• 2025
  Sarah H Merkling, Elodie Couderc, Anna B Crist, Stéphanie Dabo, Josquin Daron, Natapong Jupatanakul, Myriam Burckbuchler, Thomas Vial, Odile Sismeiro, Rachel Legendre, Adrien Pain, Hugo Varet, Davy Jiolle, Diego Ayala, Christophe Paupy, Eric Marois, Louis Lambrechts, Dengue virus susceptibility in Aedes aegypti linked to natural cytochrome P450 promoter variants, Nature Communications, 2025, 16 (1), pp.7468. ⟨10.1038/s41467-025-62693-y⟩.
• 2024
  Hafner L, Gadin E, Huang L, Frouin A, Laporte F, Gaultier C, Vieira A, Maudet C, Varet H, Moura A, Bracq-Dieye H, Tessaud-Rita N, Maury M, Dazas M, Legendre R, Gastineau P, Tsai YH, Coppée JY, Charlier C, Patin E, Chikhi R, Rocha EPC, Leclercq A, Disson O, Aschard H, Lecuit M, Differential stress responsiveness determines intraspecies virulence heterogeneity and host adaptation in Listeria monocytogenes., Nat Microbiol 2024 Dec; 9(12): 3345-3361.
• 2024
  Coppolino F, De Gaetano GV, Claverie C, Sismeiro O, Varet H, Legendre R, Pellegrini A, Berbiglia A, Tavella L, Lentini G, Famà A, Barbieri G, Pietrocola G, Teti G, Firon A, Beninati C, The SaeRS two-component system regulates virulence gene expression in group B Streptococcus during invasive infection., mBio 2024 Sep; 15(9): e0197524.
• 2024
  Aouadi W, Najburg V, Legendre R, Varet H, Kergoat L, Tangy F, Larrous F, Komarova AV, Bourhy H, Comparative analysis of rabies pathogenic and vaccine strains detection by RIG-I-like receptors., Microbes Infect 2024 ; 26(4): 105321.
• 2024
  Labusch M, Thetiot M, Than-Trong E, Morizet D, Coolen M, Varet H, Legendre R, Ortica S, Mancini L, Bally-Cuif L, Prosaposin maintains adult neural stem cells in a state associated with deep quiescence., Stem Cell Reports 2024 Apr; 19(4): 515-528.
• 2024
  Brissac T, Guyonnet C, Sadouni A, Hernández-Montoya A, Jacquemet E, Legendre R, Sismeiro O, Trieu-Cuot P, Lanotte P, Tazi A, Firon A, Coordinated regulation of osmotic imbalance by c-di-AMP shapes ß-lactam tolerance in Group B Streptococcus., Microlife 2024 ; 5(): uqae014.
• 2023
  Pasquereau-Kotula E, du Merle L, Sismeiro O, Pietrosemoli N, Varet H, Legendre R, Trieu-Cuot P, Dramsi S, Transcriptome profiling of human col\onic cells exposed to the gut pathobiont Streptococcus gallolyticus subsp. gallolyticus., PLoS One 2023 ; 18(11): e0294868.
• 2023
  Di Carlo SE, Raffenne J, Varet H, Ode A, Granados DC, Stein M, Legendre R, Tuckermann J, Bousquet C, Peduto L, Depletion of slow-cycling PDGFRα+ADAM12+ mesenchymal cells promotes antitumor immunity by restricting macrophage efferocytosis., Nat Immunol 2023 Oct; (): .
• 2022
  Vabret N, Najburg V, Solovyov A, Gopal R, McClain C, Šulc P, Balan S, Rahou Y, Beauclair G, Chazal M, Varet H, Legendre R, Sismeiro O, Sanchez David RY, Chauveau L, Jouvenet N, Markowitz M, van der Werf S, Schwartz O, Tangy F, Bhardwaj N, Greenbaum BD, Komarova AV, Y RNAs are conserved endogenous RIG-I ligands across RNA virus infection and are targeted by HIV-1., iScience 2022 Jul; 25(7): 104599.
