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© Research
Publication : Journal of virology

Calcium flux between the endoplasmic reticulum and mitochondrion contributes to poliovirus-induced apoptosis

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of virology - 22 Sep 2010

Brisac C, Téoulé F, Autret A, Pelletier I, Colbère-Garapin F, Brenner C, Lemaire C, Blondel B

Link to Pubmed [PMID] – 20861253

J. Virol. 2010 Dec;84(23):12226-35

We show that poliovirus (PV) infection induces an increase in cytosolic calcium (Ca(2+)) concentration in neuroblastoma IMR5 cells, at least partly through Ca(2+) release from the endoplasmic reticulum lumen via the inositol 1,4,5-triphosphate receptor (IP(3)R) and ryanodine receptor (RyR) channels. This leads to Ca(2+) accumulation in mitochondria through the mitochondrial Ca(2+) uniporter and the voltage-dependent anion channel (VDAC). This increase in mitochondrial Ca(2+) concentration in PV-infected cells leads to mitochondrial dysfunction and apoptosis.

http://www.ncbi.nlm.nih.gov/pubmed/20861253