Timeline

Bruno Blondel

Retired scientist

08 Jan 2024

event

Club viro: SARS-CoV2 RBD-Specific Antibodies /// APOBEC3F & Monkeypox virus

08 Sep 2023

event

Club viro: Influenza A virus & TDP-43 /// SARS-CoV-2-mediated cell hijacking

14 Sep 2019

publication

Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process

02 Jan 2019

publication

High permissiveness for genetic exchanges between enteroviruses of species A, including enterovirus 71, favours evolution through intertypic recombination in Madagascar

22 Dec 2018

publication

Nomenclature et classification des entérovirus : quelle histoire !

03 Apr 2018

event

Club viro : 1- Virus d’archaebactéries ; 2- Interférence ARN.

07 Jun 2017

event

Club viro solsticial

17 May 2017

event

Club viro, 31 mai 2017

03 May 2017

event

Club viro, spécial Groupe à 5 ans Interactions virus-insectes (département Génomes et génétique)

18 Apr 2017

event

Club viro du 3 mai 2017

05 Apr 2017

event

Club viro

04 Apr 2017

event

Club-viro

13 Dec 2016

publication

Exchanges of genomic domains between poliovirus and other cocirculating species C enteroviruses reveal a high degree of plasticity

12 Jul 2016

publication

The CREB3-Herp signaling module limits the cytosolic calcium concentration increase and apoptosis induced by poliovirus

11 Sep 2015

project

EV-A71 study

03 Jul 2015

project

Studies of cVDPVs

05 Aug 2014

publication

Nonhomologous recombination between defective poliovirus and coxsackievirus genomes suggests a new model of genetic plasticity for picornaviruses

20 Nov 2013

publication

[Eradication of poliomyelitis and emergence of pathogenic vaccine-derived polioviruses: from Madagascar to Cameroon]

07 Aug 2013

publication

The Golgi protein ACBD3, an interactor for poliovirus protein 3A, modulates poliovirus replication

22 Sep 2010

publication

Calcium flux between the endoplasmic reticulum and mitochondrion contributes to poliovirus-induced apoptosis

14 Apr 2010

publication

Enhanced gene silencing in cells cured of persistent virus infection by RNA interference

01 Jan 2009

publication

Apoptotic signaling cascades operating in poliovirus-infected cells

01 Apr 2008

publication

[Genetic evolution of poliovirus: success and difficulties in the eradication of paralytic poliomyelitis]

23 Jan 2008

publication

Early phosphatidylinositol 3-kinase/Akt pathway activation limits poliovirus-induced JNK-mediated cell death

01 Dec 2007

publication

Co-circulation and evolution of polioviruses and species C enteroviruses in a district of Madagascar

02 Oct 2007

publication

Prevention and treatment of enteric viral infections: possible benefits of probiotic bacteria

09 May 2007

publication

Poliovirus induces Bax-dependent cell death mediated by c-Jun NH2-terminal kinase

14 Feb 2007

publication

Bax is activated during rotavirus-induced apoptosis through the mitochondrial pathway

01 Sep 2006

publication

Cross talk between PML and p53 during poliovirus infection: implications for antiviral defense

13 Mar 2005

publication

Silencing viruses by RNA interference

01 Jan 2005

publication

Poliovirus, pathogenesis of poliomyelitis, and apoptosis

01 Jan 2004

publication

Poliovirus and apoptosis

01 Jan 2003

publication

Poliovirus-induced apoptosis is reduced in cells expressing a mutant CD155 selected during persistent poliovirus infection in neuroblastoma cells

01 Aug 2002

publication

An ex vivo murine model to study poliovirus-induced apoptosis in nerve cells

01 May 2002

publication

Restriction of poliovirus RNA replication in persistently infected nerve cells

01 Jan 2001

publication

Poliovirus persistence in human cells in vitro

01 Jan 2001

publication

Inhibition of poliovirus RNA synthesis as a molecular mechanism contributing to viral persistence in the mouse central nervous system

01 Sep 2000

publication

Expression of mutated poliovirus receptors in human neuroblastoma cells persistently infected with poliovirus

01 Jul 1999

publication

Poliovirus induces apoptosis in the mouse central nervous system

01 Feb 1998

publication

Molecular aspects of poliovirus biology with a special focus on the interactions with nerve cells

01 Feb 1997

publication

Persistent poliovirus infection in mouse motoneurons

01 Jan 1996

publication

Mouse adaptation determinants of poliovirus type 1 enhance viral uncoating

01 Oct 1995

publication

Cell clones cured of persistent poliovirus infection display selective permissivity to the wild-type poliovirus strain Mahoney and partial resistance to the attenuated Sabin 1 strain and Mahoney mutants