• 2022
  Daunesse Maëlle, Legendre Rachel, Varet Hugo, Pain Adrien, Chica Claudia , ePeak: from replicated chromatin profiling data to epigenomic dynamics., NAR Genom Bioinform 2022 Jun; 4(2): lqac041.
• 2022
  Giraud É, Varet H, Legendre R, Sismeiro O, Aubry F, Dabo S, Dickson LB, Valiente Moro C, Lambrechts L, Mosquito-bacteria interactions during larval development trigger metabolic changes with carry-over effects on adult fitness., Mol Ecol 2022 Mar; 31(5): 1444-1460.
• 2022
  Piel L, Rajan KS, Bussotti G, Varet H, Legendre R, Proux C, Douché T, Giai-Gianetto Q, Chaze T, Cokelaer T, Vojtkova B, Gordon-Bar N, Doniger T, Cohen-Chalamish S, Rengaraj P, Besse C, Boland A, Sadlova J, Deleuze JF, Matondo M, Unger R, Volf P, Michaeli S, Pescher P, Späth GF, Experimental evolution links post-transcriptional regulation to Leishmania fitness gain., PLoS Pathog 2022 Mar; 18(3): e1010375.
• 2021
  Kim S, Larrous F, Varet H, Legendre R, Feige L, Dumas G, Matsas R, Kouroupi G, Grailhe R, Bourhy H, , Early Transcriptional Changes in Rabies Virus-Infected Neurons and Their Impact on Neuronal Functions., Front Microbiol 2021 ; 12(): 730892.
• 2021
  Jagla B, Libri V, Chica C, Rouilly V, Mella S, Puceat M, Hasan M, , SCHNAPPs – Single Cell sHiNy APPlication(s)., J Immunol Methods 2021 12; 499(): 113176.
• 2021
  Fule L, Halifa R, Fontana C, Sismeiro O, Legendre R, Varet H, Coppée JY, Murray GL, Adler B, Hendrixson DR, Buschiazzo A, Guo S, Liu J, Picardeau M, , Role of the major determinant of polar flagellation FlhG in the endoflagella-containing spirochete Leptospira., Mol Microbiol 2021 Oct; (): .
• 2021
  Mazzuoli MV, Daunesse M, Varet H, Rosinski-Chupin I, Legendre R, Sismeiro O, Gominet M, Kaminski PA, Glaser P, Chica C, Trieu-Cuot P, Firon A, , The CovR regulatory network drives the evolution of Group B Streptococcus virulence., PLoS Genet 2021 Sep; 17(9): e1009761.
• 2021
  Rachez C, Legendre R, Costallat M, Varet H, Yi J, Kornobis E, Muchardt C, , HP1γ binding pre-mRNA intronic repeats modulates RNA splicing decisions., EMBO Rep 2021 Jul; (): e52320.
• 2021
  Robbe-Saule M, Foulon M, Poncin I, Esnault L, Varet H, Legendre R, Besnard A, Grzegorzewicz AE, Jackson M, Canaan S, Marsollier L, Marion E, Transcriptional adaptation of Mycobacterium ulcerans in an original mouse model: New insights into the regulation of mycolacton, Virulence . 2021 Dec;12(1):1438-1451.
• 2021
  Liu Z, Raj S, van Rhijn N, Fraczek M, Michel JP, Sismeiro O, Legendre R, Varet H, Fontaine T, Bromley M, Latgé JP, , Functional Genomic and Biochemical Analysis Reveals Pleiotropic Effect of Congo Red on Aspergillus fumigatus., mBio 2021 May; 12(3): .
• 2021
  Nagaraja S, Cai MW, Sun J, Varet H, Sarid L, Trebicz-Geffen M, Shaulov Y, Mazumdar M, Legendre R, Coppée JY, Begley TJ, Dedon PC, Gourinath S, Guillen N, Saito-Nakano Y, Shimokawa C, Hisaeda H, Ankri S, , Queuine Is a Nutritional Regulator of Entamoeba histolytica Response to Oxidative Stress and a Virulence Attenuator., mBio 2021 Mar; 12(2): .
