Timeline

Vincent Bondet

Research Engineer

02 Sep 2024

publication

SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency.

28 Aug 2024

publication

Hereditary C1q Deficiency is Associated with Type 1 Interferon-Pathway Activation and a High Risk of Central Nervous System Inflammation.

15 Nov 2023

news

New publication – Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses

09 Aug 2023

publication

Dissecting human population variation in single-cell responses to SARS-CoV-2

01 Aug 2023

publication

Heterogeneity and functions of the 13 IFN-α subtypes – lucky for some?

12 May 2023

publication

JAK Inhibition in Aicardi-Goutières Syndrome: a Monocentric Multidisciplinary Real-World Approach Study.

01 Apr 2023

publication

Central Role of Macrophages and Nucleic Acid Release in Myasthenia Gravis Thymus.

17 Jan 2023

publication

Inactive disease in patients with lupus is linked to autoantibodies to type I interferons that normalize blood IFNα and B cell subsets.

05 Dec 2022

publication

Juvenile Neuropsychiatric Systemic Lupus Erythematosus: Identification of Novel Central Neuroinflammation Biomarkers.

25 Nov 2022

publication

Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity.

15 Nov 2022

publication

Enhanced TLR3 responsiveness in hepatitis C virus resistant women from the Irish anti-D cohort.

28 Jun 2022

publication

Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation.

20 Jun 2022

publication

Variability of Primary Sjögren’s Syndrome Is Driven by Interferon-α and Interferon-α Blood Levels Are Associated With the Class II HLA-DQ Locus.

09 Jun 2022

publication

Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming.

18 Apr 2022

publication

CXCR3 Expression Pattern on CD4+ T Cells and IP-10 Levels with Regard to the HIV-1 Reservoir in the Gut-Associated Lymphatic Tissue.

31 Mar 2022

publication

Activation of NLRP3 Inflammasome in the Skin of Patients with Systemic and Cutaneous Lupus Erythematosus.

28 Mar 2022

news

New publication – Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC transplanted SCID patients with IL2RG/JAK3 deficiency

23 Feb 2022

publication

Efficacy and tolerance of corticosteroids and methotrexate in patients with juvenile dermatomyositis: a retrospective cohort study.

14 Feb 2022

publication

Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC transplanted SCID patients with IL2RG/JAK3 deficiency.

01 Feb 2022

publication

Primary immune responses are negatively impacted by persistent herpesvirus infections in older people: results from an observational study on healthy subjects and a vaccination trial on subjects aged more than 70 years old.

01 Jan 2022

publication

Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses.

01 Sep 2021

publication

Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection.

23 Aug 2021

publication

Onset and Relapse of Juvenile Dermatomyositis Following Asymptomatic SARS-CoV-2 Infection.

01 Aug 2021

publication

Differential levels of IFNα subtypes in autoimmunity and viral infection.

04 Jun 2021

publication

Regulation of the acetylcholine/α7nAChR anti-inflammatory pathway in COVID-19 patients.

01 May 2021

publication

HIV DNA reservoir and elevated PD-1 expression of CD4 T-cell subsets particularly persist in the terminal ileum of HIV-positive patients despite cART.

01 Apr 2021

publication

Differential Expression of Interferon-Alpha Protein Provides Clues to Tissue Specificity Across Type I Interferonopathies.

12 Feb 2021

publication

JAK inhibitors are effective in a subset of patients with juvenile dermatomyositis: a monocentric retrospective study.

01 Feb 2021

publication

Overview of STING-Associated Vasculopathy with Onset in Infancy (SAVI) Among 21 Patients.

04 Jan 2021

publication

TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons.

01 Jan 2021

publication

Constitutive IFNα Protein Production in Bats.

01 Jan 2021

publication

Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment.

02 Nov 2020

publication

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling.

24 Sep 2020

publication

Dysregulation of tryptophan catabolism at the host-skin microbiota interface in Hidradenitis Suppurativa.

19 Sep 2020

publication

Absence of Neuronal Autoantibodies in Neuropsychiatric Systemic Lupus Erythematosus.

13 Jul 2020

publication

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.

02 Jul 2020

team

Translational Immunology

22 Jun 2020

publication

Three Copies of Four Interferon Receptor Genes Underlie a Mild Type I Interferonopathy in Down Syndrome.

19 Jun 2020

publication

Catatonia in a patient with Aicardi-Goutières syndrome efficiently treated with immunoadsorption.

05 Jun 2020

publication

Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes.

05 Mar 2020

publication

The proteome of neutrophils in sickle cell disease reveals an unexpected activation of interferon alpha signaling pathway

01 Jan 2020

publication

Decreased Type I Interferon Production by Plasmacytoid Dendritic Cells Contributes to Severe Dengue.

