the human disease.