• 2021
  Machado L, Geara P, Camps J, Dos Santos M, Teixeira-Clerc F, Van Herck J, Varet H, Legendre R, Pawlotsky JM, Sampaolesi M, Voet T, Maire P, Relaix F, Mourikis P, , Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation., Cell Stem Cell 2021 Feb; (): .
• 2021
  Baillet N, Reynard S, Perthame E, Hortion J, Journeaux A, Mateo M, Carnec X, Schaeffer J, Picard C, Barrot L, Barron S, Vallve A, Duthey A, Jacquot F, Boehringer C, Jouvion G, Pietrosemoli N, Legendre R, Dillies MA, Allan R, Legras-Lachuer C, Carbonnelle C, Raoul H, Baize S, , Systemic viral spreading and defective host responses are associated with fatal Lassa fever in macaques., Commun Biol 2021 Jan; 4(1): 27.
• 2021
  Huot N, Rascle P, Planchais C, Contreras V, Passaes C, Le Grand R, Beignon AS, Kornobis E, Legendre R, Varet H, Saez-Cirion A, Mouquet H, Jacquelin B, Müller-Trutwin M, , CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues., Front Immunol 2021 ; 12(): 695148.
• 2020
  Gaultney RA, Vincent AT, Lorioux C, Coppée JY, Sismeiro O, Varet H, Legendre R, Cockram CA, Veyrier FJ, Picardeau M, , 4-Methylcytosine DNA modification is critical for global epigenetic regulation and virulence in the human pathogen Leptospira interrogans., Nucleic Acids Res 2020 Dec; 48(21): 12102-12115.
• 2020
  Lacerda Mariano L, Rousseau M, Varet H, Legendre R, Gentek R, Saenz Coronilla J, Bajenoff M, Gomez Perdiguero E, Ingersoll MA, , Functionally distinct resident macrophage subsets differentially shape responses to infection in the bladder., Sci Adv 2020 Nov; 6(48): .
• 2020
  Zavala-Alvarado C, Sismeiro O, Legendre R, Varet H, Bussotti G, Bayram J, G Huete S, Rey G, Coppée JY, Picardeau M, Benaroudj N, The transcriptional response of pathogenic Leptospira to peroxide reveals new defenses against infection-related oxidative stress., PLoS Pathog 2020 Oct; 16(10): e1008904.
• 2020
  Silvia Castellanos-Castro, Arturo Aguilar-Rojas, Mariette Matondo, Quentin Gian Gianetto, Hugo Varet, Odile Sismeiro, Rachel Legendre, Julien Fernandes, David Hardy, Jean Yves Coppée, Jean Christophe Olivo-Marin, Nancy Guillen, Human Immune Response Triggered by Entamoeba histolytica in a 3D-Intestinal Model, Eukaryome Impact on Human Intestine Homeostasis and Mucosal Immunology. Springer, Cham.
• 2020
  Pourpre R, Naudon L, Meziane H, Lakisic G, Jouneau L, Varet H, Legendre R, Wendling O, Selloum M, Proux C, Coppée JY, Herault Y, Bierne H, BAHD1 haploinsufficiency results in anxiety-like phenotypes in male mice, PLoS ONE 2020;15(5):e0232789.
• 2020
  Rey C, Chang YY, Latour-Lambert P, Varet H, Proux C, Legendre R, Coppée JY, Enninga J, Transcytosis subversion by M cell-to-enterocyte spread promotes Shigella flexneri and Listeria monocytogenes  intracellular bacterial dissemination, PLoS Pathog. 2020 Apr;16(4):e1008446.
