Timeline

Jean-Pierre Vartanian

Head of Structure

17 Feb 2025

event

Institut Pasteur – Sorbonne Université Symposium

07 Jan 2025

publication

Cobalt chloride-mimicked hepatocyte cell hypoxia induces TREX1 leading to Hepatitis B virus restriction.

08 Jan 2024

event

Club viro: SARS-CoV2 RBD-Specific Antibodies /// APOBEC3F & Monkeypox virus

22 Dec 2023

course

Viral Outbreaks and Pandemics, A One Health Approach MOOC

08 Sep 2023

event

Club viro: Influenza A virus & TDP-43 /// SARS-CoV-2-mediated cell hijacking

24 May 2023

publication

APOBEC3F is a mutational driver of the human Monkeypox virus identified in the 2022 outbreak.

04 Jan 2023

team

Virus and cellular stress

08 Nov 2022

event

« Population dynamics of RNA arthropod-borne viruses in experimental evolution »

15 Sep 2022

event

“Structural biology of beneficial viruses: the anatomy of a flagellotropic bacteriophage and surprises in the architecture of flaviviruses.”

12 Jan 2022

publication

APOBEC3C S188I Polymorphism Enhances Context-Specific Editing of Hepatitis B Virus Genome.

16 Dec 2021

course

Emerging and re-emerging viruses MOOC

09 Sep 2021

course

MOOC Viruses and Human Cancers

14 Aug 2021

publication

Frame-shifted APOBEC3A encodes two alternative proapoptotic proteins that target the mitochondrial network.

01 Apr 2019

publication

Hypoxia-induced human deoxyribonuclease I is a cellular restriction factor of hepatitis B virus.

28 Feb 2019

publication

Genotoxic stress increases cytoplasmic mitochondrial DNA editing by human APOBEC3 mutator enzymes at a single cell level.

24 Jan 2019

publication

Elephant APOBEC3A cytidine deaminase induces massive double-stranded DNA breaks and apoptosis.

12 Jun 2018

publication

The rabbit as an orthologous small animal model for APOBEC3A oncogenesis.

12 Nov 2014

publication

ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity

15 Sep 2014

department

Virology

20 Aug 2013

publication

Human APOBEC3A isoforms translocate to the nucleus and induce DNA double strand breaks leading to cell stress and death

20 Jun 2013

publication

Efficient deamination of 5-methylcytidine and 5-substituted cytidine residues in DNA by human APOBEC3A cytidine deaminase

19 Sep 2012

publication

Hyperediting of human T-cell leukemia virus type 2 and simian T-cell leukemia virus type 3 by the dsRNA adenosine deaminase ADAR-1

13 Sep 2012

publication

Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A

17 Jan 2012

publication

Evolution of the primate APOBEC3A cytidine deaminase gene and identification of related coding regions

01 Jun 2011

publication

Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo

02 Mar 2011

publication

Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism

15 Dec 2010

publication

Double-stranded RNA adenosine deaminase ADAR-1-induced hypermutated genomes among inactivated seasonal influenza and live attenuated measles virus vaccines

28 May 2010

publication

APOBEC1 and APOBEC3 cytidine deaminases as restriction factors for hepadnaviral genomes in non-humans in vivo

27 May 2010

publication

Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis

21 Oct 2009

publication

Human APOBEC1 cytidine deaminase edits HBV DNA

12 Mar 2009

publication

Powerful mutators lurking in the genome

26 Jan 2009

publication

Genetic editing of HBV DNA by monodomain human APOBEC3 cytidine deaminases and the recombinant nature of APOBEC3G

01 Nov 2008

publication

Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo

30 May 2008

publication

Inversing the natural hydrogen bonding rule to selectively amplify GC-rich ADAR-edited RNAs

11 Apr 2008

publication

Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions

14 Feb 2007

publication

Induction of mutations in Drosophila melanogaster gypsy retroelements by modulation of intracellular deoxynucleoside triphosphate pools in vivo

08 Sep 2006

publication

Twin gradients in APOBEC3 edited HIV-1 DNA reflect the dynamics of lentiviral replication

01 Jan 2006

publication

Restriction of foamy viruses by APOBEC cytidine deaminases

01 Sep 2005

publication

Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases

01 Jan 2005

publication

Recovery of APOBEC3-edited human immunodeficiency virus G->A hypermutants by differential DNA denaturation PCR

15 Dec 2004

publication

A universal primer set for PCR amplification of nuclear histone H4 genes from all animal species

