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About

The Imagine-Institut Pasteur unit of Heart Morphogenesis aims to uncover embryological mechanisms generating the three dimensional shape of the heart and to assess the impact for human diseases. We study how cells are patterned and how coordinated cell behaviour generates 3D tissue deformations to shape the organ. Heart development We address these questions using cutting-edge technologies in genetics, omics, 3D imaging, quantitative analyses of complex data and computer simulations. Our study meets novel challenges requiring interdisciplinary efforts in collaboration with computational scientists and clinicians, to quantify biological processes or examine the clinical impact of fundamental knowledge. In the last years, we have developed several tools to image, simulate and quantify heart development and malformation in 3D. Our work in the mouse provides conceptual advances in developmental biology, as well as novel perspectives in human cardiology.  

Former Members

2000
2000
Name
Position
2009
2015
Chiara Ragni
PhD Student
2009
2017
Jean-François Le Garrec
Post-doc
2012
2015
Nicolas Diguet
Post-doc
2012
2012
Ewa Zlotek-Zlotkiewicz
Undergraduate Student
2013
2018
Tommaso Lucchesi
PhD Student
2014
2016
Maryse Brandt
Administrative Staff
2015
2021
Daniel Darby
PhD Student
2015
2015
Hugo Moisset
Medical student
2015
2017
Risa Kitasato
Clinician
2016
2017
Jing Xie
Research Engineer
2016
2016
Julie Mery-Tahraoui 
Undergraduate Student
2016
2018
Dong Han
Post-doc
2017
2017
Ameya Murukutla
Medical Student
2017
2017
Johanna Lokmer
Medical student
2018
2018
Claire Shea
Post-doc
2018
2018
Nji Asong
Undergraduate Student
2018
2019
Clara Guijarro Calvo
Research Engineer
2018
2019
Héloïse Foucambert Millérioux
Medical student
2018
2023
Tobias Holm Bønnelykke
PhD student
2019
2020
Sami Chatila
Medical student
2020
2021
Adrien Borgel
Pharmacy student
2018
2021
Ségolène Bernheim
PhD student and cardiac pediatrician
2022
2023
Ayushi Hegde
Undergraduate Student
2023
2023
Kristina Nimchenko
Post-doc
2022
2024
Cindy Michel
Post-doc
2024
2024
Zoé Oulerich
Research Engineer
Show all

Projects

Project
Ongoing
6 Members

Left-right asymmetry of the heart

Sigolène Meilhac (PI)

Morphogenesis, that is the acquisition of a shape, is essential for organ function. The heart is an asymmetric organ, in which the left and right sides are fully separated to drive the double blood […]
Project
Ongoing
3 Members

Mechanism of heart growth

Sigolène Meilhac (PI)

Growth of the heart is required to adapt to the increasing hemodynamic load of the developing organism. Physiologically, heart growth is mainly driven by the proliferation of myocardial cells in utero and by cell […]

Transversal Project

The IP Stem Cell Initiative

The Stem Cell Concept – Constructing, Deconstructing and Reconstructing Tissues for organismal health Human biology and molecular medicine are rapidly becoming data-rich fields that are fueled in part by large-scale longitudinal studies of patients […]

INCEPTION – Institut Convergence for the study of Emergence of Pathology Through Individuals and Populations

IINCEPTION Goal The Inception aims to develop a core structure to mobilize data resources, numerical sciences, and fundamental experimental biology in various health issues (Official website here: https://www.inception-program.fr/en). The inception program uses Integrative Biology, […]

Quantitative biology

The Quantitative Biology program of the Institut Pasteur is intended to facilitate research and education at the interface of biology and the more quantitative sciences. One of the major aims of Quantitative Biology is thus to […]

LabEx Revive – Regenerative biology & medicine

Rationale and Objectives of Revive Consortium Major advancements in stem cell biology have paved the way for concerted research activities on the fundamental biology of stem cells and their applications in the clinic. The […]

Fundings

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We are always interested in hearing from students and post-doctoral candidates who are eager to join our team.

Pictures & Media

2024 Heart Morphogenesis group
2022 Heart Morphogenesis group
2021 Heart Morphogenesis group

2019 Heart Morphogenesis group

2018 Heart Morphogenesis group
2016 Heart Morphogenesis group
2016 Heart Morphogenesis group
2013 Heart Morphogenesis group
2013 Heart Morphogenesis group

Contact

Courriel : sigolene.meilhac[at]pasteur.fr Groupe Imagine-Institut Pasteur – Address : Institut Imagine, 24 boulevard du Montparnasse 75015, Paris France