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© Research
Event

The zinc cluster proteins: a fungal family of transcriptional regulators with functions ranging from carbon metabolism to drug resistance

Scientific Fields
Diseases
Organisms
Applications
Technique
Date
15
Sep 2016
Time
11:00:00
25-28 Rue du Docteur Roux, Paris, France
Address
Building: Jacques Monod
Location
2016-09-15 11:00:00 2016-09-15 00:00:00 Europe/Paris The zinc cluster proteins: a fungal family of transcriptional regulators with functions ranging from carbon metabolism to drug resistance Bernard TURCOTTE Dept of Medicine, McGill University Health Center, Montréal Québec (en année sabbatique dans l’Unité Génétique des Interactions Macromoléculaires) Abstract: Research in my lab focuses on a family of transcriptional regulators that are […] 25-28 Rue du Docteur Roux, Paris, France Alain Jacquier alain.jacquier@pasteur.fr

About

Bernard TURCOTTE
Dept of Medicine, McGill University Health Center, Montréal Québec
(en année sabbatique dans l’Unité Génétique des Interactions Macromoléculaires)

Abstract:
Research in my lab focuses on a family of transcriptional regulators that are called zinc cluster proteins. Members of this family are only found in fungi (or amoeba) and possess the well-conserved motif CysX2CysX6CysX5-12CysX2CysX6-8Cys. The cysteine residues bind to two zinc atoms, which coordinate folding of the domain involved in DNA recogition. The best known member of this family is probably Gal4, a transcriptional activator involved in galactose metabolism in budding yeast (Saccharomyces cerevisiae). Zinc cluster proteins function in a wide range of processes including metabolism, stress response, meiosis, and drug resistance. In budding yeast, we have characterized a number of zinc cluster proteins that are involved in controlling non fermentable carbon utilization through a complex regulatory network. More recently, we have extended our studies of this family of transcription factors to Candida glabrata, an important human fungal pathogen. Results show that a number of zinc cluster proteins modulate drug resistance in this pathogen

Location

Building: Jacques Monod
Address: 25-28 Rue du Docteur Roux, Paris, France