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© Research
Publication : Cerebral cortex (New York, N.Y. : 1991)

Modulation of the mouse prefrontal cortex activation by neuronal nicotinic receptors during novelty exploration but not by exploration of a familiar environment.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cerebral cortex (New York, N.Y. : 1991) - 01 May 2012

Bourgeois JP, Meas-Yeadid V, Lesourd AM, Faure P, Pons S, Maskos U, Changeux JP, Olivo-Marin JC, Granon S,

Link to Pubmed [PMID] – 21810785

Link to DOI [DOI] – 10.1093/cercor/bhr159

Cereb. Cortex 2012 May; 22(5): 1007-15

Organization of locomotor behavior is altered in mice knockout for the β2 subunit of the nicotinic receptor-β2-/- mice-during novelty exploration. We investigated the neuronal basis of this alteration by measuring activation of the immediate early gene c-fos in the brains of wild-type (WT) and β2-/- mice after exploration of a novel or a familiar environment. Results show 1) no constitutive difference between WT and β2-/- mice in c-fos gene expression in any brain region, 2) novelty exploration triggered activation of the hippocampus and the reward circuit while exploration of a familiar environment produced increased activation in the amygdala, and 3) in β2-/- mice, exploration of novelty, but not familiarity, induced an increase in activation in the prelimbic prefrontal cortex (PFC) compared with WT mice. c-Fos immunoreactivity after different stages of learning in a maze increased similarly in the prelimbic area of both WT and β2-/- mice, while their performance differed. In WT mice, exploration of a novel environment triggered an increase in c-Fos expression in the reward circuit and the hippocampus, while in β2-/- mice, the amygdala and the motor cortex were additionally activated. We also highlight the role of nicotinic receptors during activation of the PFC, specifically during free exploration of a novel environment.

https://pubmed.ncbi.nlm.nih.gov/21810785