Timeline

Lars Rogge

Head of Structure

14 Feb 2022

publication

Characterization of Blood Mucosal Associated Invariant T (MAIT) cells in Axial Spondyloarthritis and of resident MAITs from control axial enthesis.

16 Dec 2021

project

SpA23 – Rôle de l’IL-23 dans les maladies chroniques inflammatoires : exploration des mécanismes cellulaires et moléculaires de la signalisation de l’IL-23 dans la spondylarthrite axiale et périphérique

16 Jul 2021

project

Pso23 – Exploration des mécanismes cellulaires et moléculaires de la réponse chez les patients recevant une biothérapie ciblant l’axe IL-23/IL-17 dans le psoriasis cutané

01 Apr 2021

publication

Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo.

01 Apr 2021

publication

Novel approaches to develop biomarkers predicting treatment responses to TNF-blockers.

01 Jan 2021

publication

Editorial: Role of the IL-23/IL-17 Pathway in Chronic Immune-Mediated Inflammatory Diseases: Mechanisms and Targeted Therapies.

25 Aug 2020

publication

Cellular and molecular profiling of T-cell subsets at the onset of human acute GVHD.

13 Dec 2019

publication

Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites.

19 Mar 2019

publication

Anti-TNF Therapy in Spondyloarthritis and Related Diseases, Impact on the Immune System and Prediction of Treatment Responses

17 Oct 2018

publication

Brief Report: Interleukin-17 Blockade With Secukinumab in Peripheral Spondyloarthritis Impacts Synovial Immunopathology Without Compromising Systemic Immune Responses

27 Sep 2018

publication

Expansion of Interleukin-22- and Granulocyte-Macrophage Colony-Stimulating Factor-Expressing, but Not Interleukin-17A-Expressing, Group 3 Innate Lymphoid Cells in the Inflamed Joints of Patients With Spondyloarthritis

01 Mar 2018

publication

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors.

24 Nov 2017

publication

Regulatory T cells control toxicity in a humanized model of IL-2 therapy

19 Mar 2017

news

‘ILC-poiesis’: A new model of human ILC differentiation

09 Mar 2017

publication

Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.

14 Mar 2016

publication

IL-12 drives functional plasticity of human group 2 innate lymphoid cells

28 Jul 2015

patent

Seronegative spondyloarthropathy diagnosis and treatment (WO/2015/010744)

28 Jul 2015

project

Exploring immunological mechanisms of graft-versus-host disease and of functional immune tolerance in patients after allogeneic hematopoietic stem cell transplantation

07 Jul 2015

project

Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease

07 Jul 2015

project

Epigenetic mechanisms controlling the stability and plasticity of CD4+ T cell subsets

06 Jul 2015

project

Linking genotype, cell function and pathology in inflammatory diseases

11 May 2015

team

Immunoregulation

01 Apr 2015

publication

Automated flow cytometric analysis across large numbers of samples and cell types.

01 Apr 2015

publication

Semi-automated and standardized cytometric procedures for multi-panel and multi-parametric whole blood immunophenotyping.

20 Mar 2014

publication

Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli.

01 Jul 2013

publication

Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease

01 Jun 2013

publication

Combinatorial control of Th17 and Th1 cell functions by genetic variations in genes associated with the interleukin-23 signaling pathway in spondyloarthritis

08 Apr 2011

publication

Proinflammatory environment dictates the IL-17-producing capacity of human invariant NKT cells

24 May 2010

publication

In vivo expansion of naive and activated CD4+CD25+FOXP3+ regulatory T cell populations in interleukin-2-treated HIV patients

08 Apr 2010

publication

The human COP9 signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP)-mediated degradation

15 Dec 2009

publication

Integration of distinct intracellular signaling pathways at distal regulatory elements directs T-bet expression in human CD4+ T cells

01 Jun 2009

publication

Genetic and epigenetic networks controlling T helper 1 cell differentiation

01 Nov 2008

publication

Jakmip1 is expressed upon T cell differentiation and has an inhibitory function in cytotoxic T lymphocytes

01 Oct 2007

publication

Long oligonucleotide microarrays for African green monkey gene expression profile analysis.