• 2020
  Derbise A, Echenique-Rivera H, Garcia-Lopez M, Beau R, Mattei M, Varet H, Dersch P, Pizarro-Cerdá J, , Bread Feeding Is a Robust and More Physiological Enteropathogen Administration Method Compared to Oral Gavage., Infect Immun 2020 03; 88(4): .
• 2020
  Lecoeur H, Prina E, Rosazza T, Kokou K, N'Diaye P, Aulner N, Varet H, Bussotti G, Xing Y, Milon G, Weil R, Meng G, Späth GF, Targeting Macrophage Histone H3 Modification as a Leishmania Strategy to Dampen the NF-κB/NLRP3-Mediated Inflammatory Response., Cell Rep 2020 Feb; 30(6): 1870-1882.e4.
• 2020
  Merkling SH, Raquin V, Dabo S, Henrion-Lacritick A, Blanc H, Moltini-Conclois I, Frangeul L, Varet H, Saleh MC, Lambrechts L, , Tudor-SN Promotes Early Replication of Dengue Virus in the Aedes aegypti Midgut., iScience 2020 Feb; 23(2): 100870.
• 2020
  Dieme C, Zmarlak NM, Brito-Fravallo E, Travaillé C, Pain A, Cherrier F, Genève C, Calvo-Alvarez E, Riehle MM, Vernick KD, Rotureau B, Mitri C, Exposure of Anopheles mosquitoes to trypanosomes reduces reproductive fitness and enhances susceptibility to Plasmodium., PLoS Negl Trop Dis 2020 Feb; 14(2): e0008059.
• 2019
  Dubois V, Pawlik A, Bories A, Le Moigne V, Sismeiro O, Legendre R, Varet H, Rodríguez-Ordóñez MDP, Gaillard JL, Coppée JY, Brosch R, Herrmann JL, Girard-Misguich F, Mycobacterium abscessus virulence traits unraveled by transcriptomic profiling in amoeba and macrophages, PLoS Pathog. 2019 Nov;15(11):e1008069.
• 2019
  Nardini L, Holm I, Pain A, Bischoff E, Gohl DM, Zongo S, Guelbeogo WM, Sagnon N, Vernick KD, Riehle MM, Influence of genetic polymorphism on transcriptional enhancer activity in the malaria vector Anopheles coluzzii, Sci Rep 2019 Oct;9(1):15275.
• 2019
  Carballido Lopez A, Cunrath O, Forster A, Pérard J, Graulier G, Legendre R, Varet H, Sismeiro O, Perraud Q, Pesset B, Saint Auguste P, Bumann D, Mislin GLA, Coppee JY, Michaud-Soret I, Fechter P, Schalk IJ, Non-specific interference of cobalt with siderophore-dependent iron uptake pathways, Metallomics 2019 Nov;11(11):1937-1951.
• 2019
  Quadrana L, Etcheverry M, Gilly A, Caillieux E, Madoui MA, Guy J, Bortolini Silveira A, Engelen S, Baillet V, Wincker P, Aury JM, Colot V, , Transposition favors the generation of large effect mutations that may facilitate rapid adaption., Nat Commun 2019 07; 10(1): 3421.
• 2019
  Hommel B, Sturny-Leclère A, Volant S, Veluppillai N, Duchateau M, Yu CH, Hourdel V, Varet H, Matondo M, Perfect JR, Casadevall A, Dromer F, Alanio A, Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype., PLoS Pathog 2019 Jul; 15(7): e1007945.
• 2019
  Van den Bossche A, Varet H, Sury A, Sismeiro O, Legendre R, Coppee JY, Mathys V, Ceyssens PJ, Transcriptional profiling of a laboratory and clinical Mycobacterium tuberculosis strain suggests respiratory poisoning upon exposure to delamanid, Tuberculosis (Edinb) 2019 Jul;117:18-23.
• 2019
  Liégard B, Baillet V, Etcheverry M, Joseph E, Lariagon C, Lemoine J, Evrard A, Colot V, Gravot A, Manzanares-Dauleux MJ, Jubault M, , Quantitative resistance to clubroot infection mediated by transgenerational epigenetic variation in Arabidopsis., New Phytol 2019 04; 222(1): 468-479.