13 Dec 2019

publication

Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in

26 Nov 2019

publication

Cardiac valve involvement in -related type I interferonopathy

26 Nov 2019

publication

PSMB10, the last immunoproteasome gene missing for PRAAS

22 Nov 2019

publication

Anti-MDA5 juvenile idiopathic inflammatory myopathy: a specific subgroup defined by differentially enhanced interferon-α signalling

30 Oct 2019

publication

Use of ruxolitinib in COPA syndrome manifesting as life-threatening alveolar haemorrhage

30 Oct 2019

publication

Inhibition of IFNα secretion in cells from patients with juvenile dermatomyositis under TBK1 inhibitor treatment revealed by single-molecular assay technology

05 Oct 2019

publication

Risk factors associated with myasthenia gravis in thymoma patients: The potential role of thymic germinal centers

05 Sep 2019

publication

Circulating interferon-α measured with a highly sensitive assay as a biomarker for juvenile inflammatory myositis activity

22 Aug 2019

publication

Plasma Type I IFN Protein Concentrations in Human Tuberculosis

10 Jul 2019

publication

Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment

14 Jun 2019

publication

Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles

22 May 2019

publication

IP-10 contributes to the inhibition of mycobacterial growth in an ex vivo whole blood assay

08 Apr 2019

publication

Delineating the healthy human skin UV response and early induction of interferon pathway in cutaneous lupus erythematosus

07 Mar 2019

publication

Interferon signature in patients with STAT1 gain-of-function mutation is epigenetically determined

18 Feb 2019

publication

Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth

04 Jan 2019

team

Production and Purification of Recombinant Proteins Technological Platform

06 Dec 2018

publication

Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome

01 Nov 2018

publication

A child with severe juvenile dermatomyositis treated with ruxolitinib

03 Oct 2018

publication

Efficacy of JAK1/2 inhibition in the treatment of chilblain lupus due to TREX1 deficiency

07 Sep 2018

publication

First description of agonist and antagonist IP-10 in urine of patients with active TB

05 Jul 2018

publication

Interplay of DDP4 and IP-10 as a Potential Mechanism for Cell Recruitment to Tuberculosis Lesions

14 Jun 2018

publication

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

01 Jun 2018

publication

JAK inhibitor improves type I interferon induced damage: proof of concept in dermatomyositis

01 Jun 2018

publication

Comment on: ‘Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors’ by Giannelou : mutations in result in a constitutive activation of type I interferon signalling

19 Dec 2017

publication

Type I interferon-mediated autoinflammation due to DNase II deficiency

20 Apr 2017

publication

TBK1/IKKE blockade inhibits mutant STING mediated inflammatory response in patient cells

18 Apr 2017

publication

Detection of interferon alpha protein reveals differential levels and cellular sources in disease

10 Sep 2015

project

Biomarker discovery and viral disease pathogenesis

10 Sep 2015

project

Functional immune response to Mycobacteria tuberculosis derived antigen

11 Oct 2013

publication

Structural and functional characterization of an orphan ATP-binding cassette ATPase involved in manganese utilization and tolerance in Leptospira spp

27 Jul 2007

publication

A little guide for advanced search:

SARS-CoV-2 brainstem encephalitis in human inherited DBR1 deficiency.

Hereditary C1q Deficiency is Associated with Type 1 Interferon-Pathway Activation and a High Risk of Central Nervous System Inflammation.

New publication – Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses

Dissecting human population variation in single-cell responses to SARS-CoV-2

Heterogeneity and functions of the 13 IFN-α subtypes – lucky for some?

JAK Inhibition in Aicardi-Goutières Syndrome: a Monocentric Multidisciplinary Real-World Approach Study.

Central Role of Macrophages and Nucleic Acid Release in Myasthenia Gravis Thymus.

Inactive disease in patients with lupus is linked to autoantibodies to type I interferons that normalize blood IFNα and B cell subsets.

Juvenile Neuropsychiatric Systemic Lupus Erythematosus: Identification of Novel Central Neuroinflammation Biomarkers.

Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity.

Enhanced TLR3 responsiveness in hepatitis C virus resistant women from the Irish anti-D cohort.

Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation.

Variability of Primary Sjögren’s Syndrome Is Driven by Interferon-α and Interferon-α Blood Levels Are Associated With the Class II HLA-DQ Locus.

Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming.

CXCR3 Expression Pattern on CD4+ T Cells and IP-10 Levels with Regard to the HIV-1 Reservoir in the Gut-Associated Lymphatic Tissue.

Activation of NLRP3 Inflammasome in the Skin of Patients with Systemic and Cutaneous Lupus Erythematosus.