25 May 1995

publication

Persistent poliovirus infection: development of new models with cell lines

01 Dec 1994

publication

Substitutions in the capsids of poliovirus mutants selected in human neuroblastoma cells confer on the Mahoney type 1 strain a phenotype neurovirulent in mice

01 Aug 1993

publication

A mutation in the RNA polymerase of poliovirus type 1 contributes to attenuation in mice

01 Jul 1993

publication

Molecular characterization of mouse-virulent poliovirus type 1 Mahoney mutants: involvement of residues of polypeptides VP1 and VP2 located on the inner surface of the capsid protein shell

01 Apr 1992

publication

Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells

01 Dec 1990

publication

Structural factors modulate the activity of antigenic poliovirus sequences expressed on hybrid hepatitis B surface antigen particles

01 Nov 1990

publication

Stromal influences on transformation of human mammary epithelial cells overexpressing c-myc and SV40T

01 Oct 1990

publication

The mouse int-2 gene exhibits basic fibroblast growth factor activity in a basic fibroblast growth factor-responsive cell line

01 Jun 1990

publication

Efficient induction of focus formation in a subclone of NIH3T3 cells by c-myc and its inhibition by serum and by growth factors

01 Aug 1988

publication

Construction and characterization of hybrid hepatitis B antigen particles carrying a poliovirus immunogen

01 May 1988

publication

Presentation and immunogenicity of the hepatitis B surface antigen and a poliovirus neutralization antigen on mixed empty envelope particles

01 Jan 1987

publication

Present knowledge of poliovirus and perspectives for future vaccines

01 Jan 1987

publication

Identification and characterization of a continuous neutralization epitope (C3) present on type 1 poliovirus

25 Jul 1986

publication

A poliovirus neutralization epitope expressed on hybrid hepatitis B surface antigen particles

01 Jan 1986

publication

Mutations conferring resistance to neutralization with monoclonal antibodies in type 1 poliovirus can be located outside or inside the antibody-binding site

01 Jan 1985

publication

Mapping of type 1 poliovirus neutralization epitopes

01 Jan 1985

publication

Antigenic modification of attenuated Sabin type 1 poliovirus by in vitro passages at supraoptimal temperatures

01 May 1984

publication

Antigenic variation of poliovirus studied by means of monoclonal antibodies

01 Jan 1984

publication

Neutralization epitope patterns of poliovirus strains isolated from paralytic cases

01 Sep 1983

publication

Natural variation of poliovirus neutralization epitopes

01 Aug 1983

publication

Localization of a poliovirus type 1 neutralization epitope in viral capsid polypeptide VP1

30 Apr 1983

publication

Detection by monoclonal antibodies of an antigenic determinant critical for poliovirus neutralization present on VP1 and on heat-inactivated virions

01 Jan 1983

publication

Induction of neutralizing antibodies by type 1 poliovirus VP1 capsid polypeptide

01 Dec 1982

publication

Evidence for common, intertypic antigenic determinants on poliovirus capsid polypeptides

11 Jan 1982

publication

[Structural polypeptide VP1 in poliovirus type 1 induced by neutralizing antibodies]

01 Jan 1981

publication

A little guide for advanced search:

Club viro: SARS-CoV2 RBD-Specific Antibodies /// APOBEC3F & Monkeypox virus

Club viro: Influenza A virus & TDP-43 /// SARS-CoV-2-mediated cell hijacking

Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process

High permissiveness for genetic exchanges between enteroviruses of species A, including enterovirus 71, favours evolution through intertypic recombination in Madagascar

Nomenclature et classification des entérovirus : quelle histoire !

Club viro : 1- Virus d’archaebactéries ; 2- Interférence ARN.

Club viro solsticial

Club viro, 31 mai 2017

Club viro, spécial Groupe à 5 ans Interactions virus-insectes (département Génomes et génétique)

Club viro du 3 mai 2017

Club viro

Club-viro

Exchanges of genomic domains between poliovirus and other cocirculating species C enteroviruses reveal a high degree of plasticity

The CREB3-Herp signaling module limits the cytosolic calcium concentration increase and apoptosis induced by poliovirus

EV-A71 study

Studies of cVDPVs

Nonhomologous recombination between defective poliovirus and coxsackievirus genomes suggests a new model of genetic plasticity for picornaviruses

[Eradication of poliomyelitis and emergence of pathogenic vaccine-derived polioviruses: from Madagascar to Cameroon]

The Golgi protein ACBD3, an interactor for poliovirus protein 3A, modulates poliovirus replication

