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  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Full Professor
  • Graduate Student
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
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Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Jan 2019
Ending Date
31
Dec 2021
Status
Ongoing
Members
5
Structures
2

About

The ability of an organism to interact with its environment is an essential part of life at the cellular, organismal and species levels. In many cases, rapid cellular adaptation involves modifications to chromatin, which is comprised of DNA, RNA, histones, and non-histone proteins. Chromatin structure and function are critical for development and differentiation as well as for responding to external challenges. In particular, DNA methylation, specifically 5-methyldeoxycytosine (5mdC), is an epigenetic mark that has emerged as a powerful means by which both prokaryotes and eukaryotes regulate gene expression. It plays key roles in processes ranging from development to adaptation to genetic stability. Furthermore, this signal can be converted into a genetic alteration through spontaneous or enzymatic conversion of 5mdC into thymine. Thus, the crucial functions of 5mdC are balanced with the “costs” of this modification, with important implications for organismal evolution. We study the presence and the function of 5mdC in fission yeast, as well as the molecular actors involved in the process.

Fundings