• 2019
  Nadège Gouignard, Floriane Cherrier, Emma Brito-Fravallo, Adrien Pain, Natalia Marta Zmarlak, Katia Cailliau, Corinne Genève, Kenneth D Vernick, Colette Dissous, Christian Mitri, Dual role of the Anopheles coluzzii Venus Kinase Receptor in both larval growth and immunity., Scientific Reports, 2019, 9 (1), pp.3615. ⟨10.1038/s41598-019-40407-x⟩.
• 2019
  Boettcher M, Covarrubias S, Biton A, Blau J, Wang H, Zaitlen N, McManus MT, Tracing cellular heterogeneity in pooled genetic screens via multi-level barcoding, BMC Genomics 2019 Feb;20(1):107.
• 2019
  Coya JM, De Matteis L, Giraud-Gatineau A, Biton A, Serrano-Sevilla I, Danckaert A, Dillies MA, Gicquel B, De la Fuente JM, Tailleux L, Tri-mannose grafting of chitosan nanocarriers remodels the macrophage response to bacterial infection, J Nanobiotechnology 2019 Jan;17(1):15.
• 2019
  Gouder L, Vitrac A, Goubran-Botros H, Danckaert A, Tinevez JY, André-Leroux G, Atanasova E, Lemière N, Biton A, Leblond CS, Poulet A, Boland A, Deleuze JF, Benchoua A, Delorme R, Bourgeron T, Cloëz-Tayarani I, , Altered spinogenesis in iPSC-derived cortical neurons from patients with autism carrying de novo SHANK3 mutations., Sci Rep 2019 01; 9(1): 94.
• 2019
  Reynard S, Journeaux A, Gloaguen E, Schaeffer J, Varet H, Pietrosemoli N, Mateo M, Baillet N, Laouenan C, Raoul H, Mullaert J, Baize S, Immune parameters and outcomes during Ebola virus disease, JCI Insight 2019 Jan;4(1).
• 2019
  Furci L, Jain R, Stassen J, Berkowitz O, Whelan J, Roquis D, Baillet V, Colot V, Johannes F, Ton J, , Identification and characterisation of hypomethylated DNA loci controlling quantitative resistance in Arabidopsis., Elife 2019 01; 8(): .
• 2018
  Amraoui F, Pain A, Piorkowski G, Vazeille M, Couto-Lima D, de Lamballerie X, Lourenço-de-Oliveira R, Failloux AB, Experimental Adaptation of the Yellow Fever Virus to the Mosquito Aedes albopictus and Potential risk of urban epidemics in Brazil, South America, Sci Rep 2018 Sep;8(1):14337.
• 2018
  Hugo Varet, Jean-Yves Coppée, checkMyIndex: a web-based R/Shiny interface for choosing compatible sequencing indexes, Bioinformatics, 2018.
• 2018
  Carissimo G, Pain A, Belda E, Vernick KD, Highly focused transcriptional response of Anopheles coluzzii to O’nyong nyong arbovirus during the primary midgut infection, BMC Genomics 2018 Jul;19(1):526.
• 2018
  Rochat T, Bohn C, Morvan C, Le Lam TN, Razvi F, Pain A, Toffano-Nioche C, Ponien P, Jacq A, Jacquet E, Fey PD, Gautheret D, Bouloc P, The conserved regulatory RNA RsaE down-regulates the arginine degradation pathway in Staphylococcus aureus, Nucleic Acids Res. 2018 Jul;.
• 2018
  Cui L, Vigouroux A, Rousset F, Varet H, Khanna V, Bikard D, A CRISPRi screen in E. coli reveals sequence-specific toxicity of dCas9, Nat Commun. 2018 May 15;9(1):1912. doi: 10.1038/s41467-018-04209-5.
