Timeline

Emmanuel Lemichez

Head of Structure

22 Mar 2024

publication

Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane.

01 Dec 2023

publication

Parvimonas micra, an oral pathobiont associated with colorectal cancer, epigenetically reprograms human colonocytes.

09 Nov 2023

news

EuroBioTox in the “Results in Brief” of the European Commission’s CORDIS website

13 Oct 2022

publication

Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division.

05 Oct 2022

publication

The cnf1 gene is associated with an expanding Escherichia coli ST131 H30Rx/C2 subclade and confers a competitive advantage for gut colonization.

17 Sep 2022

publication

In Silico Conformational Features of Botulinum Toxins A1 and E1 According to Intraluminal Acidification.

15 Jul 2022

publication

C910 chemical compound inhibits the traffiking of several bacterial AB toxins with cross-protection against influenza virus.

20 Jan 2022

team

U1306 – Host-Microbe interactions and pathophysiology

08 Dec 2021

publication

DHA-phospholipids control membrane fusion and transcellular tunnel dynamics.

20 Sep 2021

publication

Conformational Insights into the Control of CNF1 Toxin Activity by Peptidyl-Prolyl Isomerization: A Molecular Dynamics Perspective.

01 May 2021

publication

Characterization of a highly neutralizing single monoclonal antibody to botulinum neurotoxin type A.

13 Sep 2019

project

Chronic carriage of CNF1-producing bacteria in the gut and development of colorectal cancer

13 Sep 2019

project

Landscape of protein ubiquitylation during infection by CNF1-producing uropathogenic E. coli

23 Jul 2019

project

Endothelium disruption by toxin-induced transcellular tunnels

23 Jul 2019

project

CNF1 and Rho GTPases ubiquitylation in cellular invasion by uropathogenic E. coli

23 Jul 2019

project

Detection and countermeasures against bacterial toxins

20 Apr 2019

publication

UBTD1 is a mechano-regulator controlling cancer aggressiveness

20 Sep 2018

publication

Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

13 Sep 2018

publication

Variability of Botulinum Toxins: Challenges and Opportunities for the Future

14 Feb 2018

publication

Botulinum Neurotoxins: Still a Privilege of Clostridia?

01 Feb 2018

publication

Decoding glycan recognition by bacterial toxins

23 Jan 2018

publication

Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination

23 Jan 2018

publication

Screening of a Drug Library Identifies Inhibitors of Cell Intoxication by CNF1.

18 Jan 2018

publication

“Bacterial Toxins” Section in the Journal Toxins: A Fantastic Multidisciplinary Interplay between Bacterial Pathogenicity Mechanisms, Physiological Processes, Genomic Evolution, and Subsequent Development of Identification Methods, Efficient Treatment, and Prevention of Toxigenic Bacteria

09 Aug 2017

publication

Force-induced transcellular tunnel formation in endothelial cells

06 Jul 2017

team

Bacterial Toxins

23 Jun 2017

publication

Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation

02 Jun 2017

publication

Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells

18 May 2017

publication

Pseudomonas aeruginosa Exolysin promotes bacterial growth in lungs, alveolar damage and bacterial dissemination

24 Apr 2017

publication

Staphylococcus aureus Promotes Smed-PGRP-2/Smed-setd8-1 Methyltransferase Signalling in Planarian Neoblasts to Sensitize Anti-bacterial Gene Responses During Re-infection

20 Mar 2017

publication

Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation

16 Mar 2017

publication

Decrease of Staphylococcus aureus Virulence by Helcococcus kunzii in a Caenorhabditis elegans Model

11 Mar 2017

publication

Botulinum neurotoxin type B uses a distinct entry pathway mediated by CDC42 into intestinal cells versus neuronal cells

18 Jan 2017

publication

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature

01 Jan 2017

publication

New Aspects on Bacterial Effectors Targeting Rho GTPases

25 Aug 2016

publication

Development of Germline-Humanized Antibodies Neutralizing Botulinum Neurotoxin A and B

07 Aug 2016

publication

First isolation of Clostridium indolis in a patient with chronic osteitis: a case report and literature review of human infections related to Clostridium saccharolyticum group species

13 Jun 2016

publication

Diversity of Group I and II Clostridium botulinum Strains from France Including Recently Identified Subtypes

03 Jun 2016

publication

Immunoadjuvant Properties of the Rho Activating Factor CNF1 in Prophylactic and Curative Vaccination against Leishmania infantum.

21 Apr 2016

publication

A penicillin- and metronidazole-resistant Clostridium botulinum strain responsible for an infant botulism case

01 Apr 2016

publication

EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin

25 Mar 2016

publication

The Tip of the Four N-Terminal α-Helices of Clostridium sordellii Lethal Toxin Contains the Interaction Site with Membrane Phosphatidylserine Facilitating Small GTPases Glucosylation

03 Mar 2016

publication

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

03 Feb 2016

publication

A novel Hsp70 inhibitor prevents cell intoxication with the actin ADP-ribosylating Clostridium perfringens iota toxin

02 Feb 2016

publication

Microbial pathogenesis meets biomechanics

01 Feb 2016

publication

Translocation and dissemination to target neurons of botulinum neurotoxin type B in the mouse intestinal wall.

01 Jan 2016

publication

A cluster of three cases of botulism due to Clostridium baratii type F, France, August 2015

01 Oct 2015

publication

Contractile actin cables induced by Bacillus anthracis lethal toxin depend on the histone acetylation machinery.

