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© Research
Publication : Journal of virology

Early phosphatidylinositol 3-kinase/Akt pathway activation limits poliovirus-induced JNK-mediated cell death

Team: Archived: Biology of Enteric Viruses
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of virology - 23 Jan 2008

Autret A, Martin-Latil S, Brisac C, Mousson L, Colbère-Garapin F, Blondel B

Link to Pubmed [PMID] – 18216097

J. Virol. 2008 Apr;82(7):3796-802

Poliovirus (PV)-induced apoptosis seems to play a major role in tissue injury in the central nervous system (CNS). We have previously shown that this process involves PV-induced Bax-dependent mitochondrial dysfunction mediated by early JNK activation in IMR5 neuroblastoma cells. We showed here that PV simultaneously activates the phosphatidylinositol 3-kinase (PI3K)/Akt survival signaling pathway in these cells, limiting the extent of JNK activation and thereby cell death. JNK inhibition is associated with PI3K-dependent negative regulation of the apoptosis signal-regulating kinase 1, which acts upstream from JNK in PV-infected IMR5 cells. In poliomyelitis, this survival pathway may limit the spread of PV-induced damage in the CNS.