Timeline

Alain Jacquier

Head of Structure

06 Dec 2021

news

Congratulation to Alain Jacquier for receiving the Prix André Goffeau – 2021 Medal of the Société Française de Génétique

22 Oct 2021

news

Back on: Science Outreach during the Departmental retreat in Pornichet 2021

24 Sep 2021

news

Highlighted Publication : “Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast”, Decourty, L et al., NAR, 2021 Sep 7;49(15) – Genetics of Macromolecular Interactions team

07 Sep 2021

publication

Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast.

05 Oct 2020

publication

Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast

31 Jan 2020

project

Translation and Ribosome rescue

07 Jun 2019

publication

A specialised SKI complex assists the cytoplasmic RNA exosome in the absence of direct association with ribosomes

25 Mar 2019

publication

Structure of the 80S ribosome-Xrn1 nuclease complex

01 Oct 2018

publication

Nonsense-mediated mRNA decay involves two distinct Upf1-bound complexes

18 May 2018

publication

Antisense transcriptional interference mediates condition-specific gene repression in budding yeast

17 Mar 2017

publication

Exposure to selenomethionine causes selenocysteine misincorporation and protein aggregation in Saccharomyces cerevisiae

15 Mar 2017

publication

The ribosome-bound quality control complex remains associated to aberrant peptides during their proteasomal targeting and interacts with Tom1 to limit protein aggregation

16 Dec 2016

publication

The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex

13 Sep 2016

event

The zinc cluster proteins: a fungal family of transcriptional regulators with functions ranging from carbon metabolism to drug resistance

27 Apr 2016

publication

How cells kill a “killer” messenger

18 Apr 2016

publication

Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits

09 Jun 2015

project

Diversity and stability of eukaryotic transcripts

23 Apr 2015

publication

Quality control of transcription start site selection by nonsense-mediated-mRNA decay

09 Feb 2015

project

Genome-wide genetic screens by GIM (Genetic Interactions Mapping)

13 Feb 2014

publication

Long open reading frame transcripts escape nonsense-mediated mRNA decay in yeast

21 Nov 2013

publication

Dealing with pervasive transcription

13 Aug 2013

publication

Yeast ribosomal protein L7 and its homologue Rlp7 are simultaneously present at distinct sites on pre-60S ribosomal particles

11 Mar 2013

publication

Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products

20 Sep 2012

publication

Extensive degradation of RNA precursors by the exosome in wild-type cells

07 May 2012

publication

Sodium selenide toxicity is mediated by O2-dependent DNA breaks

13 Apr 2012

publication

The yeast RPL9B gene is regulated by modulation between two modes of transcription termination

01 Apr 2011

publication

Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs

01 Jan 2011

publication

Enrichment of unstable non-coding RNAs and their genome-wide identification

26 Mar 2010

publication

Ecm1 is a new pre-ribosomal factor involved in pre-60S particle export

01 Dec 2009

publication

The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs

18 Nov 2009

publication

Interaction of yeast eIF4G with spliceosome components: implications in pre-mRNA processing events

23 Oct 2009

publication

Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome

26 Mar 2009

publication

Cordycepin interferes with 3′ end formation in yeast independently of its potential to terminate RNA chain elongation

25 Jan 2009

publication

Widespread bidirectional promoters are the major source of cryptic transcripts in yeast

01 Sep 2008

publication

Futile cycle of transcription initiation and termination modulates the response to nucleotide shortage in S. cerevisiae

25 Jul 2008

publication

60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes

30 Jun 2008

publication

A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts

11 Apr 2008

publication

Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profiles

17 Sep 2007

publication

Hmo1 is required for TOR-dependent regulation of ribosomal protein gene transcription

24 Jul 2007

publication

The Hsp40 chaperone Jjj1 is required for the nucleo-cytoplasmic recycling of preribosomal factors in Saccharomyces cerevisiae

23 Jul 2007

publication

Cytoplasmic recycling of 60S preribosomal factors depends on the AAA protein Drg1

01 Jun 2007

publication

Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism

16 Feb 2007

publication

The p21-activated protein kinase inhibitor Skb15 and its budding yeast homologue are 60S ribosome assembly factors

21 Jul 2006

publication

Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs

01 May 2006

publication

A functional network involved in the recycling of nucleocytoplasmic pre-60S factors

01 Jun 2005

publication

RNA degradation by the exosome is promoted by a nuclear polyadenylation complex

01 Jun 2005

publication

The complete set of H/ACA snoRNAs that guide rRNA pseudouridylations in Saccharomyces cerevisiae

01 Jun 2005

publication

Cryptic pol II transcripts are degraded by a nuclear quality control pathway involving a new poly(A) polymerase

27 Jan 2005

publication

Staphylococcus aureus RNAIII and the endoribonuclease III coordinately regulate spa gene expression

01 Jul 2004

publication

Targeted mRNA degradation by deadenylation-independent decapping

09 Feb 2004

publication

Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein

09 Jan 2004

publication

Nuclear retention of unspliced mRNAs in yeast is mediated by perinuclear Mlp1

01 Jul 2003

publication

A snoRNA that guides the two most conserved pseudouridine modifications within rRNA confers a growth advantage in yeast

