Ligne de temps

Lars Rogge
Responsable de Structure
29 sept. 2023
event

Immunology Phd Thesis : Étude des conséquences fonctionnelles d’une mutation ponctuelle du gène EXTL3 : Rôle dans l’ossification enchondrale

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14 févr. 2022
publication

Characterization of Blood Mucosal Associated Invariant T (MAIT) cells in Axial Spondyloarthritis and of resident MAITs from control axial enthesis.

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16 déc. 2021
project

SpA23 – Rôle de l’IL-23 dans les maladies chroniques inflammatoires : exploration des mécanismes cellulaires et moléculaires de la signalisation de l’IL-23 dans la spondylarthrite axiale et périphérique

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16 juil. 2021
project

Pso23 – Exploration des mécanismes cellulaires et moléculaires de la réponse chez les patients recevant une biothérapie ciblant l’axe IL-23/IL-17 dans le psoriasis cutané

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01 avr. 2021
publication

Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo.

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01 avr. 2021
publication

Novel approaches to develop biomarkers predicting treatment responses to TNF-blockers.

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01 janv. 2021
publication

Editorial: Role of the IL-23/IL-17 Pathway in Chronic Immune-Mediated Inflammatory Diseases: Mechanisms and Targeted Therapies.

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25 août 2020
publication

Cellular and molecular profiling of T-cell subsets at the onset of human acute GVHD.

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13 déc. 2019
publication

Metabolomics analysis of human acute graft-versus-host disease reveals changes in host and microbiota-derived metabolites.

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19 mars 2019
publication

Anti-TNF Therapy in Spondyloarthritis and Related Diseases, Impact on the Immune System and Prediction of Treatment Responses

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17 oct. 2018
publication

Brief Report: Interleukin-17 Blockade With Secukinumab in Peripheral Spondyloarthritis Impacts Synovial Immunopathology Without Compromising Systemic Immune Responses

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27 sept. 2018
publication

Expansion of Interleukin-22- and Granulocyte-Macrophage Colony-Stimulating Factor-Expressing, but Not Interleukin-17A-Expressing, Group 3 Innate Lymphoid Cells in the Inflamed Joints of Patients With Spondyloarthritis

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01 mars 2018
publication

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors.

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24 nov. 2017
publication

Regulatory T cells control toxicity in a humanized model of IL-2 therapy

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19 mars 2017
news

‘ILC-poiesis’: A new model of human ILC differentiation

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09 mars 2017
publication

Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.

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14 mars 2016
publication

IL-12 drives functional plasticity of human group 2 innate lymphoid cells

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28 juil. 2015
patent

Seronegative spondyloarthropathy diagnosis and treatment (WO/2015/010744)

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28 juil. 2015
project

Exploring immunological mechanisms of graft-versus-host disease and of functional immune tolerance in patients after allogeneic hematopoietic stem cell transplantation

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07 juil. 2015
project

Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease

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07 juil. 2015
project

Epigenetic mechanisms controlling the stability and plasticity of CD4+ T cell subsets

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06 juil. 2015
project

Linking genotype, cell function and pathology in inflammatory diseases

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11 mai 2015
team

Immunorégulation

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01 avr. 2015
publication

Semi-automated and standardized cytometric procedures for multi-panel and multi-parametric whole blood immunophenotyping.

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01 avr. 2015
publication

Automated flow cytometric analysis across large numbers of samples and cell types.

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20 mars 2014
publication

Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli.

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01 juil. 2013
publication

Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease

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01 juin 2013
publication

Combinatorial control of Th17 and Th1 cell functions by genetic variations in genes associated with the interleukin-23 signaling pathway in spondyloarthritis

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08 avr. 2011
publication

Proinflammatory environment dictates the IL-17-producing capacity of human invariant NKT cells

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24 mai 2010
publication

In vivo expansion of naive and activated CD4+CD25+FOXP3+ regulatory T cell populations in interleukin-2-treated HIV patients

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08 avr. 2010
publication

The human COP9 signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP)-mediated degradation

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15 déc. 2009
publication

Integration of distinct intracellular signaling pathways at distal regulatory elements directs T-bet expression in human CD4+ T cells

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01 juin 2009
publication

Genetic and epigenetic networks controlling T helper 1 cell differentiation

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01 nov. 2008
publication

Jakmip1 is expressed upon T cell differentiation and has an inhibitory function in cytotoxic T lymphocytes

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01 oct. 2007
publication

Long oligonucleotide microarrays for African green monkey gene expression profile analysis.

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15 févr. 2007
publication

Chromatin remodeling by the SWI/SNF-like BAF complex and STAT4 activation synergistically induce IL-12Rbeta2 expression during human Th1 cell differentiation

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01 oct. 2006
publication

A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127

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30 août 2006
publication

The COP9 signalosome regulates Skp2 levels and proliferation of human cells

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13 janv. 2004
publication

RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1

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24 juil. 2003
publication

Gene profiling of lymphoma, myeloma, and AML

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21 juil. 2003
publication

Dissecting oncogenes and tyrosine kinases in AML cells

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18 juil. 2003
publication

Antileukemic activity of natural killer cells in allogeneic BMT

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01 juil. 2003
publication

Increased expression of alpha(1,3)-fucosyltransferase-VII and P-selectin binding of synovial fluid T cells in juvenile idiopathic arthritis

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15 janv. 2003
publication

Down-modulation of responses to type I IFN upon T cell activation

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06 janv. 2003
publication

Gene profiling for defining targets for new therapeutics in autoimmune diseases

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01 déc. 2002
publication

A genomic view of helper T cell subsets

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01 mai 2000
publication

Transcript imaging of the development of human T helper cells using oligonucleotide arrays

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01 avr. 2000
publication

Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity

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