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© Carmen Buchrieser, Marie-Christine Prevost
Legionella pneumophila et son flagelle, bactérie responsable de pneumopathie aigue grave. Bactérie de l'environnement , l'émergence récente de cette maladie s'explique par son affinité pour les systèmes modernes d'alimentation en eau comme les tours de refroidissement. Image colorisée.
Project

INNOV-10-19 – Mitochondrial Electron Transport Chain complexes: new targets to tackle infection by intracellular bacteria? (DARRI/Institut Carnot)

Scientific Fields
Diseases
Organisms
Applications
Technique
Starting Date
01
Jun 2019
Ending Date
31
Dec 2020
Status
Completed
Members
3
Structures
3

About

We previously showed that the intracellular bacterium Legionella pneumophila, the causative agent of Legionaries’ disease in humans, alters mitochondrial morphology by injecting the effector MitF in the host cell through its type IV secretion system (T4SS), and therefore reduces mitochondrial respiration of infected human macrophages. As the ultrastructure of mitochondria is determinant for their respiratory activity, we hypothesized that alterations of the respiratory status of infected cells are caused by the reconfiguration of the mitochondrial Electron Transport Chain (ETC) complexes during infection. This project aimed to determine the putative role of ETC complexes during bacterial infection and explored the possibility of targeting them to tackle bacterial infection, as a host-directed therapy approach

Fundings