01 Jul 2003

publication

Sequential protein association with nascent 60S ribosomal particles

01 Nov 2002

publication

Human L1 element target-primed reverse transcription in vitro

01 Mar 2002

publication

Nuclear architecture and spatial positioning help establish transcriptional states of telomeres in yeast

01 Mar 2002

publication

Spc24 interacts with Mps2 and is required for chromosome segregation, but is not implicated in spindle pole body duplication

15 Nov 2001

publication

Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps

14 Feb 2001

publication

A little guide for advanced search:

Congratulation to Alain Jacquier for receiving the Prix André Goffeau – 2021 Medal of the Société Française de Génétique

Back on: Science Outreach during the Departmental retreat in Pornichet 2021

Highlighted Publication : “Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast”, Decourty, L et al., NAR, 2021 Sep 7;49(15) – Genetics of Macromolecular Interactions team

Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast.

Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast

Translation and Ribosome rescue

A specialised SKI complex assists the cytoplasmic RNA exosome in the absence of direct association with ribosomes

Structure of the 80S ribosome-Xrn1 nuclease complex

Nonsense-mediated mRNA decay involves two distinct Upf1-bound complexes

Antisense transcriptional interference mediates condition-specific gene repression in budding yeast

Exposure to selenomethionine causes selenocysteine misincorporation and protein aggregation in Saccharomyces cerevisiae

The ribosome-bound quality control complex remains associated to aberrant peptides during their proteasomal targeting and interacts with Tom1 to limit protein aggregation

The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex

The zinc cluster proteins: a fungal family of transcriptional regulators with functions ranging from carbon metabolism to drug resistance

How cells kill a “killer” messenger

Rqc1 and Ltn1 Prevent C-terminal Alanine-Threonine Tail (CAT-tail)-induced Protein Aggregation by Efficient Recruitment of Cdc48 on Stalled 60S Subunits

Diversity and stability of eukaryotic transcripts

Quality control of transcription start site selection by nonsense-mediated-mRNA decay

Genome-wide genetic screens by GIM (Genetic Interactions Mapping)

Long open reading frame transcripts escape nonsense-mediated mRNA decay in yeast

Dealing with pervasive transcription

Yeast ribosomal protein L7 and its homologue Rlp7 are simultaneously present at distinct sites on pre-60S ribosomal particles

Cdc48-associated complex bound to 60S particles is required for the clearance of aberrant translation products

Extensive degradation of RNA precursors by the exosome in wild-type cells

Sodium selenide toxicity is mediated by O2-dependent DNA breaks

The yeast RPL9B gene is regulated by modulation between two modes of transcription termination

Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs

Enrichment of unstable non-coding RNAs and their genome-wide identification

Ecm1 is a new pre-ribosomal factor involved in pre-60S particle export

The complex eukaryotic transcriptome: unexpected pervasive transcription and novel small RNAs

Interaction of yeast eIF4G with spliceosome components: implications in pre-mRNA processing events

Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome

Cordycepin interferes with 3′ end formation in yeast independently of its potential to terminate RNA chain elongation

Widespread bidirectional promoters are the major source of cryptic transcripts in yeast

Futile cycle of transcription initiation and termination modulates the response to nucleotide shortage in S. cerevisiae

60S ribosomal subunit assembly dynamics defined by semi-quantitative mass spectrometry of purified complexes

A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts

Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profiles

Hmo1 is required for TOR-dependent regulation of ribosomal protein gene transcription

The Hsp40 chaperone Jjj1 is required for the nucleo-cytoplasmic recycling of preribosomal factors in Saccharomyces cerevisiae

Cytoplasmic recycling of 60S preribosomal factors depends on the AAA protein Drg1

Staphylococcus aureus RNAIII coordinately represses the synthesis of virulence factors and the transcription regulator Rot by an antisense mechanism

The p21-activated protein kinase inhibitor Skb15 and its budding yeast homologue are 60S ribosome assembly factors

Nsa2 is an unstable, conserved factor required for the maturation of 27 SB pre-rRNAs

A functional network involved in the recycling of nucleocytoplasmic pre-60S factors

RNA degradation by the exosome is promoted by a nuclear polyadenylation complex

The complete set of H/ACA snoRNAs that guide rRNA pseudouridylations in Saccharomyces cerevisiae

Cryptic pol II transcripts are degraded by a nuclear quality control pathway involving a new poly(A) polymerase

Staphylococcus aureus RNAIII and the endoribonuclease III coordinately regulate spa gene expression

Targeted mRNA degradation by deadenylation-independent decapping

Identification of TINO: a new evolutionarily conserved BCL-2 AU-rich element RNA-binding protein

Nuclear retention of unspliced mRNAs in yeast is mediated by perinuclear Mlp1

A snoRNA that guides the two most conserved pseudouridine modifications within rRNA confers a growth advantage in yeast

Sequential protein association with nascent 60S ribosomal particles

Human L1 element target-primed reverse transcription in vitro

Nuclear architecture and spatial positioning help establish transcriptional states of telomeres in yeast

Spc24 interacts with Mps2 and is required for chromosome segregation, but is not implicated in spindle pole body duplication

Nog2p, a putative GTPase associated with pre-60S subunits and required for late 60S maturation steps

Identification of 12 new yeast mitochondrial ribosomal proteins including 6 that have no prokaryotic homologues