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© Research
Publication : Pharmaceutical research

Quantitative ADME proteomics – CYP and UGT enzymes in the Beagle dog liver and intestine

Team: Mass Spectrometry for Biology
Team: Biomics
Team: Proteomics
Member: Mariette Matondo
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Pharmaceutical research - 18 Jul 2014

Heikkinen AT, Friedlein A, Matondo M, Hatley OJ, Petsalo A, Juvonen R, Galetin A, Rostami-Hodjegan A, Aebersold R, Lamerz J, Dunkley T, Cutler P, Parrott N

Link to Pubmed [PMID] – 25033762

Pharm. Res. 2015 Jan;32(1):74-90

Beagle dogs are used to study oral pharmacokinetics and guide development of drug formulations for human use. Since mechanistic insight into species differences is needed to translate findings in this species to human, abundances of cytochrome P450 (CYP) and uridine diphosphate glucuronosyltransferase (UGT) drug metabolizing enzymes have been quantified in dog liver and intestine.