New publication – Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC transplanted SCID patients with IL2RG/JAK3 deficiency

Efficacy and tolerance of corticosteroids and methotrexate in patients with juvenile dermatomyositis: a retrospective cohort study.

Defects in mucosal immunity and nasopharyngeal dysbiosis in HSC transplanted SCID patients with IL2RG/JAK3 deficiency.

Primary immune responses are negatively impacted by persistent herpesvirus infections in older people: results from an observational study on healthy subjects and a vaccination trial on subjects aged more than 70 years old.

Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses.

Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection.

Onset and Relapse of Juvenile Dermatomyositis Following Asymptomatic SARS-CoV-2 Infection.

Differential levels of IFNα subtypes in autoimmunity and viral infection.

Regulation of the acetylcholine/α7nAChR anti-inflammatory pathway in COVID-19 patients.

HIV DNA reservoir and elevated PD-1 expression of CD4 T-cell subsets particularly persist in the terminal ileum of HIV-positive patients despite cART.

Differential Expression of Interferon-Alpha Protein Provides Clues to Tissue Specificity Across Type I Interferonopathies.

JAK inhibitors are effective in a subset of patients with juvenile dermatomyositis: a monocentric retrospective study.

Overview of STING-Associated Vasculopathy with Onset in Infancy (SAVI) Among 21 Patients.

TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons.

Constitutive IFNα Protein Production in Bats.

Altered Immune Phenotypes and HLA-DQB1 Gene Variation in Multiple Sclerosis Patients Failing Interferon β Treatment.

Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling.

Dysregulation of tryptophan catabolism at the host-skin microbiota interface in Hidradenitis Suppurativa.

Absence of Neuronal Autoantibodies in Neuropsychiatric Systemic Lupus Erythematosus.

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.

Translational Immunology

Three Copies of Four Interferon Receptor Genes Underlie a Mild Type I Interferonopathy in Down Syndrome.

Catatonia in a patient with Aicardi-Goutières syndrome efficiently treated with immunoadsorption.

Innate immune stimulation of whole blood reveals IFN-1 hyper-responsiveness in type 1 diabetes.

The proteome of neutrophils in sickle cell disease reveals an unexpected activation of interferon alpha signaling pathway

Decreased Type I Interferon Production by Plasmacytoid Dendritic Cells Contributes to Severe Dengue.

Severe type I interferonopathy and unrestrained interferon signaling due to a homozygous germline mutation in

Cardiac valve involvement in -related type I interferonopathy

PSMB10, the last immunoproteasome gene missing for PRAAS

Anti-MDA5 juvenile idiopathic inflammatory myopathy: a specific subgroup defined by differentially enhanced interferon-α signalling

Use of ruxolitinib in COPA syndrome manifesting as life-threatening alveolar haemorrhage

Inhibition of IFNα secretion in cells from patients with juvenile dermatomyositis under TBK1 inhibitor treatment revealed by single-molecular assay technology

Risk factors associated with myasthenia gravis in thymoma patients: The potential role of thymic germinal centers

Circulating interferon-α measured with a highly sensitive assay as a biomarker for juvenile inflammatory myositis activity

Plasma Type I IFN Protein Concentrations in Human Tuberculosis

Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment

Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles

IP-10 contributes to the inhibition of mycobacterial growth in an ex vivo whole blood assay

Delineating the healthy human skin UV response and early induction of interferon pathway in cutaneous lupus erythematosus

Interferon signature in patients with STAT1 gain-of-function mutation is epigenetically determined

Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth

Production and Purification of Recombinant Proteins Technological Platform

Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome

A child with severe juvenile dermatomyositis treated with ruxolitinib

Efficacy of JAK1/2 inhibition in the treatment of chilblain lupus due to TREX1 deficiency

First description of agonist and antagonist IP-10 in urine of patients with active TB

Interplay of DDP4 and IP-10 as a Potential Mechanism for Cell Recruitment to Tuberculosis Lesions

Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

JAK inhibitor improves type I interferon induced damage: proof of concept in dermatomyositis

Comment on: ‘Aberrant tRNA processing causes an autoinflammatory syndrome responsive to TNF inhibitors’ by Giannelou : mutations in result in a constitutive activation of type I interferon signalling

Type I interferon-mediated autoinflammation due to DNase II deficiency

TBK1/IKKE blockade inhibits mutant STING mediated inflammatory response in patient cells

Detection of interferon alpha protein reveals differential levels and cellular sources in disease

Biomarker discovery and viral disease pathogenesis

Functional immune response to Mycobacteria tuberculosis derived antigen

Structural and functional characterization of an orphan ATP-binding cassette ATPase involved in manganese utilization and tolerance in Leptospira spp

The crystal structure of M. leprae ML2640c defines a large family of putative S-adenosylmethionine-dependent methyltransferases in mycobacteria