15 Feb 2007

publication

Chromatin remodeling by the SWI/SNF-like BAF complex and STAT4 activation synergistically induce IL-12Rbeta2 expression during human Th1 cell differentiation

01 Oct 2006

publication

A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127

30 Aug 2006

publication

The COP9 signalosome regulates Skp2 levels and proliferation of human cells

13 Jan 2004

publication

RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1

24 Jul 2003

publication

Gene profiling of lymphoma, myeloma, and AML

21 Jul 2003

publication

Dissecting oncogenes and tyrosine kinases in AML cells

18 Jul 2003

publication

Antileukemic activity of natural killer cells in allogeneic BMT

01 Jul 2003

publication

Increased expression of alpha(1,3)-fucosyltransferase-VII and P-selectin binding of synovial fluid T cells in juvenile idiopathic arthritis

15 Jan 2003

publication

Down-modulation of responses to type I IFN upon T cell activation

06 Jan 2003

publication

Gene profiling for defining targets for new therapeutics in autoimmune diseases

01 Dec 2002

publication

A genomic view of helper T cell subsets

01 May 2000

publication

Transcript imaging of the development of human T helper cells using oligonucleotide arrays

01 Apr 2000

publication

A little guide for advanced search:

Characterization of Blood Mucosal Associated Invariant T (MAIT) cells in Axial Spondyloarthritis and of resident MAITs from control axial enthesis.

SpA23 – Rôle de l’IL-23 dans les maladies chroniques inflammatoires : exploration des mécanismes cellulaires et moléculaires de la signalisation de l’IL-23 dans la spondylarthrite axiale et périphérique

Pso23 – Exploration des mécanismes cellulaires et moléculaires de la réponse chez les patients recevant une biothérapie ciblant l’axe IL-23/IL-17 dans le psoriasis cutané

Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo.

Novel approaches to develop biomarkers predicting treatment responses to TNF-blockers.

Editorial: Role of the IL-23/IL-17 Pathway in Chronic Immune-Mediated Inflammatory Diseases: Mechanisms and Targeted Therapies.

Cellular and molecular profiling of T-cell subsets at the onset of human acute GVHD.

Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites.

Anti-TNF Therapy in Spondyloarthritis and Related Diseases, Impact on the Immune System and Prediction of Treatment Responses

Brief Report: Interleukin-17 Blockade With Secukinumab in Peripheral Spondyloarthritis Impacts Synovial Immunopathology Without Compromising Systemic Immune Responses

Expansion of Interleukin-22- and Granulocyte-Macrophage Colony-Stimulating Factor-Expressing, but Not Interleukin-17A-Expressing, Group 3 Innate Lymphoid Cells in the Inflamed Joints of Patients With Spondyloarthritis

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors.

Regulatory T cells control toxicity in a humanized model of IL-2 therapy

‘ILC-poiesis’: A new model of human ILC differentiation

Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.

IL-12 drives functional plasticity of human group 2 innate lymphoid cells

Seronegative spondyloarthropathy diagnosis and treatment (WO/2015/010744)

Exploring immunological mechanisms of graft-versus-host disease and of functional immune tolerance in patients after allogeneic hematopoietic stem cell transplantation

Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease

Epigenetic mechanisms controlling the stability and plasticity of CD4+ T cell subsets

Linking genotype, cell function and pathology in inflammatory diseases

Immunoregulation

Automated flow cytometric analysis across large numbers of samples and cell types.

Semi-automated and standardized cytometric procedures for multi-panel and multi-parametric whole blood immunophenotyping.

Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli.

Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease

Combinatorial control of Th17 and Th1 cell functions by genetic variations in genes associated with the interleukin-23 signaling pathway in spondyloarthritis

Proinflammatory environment dictates the IL-17-producing capacity of human invariant NKT cells

In vivo expansion of naive and activated CD4+CD25+FOXP3+ regulatory T cell populations in interleukin-2-treated HIV patients

The human COP9 signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP)-mediated degradation

Integration of distinct intracellular signaling pathways at distal regulatory elements directs T-bet expression in human CD4+ T cells

Genetic and epigenetic networks controlling T helper 1 cell differentiation

Jakmip1 is expressed upon T cell differentiation and has an inhibitory function in cytotoxic T lymphocytes

Long oligonucleotide microarrays for African green monkey gene expression profile analysis.

Chromatin remodeling by the SWI/SNF-like BAF complex and STAT4 activation synergistically induce IL-12Rbeta2 expression during human Th1 cell differentiation

A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127

The COP9 signalosome regulates Skp2 levels and proliferation of human cells

RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1

Gene profiling of lymphoma, myeloma, and AML

Dissecting oncogenes and tyrosine kinases in AML cells

Antileukemic activity of natural killer cells in allogeneic BMT

Increased expression of alpha(1,3)-fucosyltransferase-VII and P-selectin binding of synovial fluid T cells in juvenile idiopathic arthritis

Down-modulation of responses to type I IFN upon T cell activation

Gene profiling for defining targets for new therapeutics in autoimmune diseases

A genomic view of helper T cell subsets

Transcript imaging of the development of human T helper cells using oligonucleotide arrays

Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity