Predicting single-cell fate during infection using machine learning
It has been suggested that certain metabolic conditions in macrophages could be key to permit intracellular infection. As intracellular bacteria are able to take up nutrients directly from the cytoplasm of infected cells and […]
Metabolic Host-Pathogen Interactions: Revealing how Intracellular Bacteria hijack Mitochondrial OXPHOS during Infection (ANR JCJC 2021)
Mitochondria are critical players in cellular metabolism. Mitochondrial respiration generates ATP by a process known as oxidative phosphorylation (OXPHOS), which involves the coordinated action of several complexes and accessory proteins in the electron transport […]
INNOV-10-19 – Mitochondrial Electron Transport Chain complexes: new targets to tackle infection by intracellular bacteria? (DARRI/Institut Carnot)
We previously showed that the intracellular bacterium Legionella pneumophila, the causative agent of Legionaries’ disease in humans, alters mitochondrial morphology by injecting the effector MitF in the host cell through its type IV secretion […]
2021Reverting the mode of action of the mitochondrial F O F 1-ATPase by Legionella pneumophila preserves its replication niche, Elife. 2021 Dec 9;10:e71978. doi: 10.7554/eLife.71978. Online ahead of print.
2020Danger-associated Metabolic Modifications During Bacterial Infection of Macrophages, Int. Immunol. 2020 May.