Ligne de temps

Emmanuel Lemichez
Responsable de Structure
13 oct. 2022
publication

Optineurin links Hace1-dependent Rac ubiquitylation to integrin-mediated mechanotransduction to control bacterial invasion and cell division.

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05 oct. 2022
publication

The cnf1 gene is associated with an expanding Escherichia coli ST131 H30Rx/C2 subclade and confers a competitive advantage for gut colonization.

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17 sept. 2022
publication

In Silico Conformational Features of Botulinum Toxins A1 and E1 According to Intraluminal Acidification.

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15 juil. 2022
publication

C910 chemical compound inhibits the traffiking of several bacterial AB toxins with cross-protection against influenza virus.

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08 déc. 2021
publication

DHA-phospholipids control membrane fusion and transcellular tunnel dynamics.

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20 sept. 2021
publication

Conformational Insights into the Control of CNF1 Toxin Activity by Peptidyl-Prolyl Isomerization: A Molecular Dynamics Perspective.

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01 mai 2021
publication

Characterization of a highly neutralizing single monoclonal antibody to botulinum neurotoxin type A.

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13 sept. 2019
project

Chronic carriage of CNF1-producing bacteria in the gut and development of colorectal cancer

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13 sept. 2019
project

Landscape of protein ubiquitylation during infection by CNF1-producing uropathogenic E. coli

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23 juil. 2019
project

Endothelium disruption by toxin-induced transcellular tunnels

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23 juil. 2019
project

CNF1 and Rho GTPases ubiquitylation in cellular invasion by uropathogenic E. coli

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23 juil. 2019
project

Detection and countermeasures against bacterial toxins

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20 avr. 2019
publication

UBTD1 is a mechano-regulator controlling cancer aggressiveness

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20 sept. 2018
publication

Ezrin enrichment on curved membranes requires a specific conformation or interaction with a curvature-sensitive partner

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13 sept. 2018
publication

Variability of Botulinum Toxins: Challenges and Opportunities for the Future

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14 févr. 2018
publication

Botulinum Neurotoxins: Still a Privilege of Clostridia?

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01 févr. 2018
publication

Decoding glycan recognition by bacterial toxins

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23 janv. 2018
publication

Group-I PAKs-mediated phosphorylation of HACE1 at serine 385 regulates its oligomerization state and Rac1 ubiquitination

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23 janv. 2018
publication

Screening of a Drug Library Identifies Inhibitors of Cell Intoxication by CNF1.

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18 janv. 2018
publication

“Bacterial Toxins” Section in the Journal Toxins: A Fantastic Multidisciplinary Interplay between Bacterial Pathogenicity Mechanisms, Physiological Processes, Genomic Evolution, and Subsequent Development of Identification Methods, Efficient Treatment, and Prevention of Toxigenic Bacteria

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09 août 2017
publication

Force-induced transcellular tunnel formation in endothelial cells

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06 juil. 2017
team

Toxines Bactériennes

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23 juin 2017
publication

Ezrin enhances line tension along transcellular tunnel edges via NMIIa driven actomyosin cable formation

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02 juin 2017
publication

Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells

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18 mai 2017
publication

Pseudomonas aeruginosa Exolysin promotes bacterial growth in lungs, alveolar damage and bacterial dissemination

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24 avr. 2017
publication

Staphylococcus aureus Promotes Smed-PGRP-2/Smed-setd8-1 Methyltransferase Signalling in Planarian Neoblasts to Sensitize Anti-bacterial Gene Responses During Re-infection

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20 mars 2017
publication

Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation

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16 mars 2017
publication

Decrease of Staphylococcus aureus Virulence by Helcococcus kunzii in a Caenorhabditis elegans Model

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11 mars 2017
publication

Botulinum neurotoxin type B uses a distinct entry pathway mediated by CDC42 into intestinal cells versus neuronal cells

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18 janv. 2017
publication

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature

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01 janv. 2017
publication

New Aspects on Bacterial Effectors Targeting Rho GTPases

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25 août 2016
publication

Development of Germline-Humanized Antibodies Neutralizing Botulinum Neurotoxin A and B

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07 août 2016
publication

First isolation of Clostridium indolis in a patient with chronic osteitis: a case report and literature review of human infections related to Clostridium saccharolyticum group species

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13 juin 2016
publication

Diversity of Group I and II Clostridium botulinum Strains from France Including Recently Identified Subtypes

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03 juin 2016
publication

Immunoadjuvant Properties of the Rho Activating Factor CNF1 in Prophylactic and Curative Vaccination against Leishmania infantum.

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21 avr. 2016
publication

A penicillin- and metronidazole-resistant Clostridium botulinum strain responsible for an infant botulism case

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01 avr. 2016
publication

EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin

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25 mars 2016
publication

The Tip of the Four N-Terminal α-Helices of Clostridium sordellii Lethal Toxin Contains the Interaction Site with Membrane Phosphatidylserine Facilitating Small GTPases Glucosylation

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03 mars 2016
publication

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

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03 févr. 2016
publication

A novel Hsp70 inhibitor prevents cell intoxication with the actin ADP-ribosylating Clostridium perfringens iota toxin

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02 févr. 2016
publication

Microbial pathogenesis meets biomechanics

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01 févr. 2016
publication

Translocation and dissemination to target neurons of botulinum neurotoxin type B in the mouse intestinal wall.

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01 janv. 2016
publication

A cluster of three cases of botulism due to Clostridium baratii type F, France, August 2015

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01 oct. 2015
publication

Contractile actin cables induced by Bacillus anthracis lethal toxin depend on the histone acetylation machinery.

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14 août 2015
publication

Pore-forming activity of clostridial binary toxins

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01 juin 2006
publication

Induction of transient macroapertures in endothelial cells through RhoA inhibition by Staphylococcus aureus factors.

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