Ligne de temps

Sébastien Brier
Ingénieur(e) de Recherche
02 févr. 2023
publication

Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system.

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01 févr. 2023
news

Bacterial pathogenicity: improving understanding of an essential process – molecule secretion

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11 sept. 2022
project

Energir: Comprendre les mécanismes moléculaires d’acquisition du fer chez les bactéries à Gram-négatif, par une approche intégrative

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09 août 2022
publication

Dynamics and structural changes of calmodulin upon interaction with the antagonist calmidazolium.

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16 mars 2022
event

Half-day Latest innovations and Applications in CryoEM& CryoET

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01 janv. 2022
publication

Development of a highly specific and sensitive VHH-based sandwich immunoassay for the detection of the SARS-CoV-2 nucleoprotein.

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01 mai 2021
publication

Characterization of a highly neutralizing single monoclonal antibody to botulinum neurotoxin type A.

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01 mai 2021
publication

A High-Affinity Calmodulin-Binding Site in the CyaA Toxin Translocation Domain is Essential for Invasion of Eukaryotic Cells.

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01 janv. 2020
publication

Hydrogen/Deuterium Exchange Mass Spectrometry for the Structural Analysis of Detergent-Solubilized Membrane Proteins.

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27 juin 2019
publication

Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments

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21 juin 2019
publication

Post-translational acylation controls the folding and functions of the CyaA RTX toxin.

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23 mai 2019
publication

Dynamics of a type 2 secretion system pseudopilus unraveled by complementary approaches

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01 nov. 2018
publication

Translocation and calmodulin-activation of the adenylate cyclase toxin (CyaA) of Bordetella pertussis.

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28 juin 2018
team

Plate-Forme Technologique de RMN Biologique et HDX-MS

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24 nov. 2017
publication

Characterization of epitope specificities of reference antibodies used for the quantification of the birch pollen allergen Bet v 1

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14 nov. 2017
publication

Structural disorder and induced folding within two cereal, ABA stress and ripening (ASR) proteins

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28 sept. 2017
publication

Structural Characterization of Whirlin Reveals an Unexpected and Dynamic Supramodule Conformation of Its PDZ Tandem

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21 mai 2017
publication

Prepore Stability Controls Productive Folding of the BAM-independent Multimeric Outer Membrane Secretin PulD.

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19 avr. 2017
publication

Structure and allosteric inhibition of excitatory amino acid transporter 1

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27 janv. 2017
event

HDX-MS/NMR DAY

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06 janv. 2017
publication

Prepore Stability Controls Productive Folding of the BAM-independent Multimeric Outer Membrane Secretin PulD.

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01 janv. 2017
publication

Calmodulin fishing with a structurally disordered bait triggers CyaA catalysis.

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01 sept. 2016
publication

Proteomics for Allergy: from Proteins to the Patients

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13 juil. 2016
publication

MEMHDX: an interactive tool to expedite the statistical validation and visualization of large HDX-MS datasets.

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23 juin 2016
software

MEMHDX – Mixed Effects Models for HDX experiments

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22 avr. 2016
publication

Molecular Basis of Ligand-Dependent Regulation of NadR, the Transcriptional Repressor of Meningococcal Virulence Factor NadA

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18 nov. 2015
project

Molecular crowding

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16 sept. 2015
publication

Structural models of intrinsically disordered and calcium-bound folded states of a protein adapted for secretion.

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17 août 2015
project

CyaA secretion, folding and translocation across membrane

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21 juil. 2015
project

Development of a new statistical tool for the analysis of large HDX-MS data sets

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07 juil. 2015
project

Bacterial Transmembrane Signaling

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11 mai 2015
team

Spectrométrie de Masse pour la Biologie (UTechS MSBio)

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20 févr. 2015
publication

Neisseria meningitis GNA1030 is a ubiquinone-8 binding protein

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26 déc. 2013
publication

Two cross-reactive monoclonal antibodies recognize overlapping epitopes on Neisseria meningitidis factor H binding protein but have different functional properties

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08 févr. 2013
publication

Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen

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10 déc. 2012
publication

Transcriptional regulation of the nadA gene in Neisseria meningitidis impacts the prediction of coverage of a multicomponent meningococcal serogroup B vaccine

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15 août 2012
publication

Structural insight into the mechanism of DNA-binding attenuation of the Neisserial adhesin repressor NadR by the small natural ligand 4-hydroxyphenylacetic acid

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30 juin 2010
publication

Mapping surface accessibility of the C1r/C1s tetramer by chemical modification and mass spectrometry provides new insights into assembly of the human C1 complex

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01 avr. 2009
publication

Aspartic proteinases in Antarctic fish

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01 janv. 2008
publication

Hydrogen exchange mass spectrometry: principles and capabilities

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01 nov. 2007
publication

Purification and characterization of pepsins A1 and A2 from the Antarctic rock cod Trematomus bernacchii

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27 févr. 2007
publication

The Abl SH2-kinase linker naturally adopts a conformation competent for SH3 domain binding

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01 déc. 2006
publication

The marine natural product adociasulfate-2 as a tool to identify the MT-binding region of kinesins

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15 mai 2006
publication

Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents

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01 janv. 2006
publication

Use of hydrogen/deuterium exchange mass spectrometry and mutagenesis as a tool to identify the binding region of inhibitors targeting the human mitotic kinesin Eg5

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19 oct. 2004
publication

Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5

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