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© Research
Publication : Mass Spectrometry Analysis for Protein-Protein Interactions and Dynamics. M. Chance, editor. Wiley, Hoboken, NJ (2008)

Hydrogen exchange mass spectrometry: principles and capabilities

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Mass Spectrometry Analysis for Protein-Protein Interactions and Dynamics. M. Chance, editor. Wiley, Hoboken, NJ (2008) - 01 Jan 2008

Brier, Sebastien, and John R. Engen

Brier, S., & Engen, J. R. (2008). Hydrogen exchange mass spectrometry: principles and capabilities. Mass Spectrometry Analysis for Protein-Protein Interactions and Dynamics. M. Chance, editor. Wiley, Hoboken, NJ, 11-43.

Protein research has become important in biomedicine, biotechnology, pharmaceutical research and
drug design, driven by advances in understanding the human genome and the impact that has. This new
reference presents a wide variety of mass spectrometry methods used to explore structural mechanisms,
protein dynamics and interactions between proteins in one accessible source. Preliminary chapters cover
mass spectrometry methods for examining proteins and are followed by chapters devoted to presenting
very practical, how-to methods in a detailed way. Methods discussed in the book include deuterium
exchange, covalent labeling, foot printing, plistex, and computational approaches. This is the ideal
reference for academic and industry researchers working with proteins and protein chemists at the
bench chemist level working in the pharmaceutical and biotechnology industries.