• 2018
  Cubi R, Vembar SS, Biton A, Franetich JF, Bordessoulles M, Sossau D, Zanghi G, Bosson-Vanga H, Benard M, Moreno A, Dereuddre-Bosquet N, Le Grand R, Scherf A, Mazier D, Laser capture microdissection enables transcriptomic analysis of dividing and quiescent liver stages of Plasmodium relapsing species, Cell. Microbiol. 2017 08;19(8).
• 2018
  Boettcher M, Tian R, Blau JA, Markegard E, Wagner RT, Wu D, Mo X, Biton A, Zaitlen N, Fu H, McCormick F, Kampmann M, McManus MT, Dual gene activation and knockout screen reveals directional dependencies in genetic networks, Nat. Biotechnol. 2018 02;36(2):170-178.
• 2017
  Prieto Barja P, Pescher P, Bussotti G, Dumetz F, Imamura H, Kedra D, Domagalska M, Chaumeau V, Himmelbauer H, Pages M, Sterkers Y, Dujardin JC, Notredame C, Späth GF, Haplotype selection as an adaptive mechanism in the protozoan pathogen Leishmania donovani, Nat Ecol Evol 2017 Dec;1(12):1961-1969.
• 2017
  Chica C, Louis A, Roest Crollius H, Colot V, Roudier F, Comparative epigenomics in the Brassicaceae reveals two evolutionarily conserved modes of PRC2-mediated gene regulation, Genome Biol. 2017 Oct;18(1):207.
• 2017
  Zhao W, Siegel D, Biton A, Tonqueze OL, Zaitlen N, Ahituv N, Erle DJ, CRISPR-Cas9-mediated functional dissection of 3′-UTRs, Nucleic Acids Res. 2017 Oct;45(18):10800-10810.
• 2017
  Riehle MM, Bukhari T, Gneme A, Guelbeogo WM, Coulibaly B, Fofana A, Pain A, Bischoff E, Renaud F, Beavogui AH, Traore SF, Sagnon N, Vernick KD, The Anopheles gambiae 2La chromosome inversion is associated with susceptibility to Plasmodium falciparum in Africa, Elife 2017 Jun;6.
• 2017
  Dumetz F, Imamura H, Sanders M, Seblova V, Myskova J, Pescher P, Vanaerschot M, Meehan CJ, Cuypers B, De Muylder G, Späth GF, Bussotti G, Vermeesch JR, Berriman M, Cotton JA, Volf P, Dujardin JC, Domagalska MA, Modulation of Aneuploidy in during Adaptation to Different and Environments and Its Impact on Gene Expression, mBio 2017 05;8(3).
• 2017
  Bécavin C, Koutero M, Tchitchek N, Cerutti F, Lechat P, Maillet N, Hoede C, Chiapello H, Gaspin C, Cossart P, Listeriomics: an Interactive Web Platform for Systems Biology of Listeria, mSystems 2017 Mar-Apr;2(2).
• 2017
  Ribet D, Lallemand-Breitenbach V, Ferhi O, Nahori M-A, Varet H, de Thé H, Cossart P., Promyelocytic Leukemia Protein (PML) Controls Listeria monocytogenes Infection, mBio 8:e02179-16..
• 2015
  Tebbi A, Levillayer F, Jouvion G, Fiette L, Soubigou G, Varet H, Boudjadja N, Cairo S, Hashimoto K, Suzuki AM, Carninci P, Carissimo A, di Bernardo D, Wei Y, Deficiency of multidrug resistance 2 contributes to cell transformation through oxidative stress, Carcinogenesis 2016 Jan;37(1):39-48.
• 2015
  Petrini E, Baillet V, Cridge J, Hogan CJ, Guillaume C, Ke H, Brandetti E, Walker S, Koohy H, Spivakov M, Varga-Weisz P, , A new phosphate-starvation response in fission yeast requires the endocytic function of myosin I., J Cell Sci 2015 Oct; 128(20): 3707-13.