Timeline

Sébastien Brier

Research Engineer

02 Feb 2023

publication

Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.

01 Feb 2023

news

Bacterial pathogenicity: improving understanding of an essential process – molecule secretion

11 Sep 2022

project

Energir: Energy dependent iron import by Gram-negative bacteria

09 Aug 2022

publication

Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.

16 Mar 2022

event

Half-day Latest innovations and Applications in CryoEM& CryoET

01 Jan 2022

publication

Development of a highly specific and sensitive VHH-based sandwich immunoassay for the detection of the SARS-CoV-2 nucleoprotein.

01 May 2021

publication

Characterization of a highly neutralizing single monoclonal antibody to botulinum neurotoxin type A.

01 May 2021

publication

A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.

01 Jan 2020

publication

Hydrogen/Deuterium Exchange Mass Spectrometry for the Structural Analysis of Detergent-Solubilized Membrane Proteins.

27 Jun 2019

publication

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

21 Jun 2019

publication

Post-translational acylation controls the folding and functions of the CyaA RTX toxin.

23 May 2019

publication

Dynamics of a type 2 secretion system pseudopilus unraveled by complementary approaches

01 Nov 2018

publication

Translocation and calmodulin-activation of the adenylate cyclase toxin (CyaA) of Bordetella pertussis.

28 Jun 2018

team

Biological NMR and HDX-MS Technological Platform

24 Nov 2017

publication

Characterization of epitope specificities of reference antibodies used for the quantification of the birch pollen allergen Bet v 1

14 Nov 2017

publication

Structural disorder and induced folding within two cereal, ABA stress and ripening (ASR) proteins

28 Sep 2017

publication

Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem

21 May 2017

publication

Prepore Stability Controls Productive Folding of the BAM-independent Multimeric Outer Membrane Secretin PulD.

19 Apr 2017

publication

Structure and allosteric inhibition of excitatory amino acid transporter 1

27 Jan 2017

event

HDX-MS/NMR DAY

06 Jan 2017

publication

Prepore Stability Controls Productive Folding of the BAM-independent Multimeric Outer Membrane Secretin PulD.

01 Jan 2017

publication

Calmodulin fishing with a structurally disordered bait triggers CyaA catalysis.

01 Sep 2016

publication

Proteomics for Allergy: from Proteins to the Patients

13 Jul 2016

publication

MEMHDX: an interactive tool to expedite the statistical validation and visualization of large HDX-MS datasets.

23 Jun 2016

software

MEMHDX – Mixed Effects Models for HDX experiments

22 Apr 2016

publication

Molecular Basis of Ligand-Dependent Regulation of NadR, the Transcriptional Repressor of Meningococcal Virulence Factor NadA

18 Nov 2015

project

Molecular crowding

16 Sep 2015

publication

Structural models of intrinsically disordered and calcium-bound folded states of a protein adapted for secretion.

17 Aug 2015

project

CyaA secretion, folding and translocation across membrane

21 Jul 2015

project

Development of a new statistical tool for the analysis of large HDX-MS data sets

07 Jul 2015

project

Bacterial Transmembrane Signaling

11 May 2015

team

Mass Spectrometry for Biology

20 Feb 2015

publication

Neisseria meningitis GNA1030 is a ubiquinone-8 binding protein

26 Dec 2013

publication

Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties

08 Feb 2013

publication

Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen

10 Dec 2012

publication

Transcriptional regulation of the nadA gene in Neisseria meningitidis impacts the prediction of coverage of a multicomponent meningococcal serogroup B vaccine

15 Aug 2012

publication

Structural insight into the mechanism of DNA-binding attenuation of the Neisserial adhesin repressor NadR by the small natural ligand 4-hydroxyphenylacetic acid

30 Jun 2010

publication

Mapping surface accessibility of the C1r/C1s tetramer by chemical modification and mass spectrometry provides new insights into assembly of the human C1 complex

01 Apr 2009

publication

Aspartic proteinases in Antarctic fish

01 Jan 2008

publication

Hydrogen exchange mass spectrometry: principles and capabilities

01 Nov 2007

publication

Purification and characterization of pepsins A1 and A2 from the Antarctic rock cod Trematomus bernacchii

27 Feb 2007

publication

The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding

01 Dec 2006

publication

The marine natural product adociasulfate-2 as a tool to identify the MT-binding region of kinesins

15 May 2006

publication

Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents

01 Jan 2006

publication

Use of hydrogen/deuterium exchange mass spectrometry and mutagenesis as a tool to identify the binding region of inhibitors targeting the human mitotic kinesin Eg5

19 Oct 2004

publication

A little guide for advanced search:

Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.

Bacterial pathogenicity: improving understanding of an essential process – molecule secretion

Energir: Energy dependent iron import by Gram-negative bacteria

Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.

Half-day Latest innovations and Applications in CryoEM& CryoET

Development of a highly specific and sensitive VHH-based sandwich immunoassay for the detection of the SARS-CoV-2 nucleoprotein.

Characterization of a highly neutralizing single monoclonal antibody to botulinum neurotoxin type A.

A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.

Hydrogen/Deuterium Exchange Mass Spectrometry for the Structural Analysis of Detergent-Solubilized Membrane Proteins.

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

Post-translational acylation controls the folding and functions of the CyaA RTX toxin.

Dynamics of a type 2 secretion system pseudopilus unraveled by complementary approaches

Translocation and calmodulin-activation of the adenylate cyclase toxin (CyaA) of Bordetella pertussis.

Biological NMR and HDX-MS Technological Platform

Characterization of epitope specificities of reference antibodies used for the quantification of the birch pollen allergen Bet v 1

Structural disorder and induced folding within two cereal, ABA stress and ripening (ASR) proteins

Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem

Prepore Stability Controls Productive Folding of the BAM-independent Multimeric Outer Membrane Secretin PulD.

Structure and allosteric inhibition of excitatory amino acid transporter 1

HDX-MS/NMR DAY

Prepore Stability Controls Productive Folding of the BAM-independent Multimeric Outer Membrane Secretin PulD.

Calmodulin fishing with a structurally disordered bait triggers CyaA catalysis.

Proteomics for Allergy: from Proteins to the Patients

MEMHDX: an interactive tool to expedite the statistical validation and visualization of large HDX-MS datasets.

MEMHDX – Mixed Effects Models for HDX experiments

Molecular Basis of Ligand-Dependent Regulation of NadR, the Transcriptional Repressor of Meningococcal Virulence Factor NadA

Molecular crowding

Structural models of intrinsically disordered and calcium-bound folded states of a protein adapted for secretion.

CyaA secretion, folding and translocation across membrane

Development of a new statistical tool for the analysis of large HDX-MS data sets

Bacterial Transmembrane Signaling

Mass Spectrometry for Biology

Neisseria meningitis GNA1030 is a ubiquinone-8 binding protein

Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties

Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen

Transcriptional regulation of the nadA gene in Neisseria meningitidis impacts the prediction of coverage of a multicomponent meningococcal serogroup B vaccine

Structural insight into the mechanism of DNA-binding attenuation of the Neisserial adhesin repressor NadR by the small natural ligand 4-hydroxyphenylacetic acid

Mapping surface accessibility of the C1r/C1s tetramer by chemical modification and mass spectrometry provides new insights into assembly of the human C1 complex

Aspartic proteinases in Antarctic fish

Hydrogen exchange mass spectrometry: principles and capabilities

Purification and characterization of pepsins A1 and A2 from the Antarctic rock cod Trematomus bernacchii

The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding

The marine natural product adociasulfate-2 as a tool to identify the MT-binding region of kinesins

Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents

Use of hydrogen/deuterium exchange mass spectrometry and mutagenesis as a tool to identify the binding region of inhibitors targeting the human mitotic kinesin Eg5

Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5