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  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
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  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
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© Emmanuel Lemichez
Microscopy image showing the formation of large tunnels in a blood vessel endothelial cell induced by a group of bacterial toxins
Scientific Fields
Diseases
Organisms
Applications
Technique

Projects

Project
Ongoing
6 Members

Chronic carriage of CNF1-producing bacteria in the gut and development of colorectal cancer

Emmanuel Lemichez (PI)

CNF1 is a toxin that catalyzes the permanent activation of host RhoA, Rac1 and Cdc42 small GTPases by selective deamidation of a glutamine residue into a glutamic acid. This 1 dalton post-translational modification can […]
Project
Ongoing
7 Members

Endothelium disruption by toxin-induced transcellular tunnels

Emmanuel Lemichez (PI)

Crossing of the epithelium and endothelium barriers by pathogens and their toxins represents essential steps in pejorative evolution of infections. We have discovered that several exotoxins from S. aureus and C. botulinum disrupt epithelium and endothelium barriers by targeting […]
Project
Ongoing
11 Members

Detection and countermeasures against bacterial toxins

Emmanuel Lemichez (PI)

Bacterial protein toxins are molecular nanodevices endowed with the capacity of inducing host specific unparalleled pathophysiological effects. Therefore, major challenges in toxinology include the development of countermeasures other than vaccination against bacterial protein toxins […]
Project
Ongoing
8 Members

Inhibitors of bacterial NAD kinases

Sylvie Pochet (PI)

NAD mimics as potential antibacterial agents The NAD(P) biosynthesis pathways have attracted recent interest as a source of enzyme targets for the development of antimicrobial agents. Our own research focused on the structure-based development […]

Publications

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