14 Aug 2015

publication

Pore-forming activity of clostridial binary toxins

08 Oct 2012

publication

Role of N-terminal His6-Tags in binding and efficient translocation of polypeptides into cells using anthrax protective antigen (PA)

05 Aug 2011

publication

Cross-reactivity of anthrax and C2 toxin: protective antigen promotes the uptake of botulinum C2I toxin into human endothelial cells

25 Feb 2011

publication

Escherichia coli producing CNF1 toxin hijacks Tollip to trigger Rac1-dependent cell invasion

20 May 2010

publication

Transcriptome dysregulation by anthrax lethal toxin plays a key role in induction of human endothelial cell cytotoxicity

22 Jun 2009

publication

Injection of Staphylococcus aureus EDIN by the Bacillus anthracis protective antigen machinery induces vascular permeability

20 Mar 2008

publication

Isoform-specific interaction of C-RAF with mitochondria

05 Jun 2006

publication

A little guide for advanced search:

Caveolin-1 protects endothelial cells from extensive expansion of transcellular tunnel by stiffening the plasma membrane.

Parvimonas micra, an oral pathobiont associated with colorectal cancer, epigenetically reprograms human colonocytes.

EuroBioTox in the “Results in Brief” of the European Commission’s CORDIS website

Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division.

The cnf1 gene is associated with an expanding Escherichia coli ST131 H30Rx/C2 subclade and confers a competitive advantage for gut colonization.

In Silico Conformational Features of Botulinum Toxins A1 and E1 According to Intraluminal Acidification.

C910 chemical compound inhibits the traffiking of several bacterial AB toxins with cross-protection against influenza virus.

U1306 – Host-Microbe interactions and pathophysiology

DHA-phospholipids control membrane fusion and transcellular tunnel dynamics.

Conformational Insights into the Control of CNF1 Toxin Activity by Peptidyl-Prolyl Isomerization: A Molecular Dynamics Perspective.

Characterization of a highly neutralizing single monoclonal antibody to botulinum neurotoxin type A.

Chronic carriage of CNF1-producing bacteria in the gut and development of colorectal cancer

Landscape of protein ubiquitylation during infection by CNF1-producing uropathogenic E. coli

Endothelium disruption by toxin-induced transcellular tunnels

CNF1 and Rho GTPases ubiquitylation in cellular invasion by uropathogenic E. coli

Detection and countermeasures against bacterial toxins

UBTD1 is a mechano-regulator controlling cancer aggressiveness

Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

Variability of Botulinum Toxins: Challenges and Opportunities for the Future

Botulinum Neurotoxins: Still a Privilege of Clostridia?

Decoding glycan recognition by bacterial toxins

Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination

Screening of a Drug Library Identifies Inhibitors of Cell Intoxication by CNF1.

“Bacterial Toxins” Section in the Journal Toxins: A Fantastic Multidisciplinary Interplay between Bacterial Pathogenicity Mechanisms, Physiological Processes, Genomic Evolution, and Subsequent Development of Identification Methods, Efficient Treatment, and Prevention of Toxigenic Bacteria

Force-induced transcellular tunnel formation in endothelial cells

Bacterial Toxins

Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation

Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells

Pseudomonas aeruginosa Exolysin promotes bacterial growth in lungs, alveolar damage and bacterial dissemination

Staphylococcus aureus Promotes Smed-PGRP-2/Smed-setd8-1 Methyltransferase Signalling in Planarian Neoblasts to Sensitize Anti-bacterial Gene Responses During Re-infection

Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation

Decrease of Staphylococcus aureus Virulence by Helcococcus kunzii in a Caenorhabditis elegans Model

Botulinum neurotoxin type B uses a distinct entry pathway mediated by CDC42 into intestinal cells versus neuronal cells

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature

New Aspects on Bacterial Effectors Targeting Rho GTPases

Development of Germline-Humanized Antibodies Neutralizing Botulinum Neurotoxin A and B

First isolation of Clostridium indolis in a patient with chronic osteitis: a case report and literature review of human infections related to Clostridium saccharolyticum group species

Diversity of Group I and II Clostridium botulinum Strains from France Including Recently Identified Subtypes

Immunoadjuvant Properties of the Rho Activating Factor CNF1 in Prophylactic and Curative Vaccination against Leishmania infantum.

A penicillin- and metronidazole-resistant Clostridium botulinum strain responsible for an infant botulism case

EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin

The Tip of the Four N-Terminal α-Helices of Clostridium sordellii Lethal Toxin Contains the Interaction Site with Membrane Phosphatidylserine Facilitating Small GTPases Glucosylation

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

A novel Hsp70 inhibitor prevents cell intoxication with the actin ADP-ribosylating Clostridium perfringens iota toxin

Microbial pathogenesis meets biomechanics

Translocation and dissemination to target neurons of botulinum neurotoxin type B in the mouse intestinal wall.

A cluster of three cases of botulism due to Clostridium baratii type F, France, August 2015

Contractile actin cables induced by Bacillus anthracis lethal toxin depend on the histone acetylation machinery.

Pore-forming activity of clostridial binary toxins

Role of N-terminal His6-Tags in binding and efficient translocation of polypeptides into cells using anthrax protective antigen (PA)

Cross-reactivity of anthrax and C2 toxin: protective antigen promotes the uptake of botulinum C2I toxin into human endothelial cells

Escherichia coli producing CNF1 toxin hijacks Tollip to trigger Rac1-dependent cell invasion

Transcriptome dysregulation by anthrax lethal toxin plays a key role in induction of human endothelial cell cytotoxicity

Injection of Staphylococcus aureus EDIN by the Bacillus anthracis protective antigen machinery induces vascular permeability

Isoform-specific interaction of C-RAF with mitochondria

Induction of transient macroapertures in endothelial cells through RhoA inhibition by Staphylococcus aureus factors.