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© Research
Publication : Developments in biological standardization

Induction of neutralizing antibodies by type 1 poliovirus VP1 capsid polypeptide

Team: Archived: Biology of Enteric Viruses
Member: Bruno Blondel
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Developments in biological standardization - 01 Jan 1983

Crainic R, Blondel B, Horaud F

Link to Pubmed [PMID] – 6329856

Dev. Biol. Stand. 1983;55:185-9

Sera against purified VP1, VP2, and VP3 poliovirus capsid polypeptides of type 1 poliovirus were prepared in rabbits. Each serum was demonstrated to be specific for the polypeptide against which it was raised by immunoprecipitation with labeled, individualized capsid polypeptides. One of the anti-VP1 sera had a neutralizing capacity against type 1 poliovirus. It was the only one which reacted in immunoprecipitation with D-antigenic infectious particles.