Marco Bellinzoni

Despite the conservation of central metabolism, an increasing amount of evidence indicates that there are unique features in Actinobacteria, one of the largest bacterial phyla that includes important human pathogens like Mycobacterium tuberculosis and […]

Tuberculosis still remains a major threat for public health, with one-third of the world population latently infected, and more than one million deaths per year according to the WHO. Among the factors that have […]

Acyl-CoAs are the major metabolic carriers of carbon in living organisms. The most conserved ways to their synthesis include the oxidative decarboxylation of α-ketoacids carried out by three distinct enzymatic machineries: the pyruvate dehydrogenase […]

  The genes pknA and pknB are located near the origin of replication in M. tuberculosis and are part of a conserved operon that also includes pstP (coding the only known Ser/Thr protein phosphatase […]

  We recently demonstrated the existence of a phosphorylation-dependent control of glutamate metabolism in mycobacteria, in collaboration with H. O’Hare’s group in Leicester (O’Hare et al., 2008). Our results were supported by similar observations […]