Interactions between Human T lymphotropic virus type 1 (HTLV-1) and the blood-brain barrier
Human T-lymphotropic virus type 1 (HTLV-1) is the etiological agent of a slowly progressive neurodegenerative disease, HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). This disease develops upon infiltration of HTLV-1-infected lymphocytes into the central nervous system, […]
Drug Discovery & Screening at Institut Pasteur
The Technological Targeted Action Drug Discovery and Screening (ATC-DDS) coordinates projects and collaborations at the Institut Pasteur Paris campus on therapeutic development. It raises awareness for DDS in basic research projects and stimulates intra-campus […]
2019Absence of accessory genes in a divergent simian T-lymphotropic virus type 1 isolated from a bonnet macaque (Macaca radiata)., PLoS Negl Trop Dis. 2019 Jul 8;13(7):e0007521. .
2018Proteomic analysis of plasma extracellular vesicles reveals mitochondrial stress upon HTLV-1 infection., Sci Rep 2018 03; 8(1): 5170.
2017HTLV-1-induced leukotriene B4 secretion by T cells promotes T cell recruitment and virus propagation., Nat Commun. 2017 Jun 22;8:15890..
2016Human T-Lymphotropic Virus Type 1-Induced Overexpression of Activated Leukocyte Cell Adhesion Molecule (ALCAM) Facilitates Trafficking of Infected Lymphocytes through the Blood-Brain Barrier, J. Virol. 2016 Aug;90(16):7303-12.
2014Northern African strains of human T-lymphotropic virus type 1 arose from a recombination event, J. Virol. 2014 Sep;88(17):9782-8.
2010Highly active antiretroviral treatment against STLV-1 infection combining reverse transcriptase and HDAC inhibitors, Blood 2010 Nov;116(19):3802-8.
2008Alteration of blood-brain barrier integrity by retroviral infection, PLoS Pathog. 2008 Nov;4(11):e1000205.
2007Human blood-brain barrier disruption by retroviral-infected lymphocytes: role of myosin light chain kinase in endothelial tight-junction disorganization, J. Immunol. 2007 Aug;179(4):2576-83.
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