Calcium flux between the endoplasmic reticulum and mitochondrion contributes to poliovirus-induced apoptosis

Enhanced gene silencing in cells cured of persistent virus infection by RNA interference

Apoptotic signaling cascades operating in poliovirus-infected cells

[Genetic evolution of poliovirus: success and difficulties in the eradication of paralytic poliomyelitis]

Early phosphatidylinositol 3-kinase/Akt pathway activation limits poliovirus-induced JNK-mediated cell death

Co-circulation and evolution of polioviruses and species C enteroviruses in a district of Madagascar

Prevention and treatment of enteric viral infections: possible benefits of probiotic bacteria

Poliovirus induces Bax-dependent cell death mediated by c-Jun NH2-terminal kinase

Bax is activated during rotavirus-induced apoptosis through the mitochondrial pathway

Cross talk between PML and p53 during poliovirus infection: implications for antiviral defense

Silencing viruses by RNA interference

Poliovirus, pathogenesis of poliomyelitis, and apoptosis

Poliovirus and apoptosis

Poliovirus-induced apoptosis is reduced in cells expressing a mutant CD155 selected during persistent poliovirus infection in neuroblastoma cells

An ex vivo murine model to study poliovirus-induced apoptosis in nerve cells

Restriction of poliovirus RNA replication in persistently infected nerve cells

Poliovirus persistence in human cells in vitro

Inhibition of poliovirus RNA synthesis as a molecular mechanism contributing to viral persistence in the mouse central nervous system

Expression of mutated poliovirus receptors in human neuroblastoma cells persistently infected with poliovirus

Poliovirus induces apoptosis in the mouse central nervous system

Molecular aspects of poliovirus biology with a special focus on the interactions with nerve cells

Persistent poliovirus infection in mouse motoneurons

Mouse adaptation determinants of poliovirus type 1 enhance viral uncoating

Cell clones cured of persistent poliovirus infection display selective permissivity to the wild-type poliovirus strain Mahoney and partial resistance to the attenuated Sabin 1 strain and Mahoney mutants

Persistent poliovirus infection: development of new models with cell lines

Substitutions in the capsids of poliovirus mutants selected in human neuroblastoma cells confer on the Mahoney type 1 strain a phenotype neurovirulent in mice

A mutation in the RNA polymerase of poliovirus type 1 contributes to attenuation in mice

Molecular characterization of mouse-virulent poliovirus type 1 Mahoney mutants: involvement of residues of polypeptides VP1 and VP2 located on the inner surface of the capsid protein shell

Mouse mammary tumor gene int-3: a member of the notch gene family transforms mammary epithelial cells

Structural factors modulate the activity of antigenic poliovirus sequences expressed on hybrid hepatitis B surface antigen particles

Stromal influences on transformation of human mammary epithelial cells overexpressing c-myc and SV40T

The mouse int-2 gene exhibits basic fibroblast growth factor activity in a basic fibroblast growth factor-responsive cell line

Efficient induction of focus formation in a subclone of NIH3T3 cells by c-myc and its inhibition by serum and by growth factors

Construction and characterization of hybrid hepatitis B antigen particles carrying a poliovirus immunogen

Presentation and immunogenicity of the hepatitis B surface antigen and a poliovirus neutralization antigen on mixed empty envelope particles

Present knowledge of poliovirus and perspectives for future vaccines

Identification and characterization of a continuous neutralization epitope (C3) present on type 1 poliovirus

A poliovirus neutralization epitope expressed on hybrid hepatitis B surface antigen particles

Mutations conferring resistance to neutralization with monoclonal antibodies in type 1 poliovirus can be located outside or inside the antibody-binding site

Mapping of type 1 poliovirus neutralization epitopes

Antigenic modification of attenuated Sabin type 1 poliovirus by in vitro passages at supraoptimal temperatures

Antigenic variation of poliovirus studied by means of monoclonal antibodies

Neutralization epitope patterns of poliovirus strains isolated from paralytic cases

Natural variation of poliovirus neutralization epitopes

Localization of a poliovirus type 1 neutralization epitope in viral capsid polypeptide VP1

Detection by monoclonal antibodies of an antigenic determinant critical for poliovirus neutralization present on VP1 and on heat-inactivated virions

Induction of neutralizing antibodies by type 1 poliovirus VP1 capsid polypeptide

Evidence for common, intertypic antigenic determinants on poliovirus capsid polypeptides

[Structural polypeptide VP1 in poliovirus type 1 induced by neutralizing antibodies]

A technique to detect the reaction between poliovirus structural polypeptides and neutralizing anti-polio IgG