30 Apr 2004

publication

APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase

01 Oct 2003

publication

Death and the retrovirus

01 Apr 2003

publication

Network analysis of human and simian immunodeficiency virus sequence sets reveals massive recombination resulting in shorter pathways

01 Nov 2002

publication

Identification of a hepatitis B virus genome in wild chimpanzees (Pan troglodytes schweinfurthi) from East Africa indicates a wide geographical dispersion among equatorial African primates

28 May 2002

publication

Analysis of a library of macaque nuclear mitochondrial sequences confirms macaque origin of divergent sequences from old oral polio vaccine samples

01 Apr 2002

publication

A little guide for advanced search:

Institut Pasteur – Sorbonne Université Symposium

Cobalt chloride-mimicked hepatocyte cell hypoxia induces TREX1 leading to Hepatitis B virus restriction.

Club viro: SARS-CoV2 RBD-Specific Antibodies /// APOBEC3F & Monkeypox virus

Viral Outbreaks and Pandemics, A One Health Approach MOOC

Club viro: Influenza A virus & TDP-43 /// SARS-CoV-2-mediated cell hijacking

APOBEC3F is a mutational driver of the human Monkeypox virus identified in the 2022 outbreak.

Virus and cellular stress

« Population dynamics of RNA arthropod-borne viruses in experimental evolution »

“Structural biology of beneficial viruses: the anatomy of a flagellotropic bacteriophage and surprises in the architecture of flaviviruses.”

APOBEC3C S188I Polymorphism Enhances Context-Specific Editing of Hepatitis B Virus Genome.

Emerging and re-emerging viruses MOOC

MOOC Viruses and Human Cancers

Frame-shifted APOBEC3A encodes two alternative proapoptotic proteins that target the mitochondrial network.

Hypoxia-induced human deoxyribonuclease I is a cellular restriction factor of hepatitis B virus.

Genotoxic stress increases cytoplasmic mitochondrial DNA editing by human APOBEC3 mutator enzymes at a single cell level.

Elephant APOBEC3A cytidine deaminase induces massive double-stranded DNA breaks and apoptosis.

The rabbit as an orthologous small animal model for APOBEC3A oncogenesis.

ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity

Virology

Human APOBEC3A isoforms translocate to the nucleus and induce DNA double strand breaks leading to cell stress and death

Efficient deamination of 5-methylcytidine and 5-substituted cytidine residues in DNA by human APOBEC3A cytidine deaminase

Hyperediting of human T-cell leukemia virus type 2 and simian T-cell leukemia virus type 3 by the dsRNA adenosine deaminase ADAR-1

Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A

Evolution of the primate APOBEC3A cytidine deaminase gene and identification of related coding regions

Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo

Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism

Double-stranded RNA adenosine deaminase ADAR-1-induced hypermutated genomes among inactivated seasonal influenza and live attenuated measles virus vaccines

APOBEC1 and APOBEC3 cytidine deaminases as restriction factors for hepadnaviral genomes in non-humans in vivo

Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis

Human APOBEC1 cytidine deaminase edits HBV DNA

Powerful mutators lurking in the genome

Genetic editing of HBV DNA by monodomain human APOBEC3 cytidine deaminases and the recombinant nature of APOBEC3G

Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo

Inversing the natural hydrogen bonding rule to selectively amplify GC-rich ADAR-edited RNAs

Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions

Induction of mutations in Drosophila melanogaster gypsy retroelements by modulation of intracellular deoxynucleoside triphosphate pools in vivo

Twin gradients in APOBEC3 edited HIV-1 DNA reflect the dynamics of lentiviral replication

Restriction of foamy viruses by APOBEC cytidine deaminases

Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases

Recovery of APOBEC3-edited human immunodeficiency virus G->A hypermutants by differential DNA denaturation PCR

A universal primer set for PCR amplification of nuclear histone H4 genes from all animal species

APOBEC3G is a single-stranded DNA cytidine deaminase and functions independently of HIV reverse transcriptase

Death and the retrovirus

Network analysis of human and simian immunodeficiency virus sequence sets reveals massive recombination resulting in shorter pathways

Identification of a hepatitis B virus genome in wild chimpanzees (Pan troglodytes schweinfurthi) from East Africa indicates a wide geographical dispersion among equatorial African primates

Analysis of a library of macaque nuclear mitochondrial sequences confirms macaque origin of divergent sequences from old oral polio vaccine samples

Sustained G–>A hypermutation during reverse transcription of an entire human immunodeficiency virus type 1 strain Vau group O genome